System for prognosis evaluation of pancreatic solid pseudopapilloma

Abstract

The invention relates to a system for predicting prognosis based on pathological morphology characteristics and proliferation indexes of pancreatic solid pseudopapilloma. The invention relates to an operation excision specimen for pancreatic solid pseudopapilloma, which comprises the following steps of: firstly, preparing a hematoxylin-eosin staining (HE) slice by fully taking materials, judging whether lymphatic vessel invasion (LVI) exists or not by using a light microscope, and then evaluating a tumor proliferation index (Ki-67,%) by using an immunohistochemical staining (IHC) method. According to an evaluation system, if LVI exists and Ki-67 is greater than or equal to 3%, a disease progression high-risk group is determined; lVI and Ki-67 lt exist in the sample; if LVI does not exist and Ki-67 is greater than or equal to 3%, the group is a medium-risk group; lVI and Ki-67 lt do not exist; and 3% of the group is a low-risk group. The system can accurately predict the progression condition of pancreatic solid pseudopapilloma, and is more effective than the eighth version of pancreatic cancer staging of the American United Cancer (AJCC) which is internationally applied at present. In addition, the invention also proposes that the pancreatic solid pseudopapilloma is excellent in prognosis and should be determined as a benign or junctional tumor according to the risk degree of the pancreatic solid pseudopapilloma.

Description

technical field [0001] The invention relates to the technical field of tumor prognosis, in particular to a prognosis evaluation system for solid pseudopapillary tumor of the pancreas. Background technique [0002] Solid pseudopapillary tumor of the pancreas is a relatively rare exocrine pancreatic tumor. With the deepening of its understanding, the number of definite diagnosis cases reported in the literature is on the rise, but its biological behavior is still unclear. Since the first report by Frantz in 1959, the characterization of the disease has undergone a series of changes: the 2000 edition of "WHO Pathology and Genetics of Digestive System Tumors" classified it as solid pseudopapillary tumor of uncertain malignant potential (ICD-O code 8452 / 1) and malignant solid pseudopapillary carcinoma (ICD-O code 8452 / 3), but the diagnostic criteria for malignancy have not been clearly established, only perineural invasion, vascular invasion, or deep invasion into surrounding tis...

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Problems solved by technology

[0008] In recent years, some studies have focused on the prognostic factors of solid pseudopapillary tumors. However, limited by the small number of total cases and recurrent / metastatic cases, short follow-up time, and unclear definition of malignant indicators, etc. The results of various studies are quite different, and the indicators proposed are not the same, so it is difficult to extract factors that are clearly related to prognosis

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