Antibacterial polypyrrole/sulfosalicylic acid nanorod and preparation method and application thereof

Abstract

The invention belongs to the technical field of medical biomaterials and discloses an antibacterial polypyrrole / sulfosalicylic acid nanorod and a preparation method and application thereof. The methodcomprises that through a three-electrode system with a metal material as a working electrode, a mixed solution of a pyrrole monomer and sulfosalicylic acid as an electrolyte solution undergo a polymerization reaction on the surface of the working electrode through an electrochemical constant current method to produce a polypyrrole / sulfosalicylic acid nanorod, wherein the mixed solution of a pyrrole monomer and sulfosalicylic acid is obtained by dissolving a pyrrole monomer and sulfosalicylic acid in a phosphate buffer solution. The polypyrrole / sulfosalicylic acid nanorod is produced on the surface of the working electrode so that surface biological activity and antibacterial performances are improved. The preparation method has simple processes and a stable structure and has a potential application value in the field of the biological material.

Description

technical field

[0001] The invention belongs to the technical field of medical biological materials, and relates to a polypyrrole / sulfosalicylic acid nanorod with antibacterial properties and a preparation method and application thereof. Background technique

[0002] Medical titanium and its alloys are commonly used hard tissue implant materials in clinical practice. They have good biocompatibility, mechanical properties and machining properties, and are ideal hard tissue replacement materials. However, an inert biological layer is easily formed on the surface of pure titanium, and there are problems such as poor biological activity and poor antibacterial properties, which restrict the application and development of titanium and its alloy bone repair materials. In order to improve the antibacterial performance of titanium and its alloy materials, the current main research approach is to construct silver ion-loaded or antibiotic coatings. Although silver-ion-loaded antibacte...

Examples

Embodiment 1

[0030] A preparation method of antibacterial polypyrrole / sulfosalicylic acid nanorods, comprising the following steps:

[0031] (1) Pretreatment of the titanium sheet: Soak the electrode material titanium sheet in 1mol / L hydrochloric acid for 10 minutes to remove the surface oxide layer, and then ultrasonically clean it in deionized water, absolute ethanol and acetone for 20 minutes to remove the oil on the surface and other impurities, after vacuum drying;

[0032] (2) Select a three-electrode system, use the titanium sheet after step (1) as the working electrode, the copper sheet as the counter electrode, and the saturated calomel electrode as the reference electrode, and use the mixed solution of pyrrole monomer and sulfosalicylic acid As an electrolyte solution, by electrochemical constant current method (the current density is 0.6mA / cm 2 , the reaction time is 10min, and the temperature of the reaction is normal temperature), polymerized on the surface of the working ele...

Embodiment 2

[0040] A preparation method of antibacterial polypyrrole / sulfosalicylic acid nanorods, comprising the following steps:

[0041] (1) Pretreatment of the titanium sheet: Soak the electrode material titanium sheet in 1mol / L hydrochloric acid for 10 minutes to remove the surface oxide layer, and then ultrasonically clean it in deionized water, absolute ethanol and acetone for 20 minutes to remove the oil on the surface and other impurities, after vacuum drying;

[0042] (2) Select a three-electrode system, use the titanium sheet after step (1) as the working electrode, the copper sheet as the counter electrode, and the saturated calomel electrode as the reference electrode, and use the mixed solution of pyrrole monomer and sulfosalicylic acid As an electrolyte solution, by electrochemical constant current method (the current density is 0.7mA / cm 2 , the reaction time is 10min, and the reaction temperature is 25°C), polymerize on the surface of the working electrode to obtain polyp...

