Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof

a technology of histone deacetylase and cytodifferentiating agent, which is applied in the field of new cytodifferentiating agent and histone deacetylase inhibitors, can solve the problems of limited potency of hmba, and achieve the effect of inhibiting proliferation
US20070010536A1Inactive Publication Date: 2007-01-11SLOAN KETTERING INST FOR CANCER RES +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
SLOAN KETTERING INST FOR CANCER RES
Publication Date
2007-01-11
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkyloxy, or pyridine group; wherein A is an amido moiety, —O—, —S—, —NH—, or —CH2—; and wherein n is an integer from 3 to 8. The present invention also provides a method of selectively inducing growth arrest, terminal differentiation and / or apoptosis of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.
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Description

RELATED APPLICATIONS

[0001] This application is a continuation of U.S. application Ser. No. 09 / 645,430, filed Aug. 24, 2000 which claims the benefit of U.S. Provisional Application 60 / 208,688 filed Jun. 1, 2000 and U.S. Provisional Application 60 / 152,755; filed Sep. 8, 1999.

[0002] Throughout this application various publications are referenced by Arabic numerals within parentheses. Full citation for these publications may be found at the end of the specification immediately preceding the claims. The disclosures of these publications in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art to which this invention pertains.BACKGROUND OF THE INVENTION

[0003] Cancer is a disorder in which a population of cells has become, in varying degrees, unresponsive to the control mechanisms which normally govern proliferation and differentiation. A recent approach to cancer therapy has been to attempt induction of terminal...

Claims

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