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Combination of desoxypeganine and mecamylamine for the treatment of alcohol abuse

An active substance, alcohol abuse technology, applied in the field of pharmaceutical preparations, can solve the problem of no mention of active substance combination, no biological data, etc.

Inactive Publication Date: 2006-05-10
HF ARZNEIMITTELFORSCHUNG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these documents do not present biological data regarding this option, nor do they mention any combination with other pharmacologically active substances for this therapeutic purpose

Method used

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  • Combination of desoxypeganine and mecamylamine for the treatment of alcohol abuse
  • Combination of desoxypeganine and mecamylamine for the treatment of alcohol abuse
  • Combination of desoxypeganine and mecamylamine for the treatment of alcohol abuse

Examples

Experimental program
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Effect test

Embodiment 1

[0021]Alcohol consumption and alcohol preference in rats with reduced alcohol preference

[0022] Rats of the "AA" strain from Finland have a genetically determined preference for alcohol, which means that even without pretreatment with alcohol, when given a free choice, these animals prefer liquids containing alcohol over non-alcoholic liquids. Alcoholic liquid for its fluid needs. Therefore, this strain has been used in numerous alcohol pharmacology studies and its characteristics are well understood.

[0023] Female AA rats (for alcohol abuse testing, obtained from the Institute of Public Health, Helsinki) were housed individually and had free access to standard chow (Altromin 1324 pellets) at an ambient temperature of 24 + / - At 1°C, the change of light and shade is 12 / 12 hours (the dark period lasts from 6 pm to 6 am). Each cage contained two identical water bottles, one containing pure water and the other containing ethanol water (10% v / v). During the 12 hour dark peri...

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PUM

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Abstract

An active substance composition comprising deoxypeganine (deoxypeganine) or one of its pharmaceutically acceptable derivatives, and mecamylamine (mecamylamine) or one of its pharmaceutically acceptable derivatives, used to produce Medicaments for the treatment of alcohol abuse and / or alcohol dependence.

Description

technical field [0001] The present invention relates to a pharmaceutical preparation containing 3-deoxypeganine and / or mecamylamine. The invention further relates to the use of this active substance composition for the treatment of unhealthy alcohol consumption and alcohol dependence. Background technique [0002] Of the many psychoactive substances with potential for abuse, ethanol (known in common usage as "alcohol") is the oldest, most widely used and clearly the most valuable in terms of health effects and its social and economic effects. Attention. It is generally believed that about 1.6 million people in Germany are clinically dependent on alcohol and 2.7 million consume alcohol to a medically harmful level. About five million people need to be considered at risk. About 40,000 people - not only those who are clinically dependent on alcohol, but also those who consume alcohol regularly and at high risk over a long period of time - die each year as a direct consequenc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/13A61K31/53A61K45/06A61P25/32
CPCA61K31/13A61K31/53A61K45/06A61P25/32A61P43/00A61K2300/00
Inventor 希尔克·温特霍夫若阿欣·莫尔曼克劳斯·奥皮茨
Owner HF ARZNEIMITTELFORSCHUNG
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