Glucose biological sensor capable of eliminating interference

A biosensor and interference elimination technology, which is applied in biological testing, instruments, scientific instruments, etc., can solve problems such as interference in measurement, and achieve the effects of eliminating interference, safe use, and stable performance

Inactive Publication Date: 2006-08-09
YANGZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since there are often multiple coexisting substances in the sample, these coexisting substances often interfere with the determination

Method used

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  • Glucose biological sensor capable of eliminating interference
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Embodiment Construction

[0012] like figure 1 As shown, in the glucose oxidase biosensor of the four-electrode system designed in the present invention, the same potential is applied to the two working electrodes by a precision bipotentiostat. The difference between the currents of the two working electrodes is determined by a current subtractor. Since the polypyrrole membranes of the two electrodes are prepared under exactly the same conditions, when only interfering substances exist in the solution, the interfering substances will generate exactly the same interfering currents on the two working electrodes. Therefore, the measured current difference to zero. When the substrate and interfering substances coexist in the solution, the current measured by the enzyme-containing electrode is the sum of the response current of the substrate enzyme-catalyzed reaction and the response current of the interfering substance, while the current measured by the electrode without enzyme is only the interfering sub...

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Abstract

Present invention discloses interference elimination glucose biosensor referring to new glucose sensor measuring method. It contains double constant potential rectifier, electrolytic bath, and electric current subtracter, wherein said electrolytic bath composed of four electrode system, which arepolypyrrole membrane-glucose oxidase electrode as working electrode W 1, polypyrrole membrane electrode as working electrode W 2, platinum sheet electrode as auxiliary electrode , saturated calomel electrode as reference electrode R. Present invention utilizes polypyrrole-polypyrrole glucose oxidase double working electrode system effectively eliminating variety inorganic substance organic matter coexist body interference to measuring.

Description

technical field [0001] The invention relates to a new method for eliminating the interference of glucose sensor measurement-polypyrrole-polypyrrole glucose oxidase double working electrode method. Background technique [0002] British scholars Clark and Lyons proposed in 1962 that the high specificity of the enzymatic reaction and the high sensitivity of the electrode response could be combined, thus proposing the concept of the enzyme electrode. Since 1967, Updile and Hicks successfully developed a glucose enzyme sensor, until the 1970s, new biosensors were continuously developed, and there have been a large number of literature reports on immobilized enzymes. Enzyme biosensors are of great help to medical diagnosis and environmental analysis, such as glucose oxidase and uricase sensors. Glucose is one of the important products of human metabolism. Many diseases are related to the content of glucose in blood. Determining the concentration of glucose in human serum has impo...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): G01N27/403G01N33/48
Inventor阚锦晴姜燕
OwnerYANGZHOU UNIV