41results about How to "Weak side effects" patented technology

The invention discloses a high-fluidity polyphenylene ether sulfone ketone (PPSUK) resin which is implemented through introducing an aromatic ketone monomer, especially a heterogeneous aromatic ketone monomer copolymer, into a PPSU polymer, so that the main chain of an obtained copolymer molecule contains a polyether sulphone and polyaryletherketone random copolymer structure, wherein the molar ratio of groups is (5-9):1. The machine-shaping temperature of a polymer prepared by using the method disclosed by the invention is usually not higher than 350 DEG C, and the polymer is high in fluidity and easy to machine, and has excellent solvent resistance, thereby expanding the product application field.

The invention discloses an industrial synthesis method of high-thermal-stability blocked binphenyl-structure-containing polyaryletherketone resin. The industrial synthesis method of the high-thermal-stability blocked binphenyl-structure-containing polyaryletherketone resin comprises the following steps: carrying out polymerization reaction based on paradioxybenzene, biphenol and 4,4'-difluoro diphenyl ketone or 4,4'-difluoro triphenyl diketone as reaction monomers, a high boiling point organic solvent as a solvent, alkali carbonate as a salt-forming agent and asymmetric aromatic ketone-based derivative as a blocking agent, so as to obtain polymerization mucosal fluid; cooling the polymerization mucosal fluid and smashing the cooled polymerization mucosal fluid into powder, filtering and boiling and washing with an organic solvent and deionized water for removing the solvent and byproduct salt, and drying, thus obtaining the binphenyl-structure-containing polyaryletherketone resin. The industrial synthesis method of the high-thermal-stability blocked binphenyl-structure-containing polyaryletherketone resin has the advantages that sodium carbonate alkali metal is individually adopted as a catalyst, and a good blocking effect is realized after the blocking agent is added; besides, no polymerization phenomenon is caused in a system, and the obtained blocked binphenyl-structure-containing polyaryletherketone resin has high temperature thermal stability.

The invention discloses a high-fluidity polyethersulfoneketone (PESK) resin. Aromatic ketone monomers (especially heterogeneous aromatic ketone monomers) are introduced into a PES polymer to carry out copolymerization reactions so as to obtain the high-fluidity polyethersulfoneketone resin, whose main chain comprises a random copolymerization structure composed of poly(aryl ether sulfone) and poly(aryl ether ketone), wherein the mole ratio of poly(aryl ether sulfone) group to poly(aryl ether ketone) group is in a range of (5 to 9):1. The processing temperature and molding temperature of the PESK resin is usually not higher than 350 DEG C; the PESK resin has a high fluidity, is easy to process, and has an excellent solvent-resistant performance; so the product application area is enlarged.

The invention discloses the application of spermidine in the preparation of medicine for treating aortic aneurysm. The beneficial effect of the present invention is that the spermidine can be used as a drug for delaying the progress of abdominal aortic aneurysm, and the drug has achieved good therapeutic effects in animal experiments, has relatively clear toxicology and pharmacology, high safety, and weak toxic and side effects.

The invention discloses glass fiber-enhanced chain-extending modified polyether sulphone resin and a preparation method therefor. The preparation method comprises the step of mixing and extruding the following: 50-90% of chain-extending polyether sulfone resin (PPSU, PES); 9-40% of fiber; 0.1-5% of carbon black or titanium dioxide; and 0.1-10% of various auxiliary agents. The synthetic process disclosed by the invention is simple and the production efficiency is high. The synthesized novel chain-extending modified polyether sulphone resin has higher mechanical strength and lower melt viscosity, and is more liable to be processed and moulded. Meanwhile, the fiber-modified and enhanced polyether sulphone resin is good in flowability and heat resistance, and the mechanical properties of the enhanced resin such as tensile strength, bending strength and toughness are improved to a great extent, so that the application field of the polyether sulphone material is widened.

The invention discloses an industrialized synthesis method of a high-heat-stability blocked polyether sulfone resin, which comprises the following steps: in a reaction kettle in a nitrogen protective atmosphere, adding a sulfolane solvent, heating to 60-80 DEG C while stirring, sequentially adding a water diversion agent, continuing heating to 200-210 DEG C while stirring, and carrying out salifying reaction for 1-2 hours; after the salifying reaction is finished, heating to 220-240 DEG C, carrying out constant-temperature polymerization reaction for 1-2 hours, adding a blocking agent, and continuing the reaction for 10-30 minutes to obtain a polymerization slurry; and cooling the polymerization slurry, pulverizing into powder, filtering, boiling and washing with deionized water to remove the solvent and byproduct salts, and drying to obtain the polyether sulfone resin. After adding the blocking agent, the polyether sulfone resin has favorable blocking effect, the system does not have the phenomenon of depolymerization, and the obtained blocked polyether sulfone resin has high heat stability; and the technique can greatly shorten the reaction time and enhance the productivity.

The invention provides a main drug component composition, a slow-controlled-release pharmaceutical preparation, and a preparation method and application thereof for treating sore carbuncles, burns and scalds and acne. The main medicinal composition for treating carbuncle, burn and acne includes Kochia kohlrabi extract, Centella asiatica extract and borneol, based on the total weight of the composition, the Kochia kohlrabi extract The content of the extract is 40-75% by weight, the content of the Centella asiatica extract is 20-50% by weight, and the content of the borneol is 1-10% by weight. The main drug has the functions of expelling wind and relieving itching, detoxification and swelling, clearing heat and dispelling knots. It is non-irritating and has stable drug release. It can relieve inflammation and reduce scars caused by inflammatory reactions.

The invention belongs to the field of biomedicine, in particular to a short peptide targeting IKKβ and its application in inflammatory diseases. In order to provide a more effective treatment for inhibiting inflammatory responses, the present application provides a short peptide targeting IKKβ, the short peptide includes the N-terminal amino acid 46-60 region derived from the IκB kinase binding protein IKIP, and the N-terminal of the short peptide is fused through Membrane peptides, with peptide tags. The short peptide can target IKKβ, inhibit the combination of IKKβ and IKKγ, thereby inhibiting the formation of IKK complex, reducing the expression of inflammatory cytokines TNF-α and IL-6, and inhibiting the inflammatory response. Animal models have shown that short peptides can effectively treat arthritis and inflammatory bowel disease. Compared with the full-length protein, the short peptide has a small molecular weight, is easy to synthesize, has weak immunogenicity, and has relatively weak side effects; it has better absorption with cell-penetrating peptides, and is easy to track and observe with peptide tags, which is a great tool for clinical treatment of inflammatory diseases for reference.