Methods and compositions for evaluating breast cancer prognosis

a breast cancer and prognosis technology, applied in the field of breast cancer prognosis evaluation methods and compositions, can solve the problems of poor ten-year outcome of approximately 20% of women diagnosed with early-stage breast cancer, recommendation of aggressive adjuvant therapy, and no widely used assay to risk stratify patients for more aggressive treatment. , to achieve the effect of accurate evaluation of breast cancer prognosis and good prognosis
US20060063190A1Inactive Publication Date: 2006-03-23TRIPATH IMAGING INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
TRIPATH IMAGING INC
Publication Date
2006-03-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods and compositions for evaluating the prognosis of a breast cancer patient, particularly an early-stage breast cancer patient, are provided. The methods of the invention comprise detecting expression of at least one, more particularly at least two, biomarker(s) in a body sample, wherein overexpression of the biomarker or a combination of biomarkers is indicative of breast cancer prognosis. In some embodiments, the body sample is a breast tissue sample, particularly a primary breast tumor sample. The biomarkers of the invention are proteins and / or genes whose overexpression is indicative of either a good or bad cancer prognosis. Biomarkers of interest include proteins and genes involved in cell cycle regulation, DNA replication, transcription, signal transduction, cell proliferation, invasion, proteolysis, or metastasis. In some aspects of the invention, overexpression of a biomarker of interest is detected at the protein level using biomarker-specific antibodies or at the nucleic acid level using nucleic acid hybridization techniques.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Provisional Application Ser. No. 60 / 612,073, filed Sep. 22, 2004, and U.S. Provisional Application Ser. No. 60 / 611,965, filed Sep. 22, 2004, both of which are incorporated herein by reference in their entirety.FIELD OF THE INVENTION

[0002] The present invention relates to methods and compositions for evaluating the prognosis of a patient afflicted with breast cancer, particularly early-stage breast cancer. BACKGROUND OF THE INVENTION

[0003] Breast cancer is the second most common cancer among American women, less frequent only than skin cancer. An American woman has a one in eight chance of developing breast cancer during her lifetime, and the American Cancer Society estimates that more than 250,000 new cases of breast cancer will be reported in the U.S. this year. Breast cancer is the second leading cause of cancer deaths in women, with more than 40,000 Americans expected to die from the dise...

Claims

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