Treatment of acute exacerbations of chronic obstructive pulmonary disease by antagonism of the il-20r
an antagonism and chronic obstructive pulmonary disease technology, applied in the direction of antibacterial agents, drug compositions, antibody medical ingredients, etc., can solve the problems of affecting the health and quality of life of subjects, severe and increasing global health problems, and prior exacerbation is an independent risk factor
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[0060]Introduction:
[0061]Bacterial complications are a common feature during a wide variety of lung inflammatory disorders such as COPD. In patients with COPD, acute exacerbation is mostly associated with bacterial infections frequently due to Haemophilus influenzae and Streptococcus pneumoniae. These infections provoked a strong inflammatory reaction characterized by neutrophil recruitment, increased production of pro-inflammatory cytokines and accelerated the progression of the disease. Appropriate models are needed to better define mechanisms responsible for bacterial susceptibility during the exacerbation of COPD. We have already developed a murine model of COPD by chronic exposure to cigarette smoke (CS) during 12 weeks. This exposure strongly modifies the innate immune response in the lung and the activation of invariant natural killer T (iNKT) cells (Pichavant M et al., Mucosal Immunol, 2014). To better define the mechanisms responsible for bacterial susceptibility, we have n...
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