41results about How to "Weak side effects" patented technology

The present invention discloses a coronary artery medicine coating scaffold for inhibiting endometrial hyperplasia and preventing restenosis in the scaffold. It includes dilating scaffold base body and inner coating layer coated on the dilating scaffold base body, the above-mentioned inner coating layer is formed from medicine carrier and ligustrazine, their mass ratio is 3:1-1:3, the above-mentioned inner coating layer is one of methyl acrylate, methyl methacrylate copolymer, polylactic acid, polyglycollic acid, polymonoracemic lactic acid, polylactide-diglycolide polymer, phosphorylcholine, ethyl polyurethane inorganic micropore aluminium oxide and cellulose or their composite.

The invention discloses high-liquidity poly(ether sulfone ketone) (PESK) resin. Aromatic ketone monomers are introduced into a poly(ether sulfone) (PES) polymer, and particularly heterogeneous aromatic ketone monomers are copolymerized; and the main chain of the obtained polymer molecule contains an irregular copolymer structure of polyarylether sulfone and polyaryletherketone, wherein the molar ratio of the groups is (5-9):1. An industrial production process of the high-liquidity PESK resin consists of a salifying stage and a polymerization stage, wherein the solid content of the system in the salifying stage is 20-25%; and the solid content in the polymerization stage is 35-45%. By adopting the process provided by the invention, the processing forming temperature of the obtained polymer is generally not higher than 350 DEG C, the polymer has relatively high liquidity and is easy to process; and moreover, the solvent resistance is excellent, and the application fields of the product are widened.

The invention discloses fiber-reinforced type polyether sulphone alloy blended and modified resin and a preparation method thereof. The preparation method comprises the steps of mixing 20-75% of chain-extending polyether sulphone resin (PPSU, PES), 5-45% of polysulfone resin PSU, 10-40% of fibers, 0.1-5% of carbon black or titanium dioxide or a mixture of carbon black and titanium dioxide and 0.1-10% of various auxiliary agents, conducting extrusion, and obtaining the fiber-reinforced type polyether sulphone alloy blended and modified resin. The novel chain-extending polyether sulphone resin synthesized through the method is higher in mechanical strength, lower in melt viscosity and easier to process and form, an alloy material obtained by blending the fiber-modified-and-reinforced polyether sulphone resin and the polysulfone resin is good in flowability and heat resistance, mechanical properties of the reinforced alloy material such as tensile strength, bending strength and toughness are all substantially improved, and the application field of polyether sulphone series materials is expanded.

The invention discloses a high-fluidity polyethersulfoneketone (PESK) resin. Aromatic ketone monomers (especially heterogeneous aromatic ketone monomers) are introduced into a PES polymer to carry out copolymerization reactions so as to obtain the high-fluidity polyethersulfoneketone resin, whose main chain comprises a random copolymerization structure composed of poly(aryl ether sulfone) and poly(aryl ether ketone), wherein the mole ratio of poly(aryl ether sulfone) group to poly(aryl ether ketone) group is in a range of (5 to 9):1. The processing temperature and molding temperature of the PESK resin is usually not higher than 350 DEG C; the PESK resin has a high fluidity, is easy to process, and has an excellent solvent-resistant performance; so the product application area is enlarged.

The invention discloses an aqueous zinc ion battery positive electrode material, a preparation method thereof and an aqueous zinc ion battery. The aqueous zinc ion battery positive electrode material comprises an inner core and a coating layer, wherein the inner core comprises MnO, the coating layer is formed on the outer surface of the inner core, and the coating layer comprises carbon. Therefore, the aqueous zinc ion positive electrode material is stable in structure and high in specific capacity, and an aqueous zinc ion battery prepared from the aqueous zinc ion positive electrode material is good in electrochemical performance, high in specific capacity and good in cycle performance.

The invention discloses a star type polysulfone resin industrial synthesis method. Reinforced polysulfone resin is prepared through molecular design, excellent performance of original polysulfone is kept, melt viscosity of polysulfone is greatly reduced due to introduction of aromatic polyphenol, processing and forming are easier, thermal stability is higher, and the actual application field of polysulfone is greatly expanded. According to the method, the use amount of a key solvent of N-methyl pyrrolidone can be greatly reduced by controlling the solid content in the salifying stage and the polymerization stage and increasing the solid content in the polymerization stage, and cost is reduced.

The present invention relates to medicine, and is especially one kind of blood fat reducing Chinese medicine capsule prepared with red peony root, red sage, prepared fleeceflower root, and haw in the weight ratio of 1-1.5 to 1-1.5 to 1 to 1. The Chinese medicine capsule is used in preventing and treating hyperlipemia, atherosclerosis and other diseases. The Chinese medicine capsule possesses the functions of promoting blood circulation to disperse blood clots and reducing blood fat.

