Flexible multifunctional corneal contact lens based on gamma-Fe2O3@NiO magnetic oxide nanosheets

A contact lens and magnetic oxide technology, applied in glasses/goggles, diagnostic recording/measurement, eye testing equipment, etc., to achieve outstanding reliability and stability, easy mass production, and low price

Active Publication Date: 2021-12-31
UNIV OF ELECTRONICS SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The contact lens innovatively uses γ-Fe 2 o 3 As a detection functional material, @NiO magnetic oxide nanosheets realize the simultaneous monitoring of three physiological signals of glucose, intraocular pressure and nystagmus, effectively solving the problems faced by the current multifunctional contact lenses, and the therapeutic device has excellent stability , low price, simple preparation process, and easy large-scale industrial production

Method used

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  • Flexible multifunctional corneal contact lens based on gamma-Fe2O3@NiO magnetic oxide nanosheets
  • Flexible multifunctional corneal contact lens based on gamma-Fe2O3@NiO magnetic oxide nanosheets
  • Flexible multifunctional corneal contact lens based on gamma-Fe2O3@NiO magnetic oxide nanosheets

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Embodiment 1

[0044] A γ-Fe based 2 o 3 A method for preparing a flexible multifunctional contact lens of @NiO magnetic oxide nanosheets, comprising the following steps:

[0045] Step 1. Synthesis of γ-Fe by one-step hydrothermal method 2 o 3 @NiO magnetic oxide nanosheets, the specific process is:

[0046] Add 0.1mol Fe(NO 3 ) 3 9H 2 O, 0.1mol Ni(NO 3 ) 3 9H 2 O and 1mm olCH 4 N 2 0, after being stirred evenly, transfer in the 50mL autoclave, put the foamed nickel (2*3cm) that has been pretreated into the above-mentioned autoclave simultaneously, react at a constant temperature at a temperature of 120°C for 6 hours, naturally cool to room temperature after the reaction finishes, Then take it out and rinse it several times with deionized water, and dry it overnight in a vacuum oven at 60°C to get γ-Fe on the surface of foamed nickel. 2 o 3 @NiO magnetic oxide nanosheets; the X-ray diffraction pattern of the nanosheets is as follows image 3 The scanning electron microscope ima...

Embodiment approach

[0062] Figure 8 It is a confocal microscope image of the multifunctional contact lens inner layer microfluidic channel encapsulation film provided by the embodiment of the present invention. It is only a specific implementation mode. All inner layer encapsulation films (1-8) with microfluidic channels can Realize tears passing through the inner packaging film (1-8) and reference electrode (1-4), counter electrode (1-6) and γ-Fe 2 o 3 The design of the @NiO magnetic oxide nanosheet sensing layer (1-5) contacts are all within the scope of protection. Such as Figure 8 As shown, where (8-1) is the tear inlet, (8-2) is the tear outlet, the microfluidic channel is mainly composed of a serpentine channel, a quasi-circular channel and an electrode layer setting area, and the line width is 300 μm. The serpentine design helps to collect tears, so that the tears completely wet the magnetic oxide nanosheet sensing layer, reference electrode and counter electrode. (8-3) is the refere...

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Abstract

The invention provides a flexible multifunctional corneal contact lens based on gamma-Fe2O3@NiO magnetic oxide nanosheets, and belongs to the technical field of biomedical instruments. The core structure of the contact lens is made of a gamma-Fe2O3@NiO magnetic oxide nanosheet material, and the material is combined with different parts of an electrochemical signal acquisition system, an external metal coil and a Teslameter, so that detection of three biological signals, namely, an eyeball tremor signal, an intraocular pressure signal and a glucose signal, is realized at the same time; namely detection of different physiological signals is achieved only through one sensor; meanwhile, the contact lens is high in sensitivity, relatively outstanding in reliability and stability, capable of carrying out real-time detection, simple in structure, low in price and easy to produce on a large scale.

Description

technical field [0001] The invention belongs to the technical field of biomedical devices, in particular to a γ-Fe-based 2 o 3 Flexible and multifunctional contact lenses with @NiO magnetic oxide nanosheets. Background technique [0002] A few days ago, the World Health Organization released the first "World Report on Vision", pointing out that population aging, lifestyle changes and limited access to eye care are the main factors for the increasing number of people with visual impairment worldwide. According to the report, at least 2.2 billion people around the world are visually impaired or blind, most of whom are mainly affected by irreversible chronic diseases such as diabetic retinopathy, glaucoma, and nystagmus. Some patients with these diseases have no obvious symptoms in the early stage, and it is difficult to detect them in time only by periodic routine physical examination. When clinical symptoms appear, many irreversible visual impairments have already occurred....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02C7/04A61B5/1473A61B5/145A61B3/16A61B3/113
CPCG02C7/049A61B3/16A61B3/113A61B5/14532A61B5/1473
Inventor 姚光谢茂雯张天垚王倩潘泰松高敏林媛
Owner UNIV OF ELECTRONICS SCI & TECH OF CHINA
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