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Noninvasive blood glucose rapid diagnosis differential Raman spectrum system

A Raman spectroscopy and differential technology, applied in the field of human blood component analysis and detection, can solve the problems of small oscillation and negative value, non-negative spectral value inconsistent, poor reduction effect, etc., to achieve simple operation, shorten detection time, Eliminate the effects of the physical examination process

Pending Publication Date: 2021-08-06
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] During the experiment, using the direct deconvolution algorithm for spectral restoration processing, there are indeed small oscillations and negative values, which are inconsistent with the non-negative nature of spectral values, and the restoration effect is not good

Method used

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  • Noninvasive blood glucose rapid diagnosis differential Raman spectrum system
  • Noninvasive blood glucose rapid diagnosis differential Raman spectrum system
  • Noninvasive blood glucose rapid diagnosis differential Raman spectrum system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Establish a glucose solution standard peak Raman spectrum library, as follows.

[0034] The wavelength of the excitation light source of the portable dual-wavelength Raman spectroscopy equipment is 784nm and 785nm. The wavelength fluctuation range is 1nm. Second.

[0035] Purchase glucose standard products (>99%), take human blood glucose concentration as a reference, and consider hypotension and hypertension at the same time, use a liquid gun to configure a glucose solution with a corresponding concentration gradient. Put the powder into a 50mL volumetric flask to obtain a mother liquor with a concentration of 20g / L (20mg / mL). Take 2ml from the mother liquor and dilute it into a 50mL volumetric flask to obtain a 80mg / dL glucose solution. ; Take 6mL mother liquor in the same way, and dilute it into a 50mL volumetric flask to obtain a 240mg / dL glucose solution. In the same way, the concentration of the solution is always adjusted to 30%. Pour solutions of different con...

Embodiment 2

[0037] Non-invasive blood sugar monitoring is performed on the middle part of the nail of the little finger of the human body, as follows

[0038] The experimental volunteers come from different body types, mainly to distinguish the difference in Raman spectrum signal intensity at different blood glucose concentrations. In order to make the volunteers more comfortable during the test, and to ensure that the signal is stable and real, a gradient pad is built on the side of the test bench. After putting the fingers on it, there are support points from the wrist to the arm (simulating the home autonomous test environment), and during the test process Among them, the volunteers are tested 10 times a day, and then the average value is taken as the data of the day, so as to exclude uncontrollable personal interference factors.

[0039] (1) Test on eight healthy volunteers with different blood sugar levels

[0040] Volunteers used a blood glucose meter to obtain the true value of bl...

Embodiment 3

[0045] Embodiment 3 verifies the accuracy specific method of this detection method as follows

[0046] Sort out the true values ​​of the blood glucose meters detected by the ten volunteers in Example 2, and conduct follow-up tests on them for 10 days intermittently (to avoid frequent blood glucose meter detection). Together they were imported into the Clarke Error Grid to assess the clinical utility of the blood glucose monitoring system. It is divided into five areas. Areas A and B represent valuable correct clinical decisions with Raman predictions and are acceptable in either direction, while areas C, D, and E are increasingly harmful erroneous decisions.

[0047] The results show that the predicted values ​​of the ten volunteers all exist in area A and area B, which meet the clinical medical detection standards.

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Abstract

The invention relates to a blood glucose meter for realizing noninvasive rapid detection of blood glucose based on a portable differential Raman spectrum technology. Firstly, Raman spectrum acquisition is conducted on the middle part of a little finger nail of a human body by utilizing two beams of light sources with different wavelengths to obtain two groups of blood glucose Raman data with tiny frequency shift; a fluorescence background is removed through a difference algorithm, a specific blood glucose signal is captured, direct multiple iteration deconvolution algorithm reduction is conducted on a Raman characteristic signal generated after difference, and an original Raman spectrum of the human body blood glucose is obtained; and finally, after Raman peak position matching of a standard glucose solution, an exact blood glucose concentration value can be output according to the corresponding relation between the spectral line intensity and the blood glucose concentration. According to the blood glucose meter, exciting light and collecting light share the same light path, on the basis that the size is effectively reduced, the convenience and usability of blood glucose monitoring are greatly improved, and any pretreatment is not needed. The blood glucose meter is convenient to operate, high in detection speed and high in accuracy, and has great guiding significance in prevention and treatment of diabetes mellitus.

Description

technical field [0001] The invention relates to a new type of instrument for quickly realizing the non-invasive detection of human blood sugar, which is based on a portable dual-wavelength excitation Raman spectrum system, and after processing by an algorithm, a strong original Raman spectrum signal is obtained for evaluating the health of the glucose concentration in the human body The indicator belongs to the field of analysis and detection of human blood components. Background technique [0002] In recent years, diabetes has become the third most common chronic disease in human beings. The incidence of this medically called "rich man's disease" is increasing year by year. According to statistics from the International Diabetes Federation, about 463 million adults worldwide suffer from diabetes. China Accounting for more than a quarter of 116.4 million, ranking first in the world. So far, there is no way to completely treat diabetes. In order to prevent hyperglycemia or h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/1455A61B5/145A61B5/00G06N3/04
CPCA61B5/1455A61B5/14532A61B5/72A61B5/7203A61B5/6826G06N3/045
Inventor 刘瑞斌李伟李安马威峰孔德男
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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