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Application of deubiquitinating enzyme USP45 in preparation of medicine for treating esophageal cancer

A technology for deubiquitinating enzymes and esophageal cancer, applied in the field of biomedicine, can solve the problems of no research revealing the mechanism of action of USP45

Active Publication Date: 2022-06-28
NANYANG INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no research to reveal the mechanism of action of USP45 in tumorigenesis and development

Method used

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  • Application of deubiquitinating enzyme USP45 in preparation of medicine for treating esophageal cancer
  • Application of deubiquitinating enzyme USP45 in preparation of medicine for treating esophageal cancer
  • Application of deubiquitinating enzyme USP45 in preparation of medicine for treating esophageal cancer

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Embodiment Construction

[0021] The features and advantages of the present invention can be further understood from the following detailed description in conjunction with the accompanying drawings. The description is an explanation of the content of the invention and does not in any way limit the rest of the disclosure of the invention.

[0022] The basis for supporting the content protected by the present invention is given below.

[0023] 1. Experimental methods and experimental operations

[0024] 1. Bioinformatics analysis

[0025] Normalized RNA-Seq data for esophageal cancer were downloaded from the TCGA database via UCSC Xena (https: / / xena.ucsc.edu / ). RNA-Seq data of human normal tissues were downloaded from the GTEx database (https: / / commonfund.nih.gov / GTEx). We further extracted the expression data of ENSG00000123552 (USP45) gene in each sample according to the filtering principle of normal solid tissue, primary solid tumor, primary tumor and normal tissue. Then, log2(x+1) transformation ...

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Abstract

The invention discloses application of deubiquitinating enzyme USP45 in preparation of a medicine for treating esophageal cancer, and belongs to the technical field of biological medicine. The invention finds that the mRNA expression level of the USP45 in esophageal cancer tissues is up-regulated and is related to the total lifetime of esophageal cancer patients, and the protein expression level of the USP45 in the esophageal cancer tissues is increased; uSP45 knock-down can significantly inhibit proliferation of esophageal cancer cells. The invention provides application of USP45 serving as an esophageal cancer molecular diagnosis marker or a prognosis prediction marker and application of USP45 serving as a target spot in preparation of drugs for treating esophageal cancer.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of deubiquitinase USP45 as an esophageal cancer cell proliferation regulating molecule and USP45 as a target in preparing a drug for treating esophageal cancer. Background technique [0002] According to the global epidemiological survey of tumors, esophageal cancer is one of the most common tumors in the world. In China, despite the continuous progress in the diagnosis and treatment of esophageal cancer, the prognosis of patients with esophageal cancer is still poor, and the 5-year survival rate has increased from 10% to 10%. to 25%. Therefore, it is an urgent research topic to deeply explore the pathogenesis of esophageal cancer and find potential therapeutic targets for esophageal cancer. [0003] USP45 is a member of the USPs (ubiquitin-specific proteases) family of deubiquitinating enzymes. Ubiquitination controls the stability of most intracellular pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K48/00A61P35/00C12Q1/6886G01N33/573G01N33/574
CPCA61K45/00A61K48/005A61P35/00C12Q1/6886G01N33/573G01N33/57407G01N33/57484C12Q2600/118C12Q2600/158G01N2333/948G01N2800/7028G01N2800/52
Inventor 李凯王倩卞华段培培杜瑞娟
Owner NANYANG INST OF TECH
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