Anticancer Chinese medicinal composition and preparation method thereof

Abstract

The invention provides a Chinese medicinal composition against tumor comprising active constituents such as pinellia tuber and arisaema tuber, as well as various oral administration dose forms and process for preparation. Animal experiment shows that, the composition has appreciable inhibitory action to the in-vivo growth and transfer of S180 solid tumor, ascite tumor and MKN-45 human gastric cancer. In Vitro experiment shows that, the composition has killing action to human gastric cancer MKN-45 and human lung carcinoma SPCA-1 cells.

Description

Technical field:

[0001] The invention relates to the technical field of medicine, in particular to an anti-tumor traditional Chinese medicine composition and a preparation method thereof. Background technique:

[0002] Gastric cancer is one of the malignant tumors with high recurrence and metastasis, and the five-year survival rate is still low. Postoperative treatment of gastric cancer currently includes chemotherapy, immunotherapy, biological therapy, etc. A variety of anti-tumor chemotherapy drugs have been used in the treatment of gastric cancer, but the curative effect on recurrence and metastasis is not satisfactory, and the side effects are relatively large. Traditional Chinese medicine therapy has its own advantages in the treatment of tumors, prolongs the survival time, improves the quality of life, and has the characteristics of safety and low toxicity. Conversely, theories and methods are different, so a variety of anti-tumor traditional Chinese medicine preparat...

Examples

Embodiment 1

[0023] Take the following proportioning medicinal materials:

[0024] Pinellia 150g Nanxing 150g Shan Cigu 300g Scorpion 30g

[0025] Centipede 150g Tianlong 150g Toad Shell 90g Aesculus Aesculus 300g

[0026] 300g snakeberry fried chicken gold 60g agarwood 60g roasted licorice 60g

[0027] Scorpion, centipede, Tianlong, toad shells are crushed into coarse powder according to the ratio, add 1500ml of water and soak for 24 hours, according to the percolation method under flow extract and extract, use 70% ethanol to percolate, collect the filtrate, Ethanol was recovered from the filtrate, allowed to stand, and filtered for later use. Add 1000ml of water to the medicinal dregs, decoct twice for 1 hour each time, combine the decoction, filter, combine the filtrate with the above aqueous solution, concentrate under reduced pressure at 0.8kpa to 500ml for later use.

[0028] Add 2000ml of water to Nanxing, Pinellia, and Arrowhead, soak for 24 hours, add water and boil for 2 hours...

Embodiment 2

[0031] Take the following proportioning medicinal materials:

[0032] Pinellia 90g Nanxing 90g Scorpion 30g

[0033] Centipede 90g Tianlong 90g Toad Shell 90g Aescin 150g

[0034] 150g snakeberry fried chicken gold 60g agarwood 30g roasted licorice 30g

[0035] Scorpion, centipede, Tianlong, toad shells are crushed into coarse powder according to the ratio, and after adding 1000ml of water to soak for 48 hours, according to the percolation method under flow extract and extract, percolate with 50% ethanol, collect the percolation, Ethanol was recovered from the filtrate, allowed to stand, and filtered for later use. Add 1000ml of water to the dregs, decoct 3 times, 1 hour each time, combine the decoction, filter, combine the filtrate with the above aqueous solution, concentrate under reduced pressure at 0.8kpa to 500ml for later use.

[0036] Add 1000ml of water to Nanxing and Pinellia, soak for 48 hours, add water to decoct for 2 hours, collect the decoction, filter and set...

Embodiment 3

[0039] Take the following proportioning medicinal materials:

[0040]Pinellia 150g Nanxing 150g Shan Cigu 150g Scorpion 60g

[0041] Centipede 150g Tianlong 150g Toad Shell 90g Aesculus Aesculus 300g

[0042] 150g snakeberry fried chicken gold 30g agarwood 60g roasted licorice 30g

[0043] Scorpion, centipede, dragon, and toad shells are crushed into coarse powder according to the proportion, and after adding 1500ml of water to soak for 48 hours, according to the percolation method under the flow extract and extract, use 80% ethanol to percolate, collect the percolation, Ethanol was recovered from the filtrate, allowed to stand, and filtered for later use. Add 1000ml of water to the dregs, decoct 3 times, 1 hour each time, combine the decoction, filter, combine the filtrate with the above aqueous solution, concentrate under reduced pressure at 0.8kpa to 500ml for later use.

