Preparation method of 3-(2-pyridine amino) ethyl propionate

Abstract

The invention discloses a preparation method of 3-(2-pyridine amino) ethyl propionate. The preparation method comprises that 2-aminopyridine and ethyl acrylate serve as raw materials, in inorganic solvent or organic solvent, Bronsted acid serves as a catalyst, the temperature is controlled between 80 DEG C and 120 DEG C through oil bath heating so that a catalytic reaction is conducted, vacuum concentration is conducted to the obtained reaction liquid under the temperature between 40 DEG C and 45 DEG C and the pressure is between 0.09MPa and 0.1MPa, chromatography is conducted to concentrated solution by silicagel columns or sesquioxide uranium aluminum posts so as to obtain the 3-(2-pyridine amino) ethyl propionate. The preparation method of the 3-(2-pyridine amino) ethyl propionate has the advantages of being simple in preparation method, convenient to operate, low in production cost and short in reaction time, the product yield of the obtained 3-(2-pyridine amino) ethyl propionate reaches between 50% and 76%.

Description

technical field

[0001] The invention relates to a preparation method of ethyl 3-(2-pyridylamino)propionate. Background technique

[0002] 3-(Pyridin-2-ylamino) ethyl propionate is one of the important intermediates in the synthesis of direct thrombin inhibitor dabigatran etexilate (trade name: Pradaxa). Dabigatran etexilate is the first new class of oral anticoagulant drugs marketed 50 years after warfarin. Compared with warfarin, dabigatran etexilate has the characteristics of oral administration, rapid onset of action, no need for special drug monitoring, and less drug interaction. In vivo, in vitro tests and clinical studies have shown that it has good curative effect and pharmacokinetics. It has good clinical application prospect. Schematic diagram of the structure such as figure 1 The listing of dabigatran etexilate as shown is a major progress in the field of anticoagulant therapy and the prevention of potentially fatal thrombosis, which is of milestone significance...

Examples

Embodiment 1

[0028] A kind of preparation method of 3-(2-pyridine amino) propionate ethyl ester, promptly take 2-aminopyridine and ethyl acrylate as raw material, under the condition of solvent-free, take p-toluenesulfonic acid as catalyst, control temperature is 100 Reaction at ℃ for 24h, the reaction to obtain ethyl 3-(2-pyridylamino)propionate, the specific steps are as follows:

[0029] Add 2-aminopyridine (0.47g, 5mmol) and ethyl acrylate (1.0g, 10mmol) in a 25mL round bottom flask or a 15mL sealed tube, and add p-toluenesulfonic acid (0.5mmol, 10mol%) ) as a catalyst, and the temperature was controlled to react at 100°C for 24h. The resulting reaction solution is concentrated under reduced pressure at a temperature of 40-45°C and a pressure of 0.09-0.1 MPa, and the concentrated solution is passed through a silica gel column or an aluminum oxide column with a ratio of petroleum ether:ethyl acetate of 8:1 to 5 After the eluent at 1:1 was subjected to column chromatography, the eluent ...

Embodiment 2

[0034] A preparation method of ethyl 3-(2-pyridineamino) propionate, which is to use 2-aminopyridine and ethyl acrylate as raw materials, under solvent-free conditions, use nitric acid as a catalyst, and react at a controlled temperature of 100°C 24h obtains 3-(2-pyridylamino) ethyl propionate, and concrete steps are as follows:

[0035] Add 2-aminopyridine (0.47g, 5mmol) and ethyl acrylate (1.0g, 10mmol) into a 25mL round-bottom flask or a 15mL sealed tube, and use nitric acid (0.5mmol, 10mol%) as a catalyst under solvent-free conditions, React at 100°C for 24h. The resulting reaction solution is concentrated under reduced pressure at a temperature of 40-45°C and a pressure of 0.09-0.1 MPa, and the concentrated solution is passed through a silica gel column or an aluminum oxide column with a ratio of petroleum ether:ethyl acetate of 8:1 to 5 After the eluent of 1:1 was subjected to column chromatography, the eluent of 5:1 was collected, and the white solid obtained by spinni...