The invention provides the use of retinoic acid and its analogs in the preparation of medicines for treating mammals including human tumors caused by TSC1/TSC2 inactivation or activation of its upstream pathway. The invention also provides retinoic acid and its analogs and mTOR Use of the pharmaceutical composition composed of pathway inhibitors in the preparation of medicines for treating tumors in mammals including humans caused by TSC1/TSC2 inactivation or activation of upstream pathways. The invention provides a new approach for the treatment of tumors caused by TSC1/TSC2 inactivation.

The invention discloses a synthesis method of high-transparency polysulfone (PSU) resin containing cycloalkyl group substituted phenol. The method includes the steps of adding organic solvent in a nitrogen-protected reaction kettle with 4,4'-dichlorodiphenyi sulfone and bisphenol A as reaction monomers, wherein the mole ratio of 4,4'-dichlorodiphenyi sulfone to bisphenol A is 1 to 1; conducting stirring and temperature raising, sequentially adding the reaction monomers, adding a salt-forming agent and a water separation agent after all the monomers are dissolved, conducting stirring and temperature raising, and conducting the salt forming reaction for 1-2 hours; raising the temperature after the reaction ends, adding cycloalkyl group substituted phenol with the concentration of 0.1-5%, and conducting constant-temperature polymerization reaction for 4-5 hours to obtain polymerization mucus; cooling, smashing, washing and drying polymerization mucus to obtain the finished product. The method starts from the molecular structure level, cycloalkyl group substituted phenol is introduced into polymer molecular chains, the regularity of polymer chains is broken, the crystallization degree is lowered, and high-transparency polysulfone resin with ends capped by hydroxyl groups is prepared. The synthesized product keeps existing excellent performance of polysulfone, has the advantage of high light transmittance, and has better application prospects and great market value.

The invention provides a fusion vesicle derived from bacteria and plants as well as a preparation method and application of the fusion vesicle, and relates to the technical field of biomedicine. The fusion vesicle comprises a mixed membrane structure formed by fusing a bacterial outer membrane vesicle and a plant thylakoid membrane, wherein the bacteria are gram negative bacteria, and the plant thylakoid is a spinach thylakoid. The fusion vesicle of the present invention combines the characteristics of the bacterial outer membrane vesicle and the plant capsular membrane, the structure of the vesicle is uniform, the vesicle can efficiently and rapidly reach the tumor, the tumor targeting property is high, and the accumulation time is long; and the obvious effect is realized in the aspect of tumor treatment.

The invention discloses a traditional Chinese medicine compound composition capable of treating infantile constipation and a preparation method thereof. The traditional Chinese medicine compound composition is prepared from 6-15 parts of immature bitter orange, 6-15 parts of magnolia officinalis, 6-15 parts of snakegourd root, 6-15 parts of fructus forsythiae, 6-15 parts of medicated leaven, 6-15parts of fried cassia seed, 3-5 parts of rhubarb, and 3-9 parts of chicken's gizzard-membrane. The traditional Chinese medicine compound composition provided by the invention provides treatment according to differentiation of symptoms and signs on the basis of the theory of traditional Chinese medicine and has a scientific prescription according to the pathogenesis of infantile constipation; and experimental research results prove that the traditional Chinese medicine compound composition provided by the invention has scientific and reasonable proportion of each component, can obviously improve the activity of pepsin in rats, has a promoting effect on a propulsion function of small intestines in mice, and can reduce serum SS of the mice, and increase MTL and GAS, thereby regulating gastrointestinal hormones and promoting gastrointestinal peristalsis. Moreover, clinical experimental results show that the traditional Chinese medicine compound composition has a very good therapeutic effect on infantile constipation, and has good safety and no toxic or side effects.

The invention discloses a nitrate NO donor type tripyridine bisoxazole compound as well as a preparation method and application thereof. The structural formula of the nitrate NO donor type tripyridinebisoxazole compound is shown as a formula (I) in the description, wherein in the formula (I), n is 1 or 2. The nitrate NO donor type tripyridine bisoxazole compound disclosed by the invention shows targeted combination with a G-quadruplex and basically does not generate a combination effect with double helix DNA, so that targeted release of NO in tumor cells is realized, NO and a flexible G-quadruplex ligand generate a synergistic anti-tumor effect, and only weak toxic and side effects are generated. Theoretical and experimental bases are provided for developing novel anti-tumor drugs with high selectivity, high efficiency and low toxic and side effects on the basis of double functions of targeting G-quadruplex and releasing NO.