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Pharmaceutical effect of berbamine derivative EBB in inhibiting invasive metastasis of human body tumor cell

A technology of tumor cells and berbamine, which is applied in the direction of antineoplastic drugs and drug combinations, and can solve problems that have not been reported

Inactive Publication Date: 2006-08-02
INST OF HEMATOLOGY & BLOOD HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no report on the inhibitory effect of calmodulin antagonist berbamine derivative EBB on tumor cell invasion and metastasis

Method used

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  • Pharmaceutical effect of berbamine derivative EBB in inhibiting invasive metastasis of human body tumor cell
  • Pharmaceutical effect of berbamine derivative EBB in inhibiting invasive metastasis of human body tumor cell
  • Pharmaceutical effect of berbamine derivative EBB in inhibiting invasive metastasis of human body tumor cell

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Embodiment Construction

[0072] Berbamine derivative EBB is a compound soluble in dilute hydrochloric acid, and can be made into corresponding water or powder according to conventional methods. It can also be made into capsules and tablets with physiologically acceptable carriers and excipients. It can also be mixed with other supplementary drugs to make capsules and tablets. The clinical dose of berbamine derivative EBB is 10-120 mg / d, preferably 10-80 mg / d.

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Abstract

The present invention relates to the pharmaceutical application of berbamine derivative EBB in inhibiting invasive metastasis of human body tumor cell. The medicines can inhibit the metastasis of tumor cell through protecting basement membrane against destruction, and has obvious effects of lowering the expression of MMP-2 and MMP-9, strengthening the expression of TIMP and thus raising TIMP / MMP ratio. The berbamine derivative EBB is compound soluble in dilute hydrochloric acid solution, and may be prepared into corresponding water solution or powder in conventional process, into capsule or tablet via adding pharmaceutically acceptable carrier and supplementary material, or into capsule or tablet via adding supplementary medicine. The clinic dosage of berbamine derivative EBB is 10-120 mg / day, preferably 10í½80 mg / day.

Description

technical field [0001] The invention relates to the drug application of berbamine derivative EBB in inhibiting the invasion and metastasis of human tumor cells. This kind of substance inhibits the metastasis of tumor cells by protecting the basement membrane from damage. Background technique [0002] Tumor metastasis is the main cause of anticancer treatment failure and patient death. According to clinical statistics, more than 80% of cancer patients died of tumor invasion and metastasis, so research in this area has been receiving special attention. Tumor invasion and metastasis is an active process. Litta once summarized this process into three steps: (1) Tumor cells adhere to extracellular matrix components; (2) Tumor cells release or induce the release of proteolytic enzymes to degrade extracellular matrix. (3) Tumor cells in the degraded area migrate under the guidance of chemokines. A perfect extracellular matrix and basement membrane can limit the invasion and metas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4738A61P35/00
Inventor 朱惠芳刘杰文齐淑玲潘兵周圆齐静杨纯正熊冬生姜文国程燕红赵轼轩扬铭张永慈邹凌琳刘娟妮
Owner INST OF HEMATOLOGY & BLOOD HOSPITAL CHINESE ACAD OF MEDICAL SCI
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