[0044] Add 2000ml of water to Nanxing, Pinellia, and Arrowhead, soak for 48 hours, add water and bo...

Technical field:

[0001] The invention relates to the technical field of medicine, in particular to an anti-tumor traditional Chinese medicine composition and a preparation method thereof. Background technique:

[0002] Gastric cancer is one of the malignant tumors with high recurrence and metastasis, and the five-year survival rate is still low. Postoperative treatment of gastric cancer currently includes chemotherapy, immunotherapy, biological therapy, etc. A variety of anti-tumor chemotherapy drugs have been used in the treatment of gastric cancer, but the curative effect on recurrence and metastasis is not satisfactory, and the side effects are relatively large. Traditional Chinese medicine therapy has its own advantages in the treatment of tumors, prolongs the survival time, improves the quality of life, and has the characteristics of safety and low toxicity. Conversely, theories and methods are different, so a variety of anti-tumor traditional Chinese medicine preparat...

Examples

Embodiment 1

[0023] Take the following proportioning medicinal materials:

[0024] Pinellia 150g Nanxing 150g Shan Cigu 300g Scorpion 30g

[0025] Centipede 150g Tianlong 150g Toad Shell 90g Aesculus Aesculus 300g

[0026] 300g snakeberry fried chicken gold 60g agarwood 60g roasted licorice 60g

[0027] Scorpion, centipede, Tianlong, toad shells are crushed into coarse powder according to the ratio, add 1500ml of water and soak for 24 hours, according to the percolation method under flow extract and extract, use 70% ethanol to percolate, collect the filtrate, Ethanol was recovered from the filtrate, allowed to stand, and filtered for later use. Add 1000ml of water to the medicinal dregs, decoct twice for 1 hour each time, combine the decoction, filter, combine the filtrate with the above aqueous solution, concentrate under reduced pressure at 0.8kpa to 500ml for later use.

[0028] Add 2000ml of water to Nanxing, Pinellia, and Arrowhead, soak for 24 hours, add water and boil for 2 hours...

Embodiment 2

[0031] Take the following proportioning medicinal materials:

[0032] Pinellia 90g Nanxing 90g Scorpion 30g

[0033] Centipede 90g Tianlong 90g Toad Shell 90g Aescin 150g

[0034] 150g snakeberry fried chicken gold 60g agarwood 30g roasted licorice 30g

[0035] Scorpion, centipede, Tianlong, toad shells are crushed into coarse powder according to the ratio, and after adding 1000ml of water to soak for 48 hours, according to the percolation method under flow extract and extract, percolate with 50% ethanol, collect the percolation, Ethanol was recovered from the filtrate, allowed to stand, and filtered for later use. Add 1000ml of water to the dregs, decoct 3 times, 1 hour each time, combine the decoction, filter, combine the filtrate with the above aqueous solution, concentrate under reduced pressure at 0.8kpa to 500ml for later use.

[0036] Add 1000ml of water to Nanxing and Pinellia, soak for 48 hours, add water to decoct for 2 hours, collect the decoction, filter and set...

Embodiment 3

[0039] Take the following proportioning medicinal materials:

[0040]Pinellia 150g Nanxing 150g Shan Cigu 150g Scorpion 60g

[0041] Centipede 150g Tianlong 150g Toad Shell 90g Aesculus Aesculus 300g

[0042] 150g snakeberry fried chicken gold 30g agarwood 60g roasted licorice 30g

[0043] Scorpion, centipede, dragon, and toad shells are crushed into coarse powder according to the proportion, and after adding 1500ml of water to soak for 48 hours, according to the percolation method under the flow extract and extract, use 80% ethanol to percolate, collect the percolation, Ethanol was recovered from the filtrate, allowed to stand, and filtered for later use. Add 1000ml of water to the dregs, decoct 3 times, 1 hour each time, combine the decoction, filter, combine the filtrate with the above aqueous solution, concentrate under reduced pressure at 0.8kpa to 500ml for later use.

[0044] Add 2000ml of water to Nanxing, Pinellia, and Arrowhead, soak for 48 hours, add water and bo...

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