Preparation of dampness eliminating wind dispelling and preparation method

A technology of preparations and traditional Chinese medicine preparations, applied in anti-inflammatory agents, pill delivery, pharmaceutical formulations, etc., can solve problems such as large doses, many impurities, and impacts on clinical applications

Inactive Publication Date: 2006-08-30
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But in practice, because the medicine is prepared by powdering the medicinal materials into the medicine, there are many impurities and large doses, which seriously affect its clinical application.

Method used

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  • Preparation of dampness eliminating wind dispelling and preparation method
  • Preparation of dampness eliminating wind dispelling and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] The preparation method of dropping pill of the present invention:

[0085] prescription:

[0086] Fungus 510g Atractylodes (stir-fried with bran) 85g Raw Aconitum 17g

[0087] Raw Grass Aconitum 17g Eucommia (stir-fried with salt) 17g Achyranthes bidentata 17g

[0088] Cimicifuga 17g Liushenqu (stir-fried bran) 17g

[0089] PEG4000 100g

[0090] Makes 1000 pills

[0091] Preparation:

[0092] (1) Take herb herb and use supercritical extraction method (or steam distillation method): put it into a supercritical extraction tank, and extract it for 3.0-4.0 hours under the conditions of pressure 20MPa, temperature 40°C, and flow rate 20L / h ; With a pressure of 5.5MPa, a temperature of 34.5°C (separation I), and 34.8°C (separation ∏) for analysis to obtain the extract; β-CD inclusion, the best process is: the ratio of β-CD to water is 1:8 , the ratio of oil to β-CD is 1:6, ultrasonication for 40min, and clathrate is obtained;

[0093] (2) Take Liushenqu, soak in water ...

Embodiment 2

[0097] The preparation method of soft capsule of the present invention:

[0098] prescription:

[0099] Fungus 1800g Atractylodes (stir-fried with bran) 300g Raw Aconitum 60g

[0100] Raw Grass Aconitum 60g Eucommia (stir-fried with salt) 60g Achyranthes bidentata 60g

[0101] Cimicifuga 60g Liushenqu (stir-fried bran) 60g

[0102] PEG400 350g

[0103] Makes 1000 capsules

[0104] Preparation:

[0105] (1) Take herb herb and use supercritical extraction method (or steam distillation method): put it into a supercritical extraction tank, and extract it for 3.0-4.0 hours under the conditions of pressure 20MPa, temperature 40°C, and flow rate 20L / h ; With a pressure of 5.5MPa, a temperature of 34.5°C (separation I), and 34.8°C (separation ∏) for analysis to obtain the extract; β-CD inclusion, the best process is: the ratio of β-CD to water is 1:8 , the ratio of oil to β-CD is 1:6, ultrasonication for 40min, and clathrate is obtained;

[0106] (2) Take Liushenqu, soak it in ...

Embodiment 3

[0110] The preparation method of granule of the present invention:

[0111] prescription:

[0112] Fungus 2100g Atractylodes (stir-fried with bran) 350g Raw Aconitum 70g

[0113] Raw Grass Aconitum 70g Eucommia (stir-fried with salt) 70g Achyranthes bidentata 70g

[0114] Cimicifuga 70g Liushenqu (stir-fried bran) 70g

[0115] Made into 1000g

[0116] Preparation:

[0117] (1) Take Liushenqu and Atractylodes atractylodis as medicine;

[0118] (2) Take the remaining medicinal materials, soak them with 85% ethanol for 30 minutes, then heat and reflux for extraction 3 times, each time for 1 hour, combine the extracts, concentrate under reduced pressure to form a thick paste, and set aside;

[0119] (3) Combine the above active ingredients, add 5.0 g of aspartame and 210.0 g of dextrin, granulate, dry, and spray 5.0 g of essence to obtain 1000 g of granules.

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Abstract

A Chinese medicine in the form of dripping pill or soft capsule for treating cold-damp rheumatism, lumbocrural pain, rickets, etc is disclosed. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine composition and a preparation process thereof, in particular to a prescription for cold-damp arthralgia, pain in the waist and legs, contracture, flaccidity, difficulty walking, and numb hands and feet and a preparation process thereof. Background technique: [0002] Cold-damp arthralgia, waist and leg pain, contracture, flaccidity, difficulty walking, and numb hands and feet are common clinical symptoms. Traditional Chinese medicine often adopts dehumidification and wind dispelling, warming the meridian and dispelling cold, and relieving pain and relieving numbness to treat it. significantly. Erxian Pill is its representative medicine. However, in practice, because the medicine is prepared by powdering the medicinal materials, it leads to many impurities and large doses, which seriously affects its clinical application. [0003] Compared with ordinary pills, the preparation prepared by the ext...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/71A61K9/00A61K9/06A61K9/16A61K9/20A61K9/48A61P29/00
Inventor刘露
OwnerFUKANGREN BIO PHARMA