Embodiment 3

[0045] An antibacterial polypyrrole / sulfosalicylic acid nanorod and a preparation method thereof, comprising the following steps:

[0046] (1) Pretreatment of the titanium sheet: soak the electrode material titanium sheet in 1 mol / L hydrochloric acid for 10 minutes to remove the surface oxide layer, and then ultrasonically clean it in deionized water, absolute ethanol and acetone for 30 minutes in turn to remove the oil on the surface. and other impurities, use after vacuum drying;

[0047] (2) Selecting a three-electrode system, using the titanium sheet treated in step (1) as the working electrode, the copper sheet as the counter electrode, the saturated calomel electrode as the reference electrode, and using the mixed solution of pyrrole monomer and sulfosalicylic acid It is an electrolyte solution by electrochemical constant current method (current density is 1.5mA / cm 2 , the reaction time was 10 min, and the reaction temperature was 25 °C), polypyrrole / sulfosalicylic acid n...

technical field

[0001] The invention belongs to the technical field of medical biological materials, and relates to a polypyrrole / sulfosalicylic acid nanorod with antibacterial properties and a preparation method and application thereof. Background technique

[0002] Medical titanium and its alloys are commonly used hard tissue implant materials in clinical practice. They have good biocompatibility, mechanical properties and machining properties, and are ideal hard tissue replacement materials. However, an inert biological layer is easily formed on the surface of pure titanium, and there are problems such as poor biological activity and poor antibacterial properties, which restrict the application and development of titanium and its alloy bone repair materials. In order to improve the antibacterial performance of titanium and its alloy materials, the current main research approach is to construct silver ion-loaded or antibiotic coatings. Although silver-ion-loaded antibacte...

Examples

Embodiment 1

[0030] A preparation method of antibacterial polypyrrole / sulfosalicylic acid nanorods, comprising the following steps:

[0031] (1) Pretreatment of the titanium sheet: Soak the electrode material titanium sheet in 1mol / L hydrochloric acid for 10 minutes to remove the surface oxide layer, and then ultrasonically clean it in deionized water, absolute ethanol and acetone for 20 minutes to remove the oil on the surface and other impurities, after vacuum drying;

[0032] (2) Select a three-electrode system, use the titanium sheet after step (1) as the working electrode, the copper sheet as the counter electrode, and the saturated calomel electrode as the reference electrode, and use the mixed solution of pyrrole monomer and sulfosalicylic acid As an electrolyte solution, by electrochemical constant current method (the current density is 0.6mA / cm 2 , the reaction time is 10min, and the temperature of the reaction is normal temperature), polymerized on the surface of the working ele...

Embodiment 2

[0040] A preparation method of antibacterial polypyrrole / sulfosalicylic acid nanorods, comprising the following steps:

[0041] (1) Pretreatment of the titanium sheet: Soak the electrode material titanium sheet in 1mol / L hydrochloric acid for 10 minutes to remove the surface oxide layer, and then ultrasonically clean it in deionized water, absolute ethanol and acetone for 20 minutes to remove the oil on the surface and other impurities, after vacuum drying;

[0042] (2) Select a three-electrode system, use the titanium sheet after step (1) as the working electrode, the copper sheet as the counter electrode, and the saturated calomel electrode as the reference electrode, and use the mixed solution of pyrrole monomer and sulfosalicylic acid As an electrolyte solution, by electrochemical constant current method (the current density is 0.7mA / cm 2 , the reaction time is 10min, and the reaction temperature is 25°C), polymerize on the surface of the working electrode to obtain polyp...

Embodiment 3

[0045] An antibacterial polypyrrole / sulfosalicylic acid nanorod and a preparation method thereof, comprising the following steps:

[0046] (1) Pretreatment of the titanium sheet: soak the electrode material titanium sheet in 1 mol / L hydrochloric acid for 10 minutes to remove the surface oxide layer, and then ultrasonically clean it in deionized water, absolute ethanol and acetone for 30 minutes in turn to remove the oil on the surface. and other impurities, use after vacuum drying;

[0047] (2) Selecting a three-electrode system, using the titanium sheet treated in step (1) as the working electrode, the copper sheet as the counter electrode, the saturated calomel electrode as the reference electrode, and using the mixed solution of pyrrole monomer and sulfosalicylic acid It is an electrolyte solution by electrochemical constant current method (current density is 1.5mA / cm 2 , the reaction time was 10 min, and the reaction temperature was 25 °C), polypyrrole / sulfosalicylic acid n...

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