Embodiment 3

[0037] A kind of preparation method of 3-(2-pyridineamino) propionate ethyl ester, promptly take 2-aminopyridine and ethyl acrylate as raw material, under the condition of solvent in ethanol, take p-toluenesulfonic acid as catalyzer, control temperature is Reaction at 100°C for 24h to obtain ethyl 3-(2-pyridylamino)propionate, the specific steps are as follows:

[0038]2-Aminopyridine (0.47g, 5mmol) and ethyl acrylate (1.0g, 10mmol) were added to a 25mL round-bottomed flask or a 15mL sealed tube, and under the condition of ethanol (1mL) as a solvent, p-toluenesulfonic acid ( 0.5mmol, 10mol%) as the catalyst, the reaction temperature is controlled at 100°C for 24 hours respectively, and the obtained reaction liquid is concentrated under reduced pressure at a temperature of 40-45°C and a pressure of 0.09-0.1MPa, and the concentrated liquid is passed through a silica gel column Or aluminum oxide column is equipped with petroleum ether: the eluent of ethyl acetate ratio is 8:1 to ...

technical field

[0001] The invention relates to a preparation method of ethyl 3-(2-pyridylamino)propionate. Background technique

[0002] 3-(Pyridin-2-ylamino) ethyl propionate is one of the important intermediates in the synthesis of direct thrombin inhibitor dabigatran etexilate (trade name: Pradaxa). Dabigatran etexilate is the first new class of oral anticoagulant drugs marketed 50 years after warfarin. Compared with warfarin, dabigatran etexilate has the characteristics of oral administration, rapid onset of action, no need for special drug monitoring, and less drug interaction. In vivo, in vitro tests and clinical studies have shown that it has good curative effect and pharmacokinetics. It has good clinical application prospect. Schematic diagram of the structure such as figure 1 The listing of dabigatran etexilate as shown is a major progress in the field of anticoagulant therapy and the prevention of potentially fatal thrombosis, which is of milestone significance...

Examples

Embodiment 1

[0028] A kind of preparation method of 3-(2-pyridine amino) propionate ethyl ester, promptly take 2-aminopyridine and ethyl acrylate as raw material, under the condition of solvent-free, take p-toluenesulfonic acid as catalyst, control temperature is 100 Reaction at ℃ for 24h, the reaction to obtain ethyl 3-(2-pyridylamino)propionate, the specific steps are as follows:

[0029] Add 2-aminopyridine (0.47g, 5mmol) and ethyl acrylate (1.0g, 10mmol) in a 25mL round bottom flask or a 15mL sealed tube, and add p-toluenesulfonic acid (0.5mmol, 10mol%) ) as a catalyst, and the temperature was controlled to react at 100°C for 24h. The resulting reaction solution is concentrated under reduced pressure at a temperature of 40-45°C and a pressure of 0.09-0.1 MPa, and the concentrated solution is passed through a silica gel column or an aluminum oxide column with a ratio of petroleum ether:ethyl acetate of 8:1 to 5 After the eluent at 1:1 was subjected to column chromatography, the eluent ...

Embodiment 2

[0034] A preparation method of ethyl 3-(2-pyridineamino) propionate, which is to use 2-aminopyridine and ethyl acrylate as raw materials, under solvent-free conditions, use nitric acid as a catalyst, and react at a controlled temperature of 100°C 24h obtains 3-(2-pyridylamino) ethyl propionate, and concrete steps are as follows:

[0035] Add 2-aminopyridine (0.47g, 5mmol) and ethyl acrylate (1.0g, 10mmol) into a 25mL round-bottom flask or a 15mL sealed tube, and use nitric acid (0.5mmol, 10mol%) as a catalyst under solvent-free conditions, React at 100°C for 24h. The resulting reaction solution is concentrated under reduced pressure at a temperature of 40-45°C and a pressure of 0.09-0.1 MPa, and the concentrated solution is passed through a silica gel column or an aluminum oxide column with a ratio of petroleum ether:ethyl acetate of 8:1 to 5 After the eluent of 1:1 was subjected to column chromatography, the eluent of 5:1 was collected, and the white solid obtained by spinni...

Embodiment 3

[0037] A kind of preparation method of 3-(2-pyridineamino) propionate ethyl ester, promptly take 2-aminopyridine and ethyl acrylate as raw material, under the condition of solvent in ethanol, take p-toluenesulfonic acid as catalyzer, control temperature is Reaction at 100°C for 24h to obtain ethyl 3-(2-pyridylamino)propionate, the specific steps are as follows:

[0038]2-Aminopyridine (0.47g, 5mmol) and ethyl acrylate (1.0g, 10mmol) were added to a 25mL round-bottomed flask or a 15mL sealed tube, and under the condition of ethanol (1mL) as a solvent, p-toluenesulfonic acid ( 0.5mmol, 10mol%) as the catalyst, the reaction temperature is controlled at 100°C for 24 hours respectively, and the obtained reaction liquid is concentrated under reduced pressure at a temperature of 40-45°C and a pressure of 0.09-0.1MPa, and the concentrated liquid is passed through a silica gel column Or aluminum oxide column is equipped with petroleum ether: the eluent of ethyl acetate ratio is 8:1 to ...

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