Growth Factor Analogs

a technology of growth factor and analogs, which is applied in the direction of peptides/protein ingredients, peptides, immunoglobulins, etc., can solve the problems of high preparation cost, general difficulty in preparation, and none of these or other known heparin-binding growth factor analogs provide the advantages, so as to stimulate the signaling of growth factor receptors and stimulate cell proliferation.
US20090143566A1Inactive Publication Date: 2009-06-04BIOSURFACE ENG TECH
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
BIOSURFACE ENG TECH
Publication Date
2009-06-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides synthetic heparin-binding growth factor analogs of formulas I or II as given in the specification, having two peptide chains branched from a dipeptide branch moiety composed of at least one and preferably two trifunctional amino acid residues, which peptide chain or chains bind a heparin-binding growth factor receptor. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.
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Description

CROSS-REFERENCE TO RELATED APPLICATION

[0001] This application is a divisional application of U.S. patent application Ser. No. 11 / 051,292, entitled “Growth Factor Analogs,” filed on Feb. 4, 2005. This application also claims the benefit of the filing of U.S. Provisional Patent Application Ser. No. 60 / 542,272, entitled “Growth Factor Analogs”, filed on Feb. 4, 2004, and the specification thereof is incorporated herein by reference.BACKGROUND OF THE INVENTION

[0002] 1. Field of the Invention (Technical Field)

[0003] The invention relates to the field of synthetic peptides and analogs of heparin-binding growth factors. The invention further relates to the clinical uses of such analogs as soluble drugs and as coatings for medical devices.

[0004] 2. Description of Related Art

[0005] Note that the following discussion refers to a number of publications by author(s) and year of publication, and that due to recent publication dates certain publications are not to be considered as prior art vis-a-vis ...

Claims

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