Use of one or more metal carriers to selectively kill mammalian cells

a technology of metal carriers and mammalian cells, which is applied in the direction of transferrins, peptides, powder delivery, etc., can solve the problems of inducing rapid death of mammalian cells, and achieve the effect of enhancing the accuracy of toxic metal delivery and high affinity
US20100137557A1Inactive Publication Date: 2010-06-03ZOLTAN LAB
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
ZOLTAN LAB
Publication Date
2010-06-03
Estimated Expiration
Not applicable · inactive patent

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Abstract

Compositions and methods for decreasing the viability of cells, particularly aberrant non-healthy cells, and most particularly cancer cells, are disclosed. The primary agent that causes cell death is a toxic metal atom or ion. Embodiments of the invention provide compositions and methods to ensure that the toxic metal is directed to the desired cell or tissue. In one embodiment, the metal is bound to a sulfur-rich peptide or protein carrier containing a targeting moiety. Such metal-protein complex is targeted to the selected cells or tissues to enrich the cell or tissue site with the metal-containing peptide or protein molecules followed by administering a dithiocarbonyl which carries the metal from the protein inside the cells to induce cell death.
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Description

PRIORITY CLAIM

[0001] This application is a continuation of U.S. application Ser. No. 11 / 472,763, filed Jun. 22, 2006, entitled “Use of one or More Metal Carriers to Selectively Kill Mammalian Cells” which claims the benefit of U.S. Provisional Application No. 60 / 697,181, filed Jul. 7, 2005, entitled “Use of one or More Metal Carriers to Selectively Kill Mammalian Cells” both of which are incorporated by reference in their entirety.FIELD OF THE INVENTION

[0002] This invention relates to compositions designed to selectively decrease the viability of targeted diseased cells, such as cancer cells, by facilitating transport of potentially toxic metals such as zinc, cadmium, copper or others, across the cell membrane.BACKGROUND

[0003] There are many pathological conditions, particularly cancer, when aberrant tissue growth poses serious health hazard that would require rapid, selective, and effective elimination of the constituent aberrant cells. There are three major procedures in the medic...

Claims

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