Chewable solid unit dosage forms and methods for delivery of active agents into occlusal surfaces of teeth

Abstract

The present invention relates to methods and an oral care composition for topical, oral administration in a human or other animal comprising: a. from about 1% to about 40%, by weight of the composition, of a retentive agent selected from the group consisting of water soluble hydrophilic gums, water soluble hydrophilic polymers, and mixtures thereof, the retentive agent having the property of hydrating upon exposure to water or saliva resulting in the composition forming an intact hydrated mass to provide a Retention Index of about 1 to about 4; and b. a safe and effective amount of a topical,oral care carrier; wherein the composition is a non-cariogenic, chewable solid unit dosage form; and the composition comprises less than about 65% by weight of water insoluble particulates.The present invention further relates to an oral care dentifrice composition comprising: a. from about 30% to about 65%, by weight of the composition, of a water insoluble, particulate retentive agent having a water solubility of less than about 1g / 30g at 25 DEG C; b. a safe and effective amount of an oral care active; c.a safe and effective amount of a surfactant; d. a safe and effective amount of a buffer; wherein the composition is a chewable dentifrice solid unit dosage form, is non-effervescent, non-cariogenic; and wherein the composition has a Retention Index of from about 1 to about 4.

Description

Chewable solid unit dosage forms and methods useful for delivering active agents to occlusal surfaces of teeth technical field The present invention relates to chewable solid unit dosage form compositions and methods of delivering, especially sustained delivery of, fluoride or other oral care actives into the oral cavity. Utilizing the mechanical force of an individual's biting or chewing, minimal amounts of the compositions of the present invention can be deposited and retained in the tooth surfaces, especially the dimples, fissures and occlusal surfaces of the teeth. The compositions of the present invention comprise retention agents and optionally one or more agents such as oral care actives, abrasives, foaming agents, flavors / sensates, and / or specific buffer systems. The present invention also relates to chewable solid compositions and methods of providing a pH buffering agent on or at tooth surfaces and in the oral cavity. These compositions include chewable dentifrice ...

AI Technical Summary

Problems solved by technology

Also, the prior art does not address adequate methods for providing pH buffering agents on or at the tooth surface, especially the pits, fissures and occlusal surfaces of teeth where most caries forms

Images