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Boron nanosheet composite material and preparation method thereof

A technology of composite materials and nanosheets, applied in the field of nanomaterials, can solve the problems of low antibacterial performance and achieve the effects of not easy to aggregate, broad-spectrum antibacterial spectrum, and high antibacterial rate

Active Publication Date: 2022-03-04
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the problems of agglomeration and low antibacterial properties in the preparation of boron nanosheets, the purpose of the present invention is to provide a method for preparing boron nanosheet composite materials, which uses surfactants to as

Method used

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  • Boron nanosheet composite material and preparation method thereof

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Embodiment 1

[0025] 1. Disperse 100mg of crystalline boron powder in 80mL of isopropanol, add 500mg of surfactant polyether P123, perform ultrasonic peeling of the probe at 500w power in a 5°C water bath for 3h, and centrifuge at 3000r / min for 10min. Remove the bulk unstripped crystalline boron powder, then centrifuge the supernatant at a speed of 12000r / min for 30min, collect the precipitate, alternately wash three times with absolute ethanol and deionized water, and freeze-dry for 24 hours to obtain dry boron nanometer piece.

[0026] 2. Take 2,3-epoxypropyltrimethylammonium chloride grafted natural chitosan 600mg with an average molecular weight of 10000 and dissolve it in 20mL deionized water to prepare a quaternary ammonium chitosan aqueous solution, add the prepared boron nanosheets, stirred at room temperature for 12h. The suspension was washed three times with deionized water to remove excess quaternized chitosan, and freeze-dried for 24 hours to prepare quaternized chitosan-modif...

Embodiment 2

[0030] 1. Disperse 80mg of amorphous boron powder in 80mL DMF, add the surfactant polyvinylpyrrolidone, perform ultrasonic peeling of the probe with 400w power in an ice-water bath for 3.5h, centrifuge at 3000r / min for 10min, and remove the block Then the supernatant was centrifuged at a speed of 12000r / min for 30min, the precipitate was collected, washed alternately with absolute ethanol and deionized water three times, and freeze-dried for 24 hours to obtain dry boron nanosheets.

[0031] 2. Dissolve 800 mg of natural chitosan with an average molecular weight of 12,000 modified by 3-chloro-2-hydroxypropyltrimethylammonium chloride in 20 mL of deionized water to prepare an aqueous solution of quaternary ammonium chitosan, and add the prepared Boron nanosheets, stirred at room temperature for 12h. The suspension was washed three times with deionized water to remove excess quaternized chitosan, and freeze-dried for 24 hours to prepare quaternized chitosan-modified boron nanoshe...

Embodiment 3

[0035] 1. Disperse 100mg of amorphous boron powder in 80mL of 2-butanol, add the surfactant sodium dodecylbenzenesulfonate, perform ultrasonic peeling of the probe at 400w power in an ice-water bath for 3.5h, and at 3000r / Centrifuge at a speed of 10 min for 10 min to remove the massive unstripped crystalline boron powder, then centrifuge the supernatant at a speed of 12000r / min for 30 min, collect the precipitate, wash three times alternately with absolute ethanol and deionized water, and freeze-dry for 24 hours Dry boron nanosheets were prepared.

[0036] 2. Take 2,3-epoxypropyltrimethylammonium chloride modified natural chitosan 800mg with an average molecular weight of 20000 and dissolve it in 20mL deionized water to prepare a quaternary ammonium chitosan aqueous solution, add the prepared boron nanosheets, stirred at room temperature for 12h. The suspension was washed three times with deionized water to remove excess quaternized chitosan, and freeze-dried for 24 hours to...

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Abstract

The invention belongs to the field of nano materials, and relates to a boron nanosheet composite material and a preparation method thereof, the boron nanosheet composite material with an antibacterial function is obtained by ultrasonically stripping boron nanosheets under the assistance of a surfactant, coating the surfaces of the boron nanosheets with quaternized macromolecules and embedding an organic nitric oxide donor with an antibacterial effect on the surfaces of the materials. The water dispersibility of the boron nano-material can be improved through a quaternization polymer modification method, so that the boron nano-material is not easy to aggregate and is suitable for different physiological environments; meanwhile, a nitric oxide donor is introduced into the surface of the nano material, photo-thermal therapy and controllable release of nitric oxide are synchronously achieved, healing and regeneration of growing cells are achieved, and the composite material has the advantages of being broad in antibacterial spectrum, high in antibacterial rate and not prone to generating drug resistance. The boron nanosheet composite material disclosed by the invention has an obvious inhibiting effect on the growth of escherichia coli, staphylococcus aureus and methicillin-resistant staphylococcus aureus, and can be applied to the fields of functional wound dressings infected by drug-resistant bacteria in clinical medicine and the like.

Description

technical field [0001] The invention belongs to the field of nanometer materials, and relates to a boron nanosheet composite material and a preparation method thereof. Background technique [0002] Diseases caused by the spread of pathogenic microorganisms have become one of the greatest threats to public health systems worldwide. With the advancement and development of science and technology, human beings are still troubled by pathogenic microorganisms. For example, although tuberculosis, known as the "white plague", has been controlled to a certain extent with the development of medical technology, a large number of anti-tuberculosis drugs have little effect on drug-resistant patients, and there are about 10 million new tuberculosis cases worldwide every year; 2020 Since the beginning of the year, the novel coronavirus has swept the world. As of now, the cumulative number of confirmed cases worldwide has exceeded 255 million; it is urgent to effectively control the spread...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/61A61P17/02A61P31/04B82Y5/00B82Y30/00B82Y40/00A61K33/00
CPCA61K47/61A61K33/00A61K41/0052A61P31/04A61P17/02B82Y5/00B82Y30/00B82Y40/00A61K2300/00Y02A50/30
Inventor 叶俊伟吕佳林宁桂玲
Owner DALIAN UNIV OF TECH