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An effervescence tablet of cold-treating preparation and preparation method thereof

A technology for effervescent tablets and preparations, which is applied in the directions of pill delivery, pharmaceutical formulations, anti-infective drugs, etc., can solve the problems of few types of lubricants, limited application, and harsh production conditions for effervescent tablets, and achieves easy portability and improved release. Speed, good taste

Inactive Publication Date: 2008-09-10
SUNSTONE TANGSHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, due to the harsh production conditions of effervescent tablets, the main performance is that the control of environmental humidity is particularly strict, and there are few suitable lubricants, which greatly limits the application of this type of dosage form.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A kind of cold preparation effervescent tablet suitable for children's patients, its prescription composition is as follows table 1:

[0037] Table 1

[0038] prescription composition

[0039] The resulting tablets weigh approximately 1.76 g each.

Embodiment 2

[0041] A cold preparation effervescent tablet suitable for children as in Example 1, the dosage range of each component is between ±5% as shown in Table 1.

Embodiment 3

[0043] A kind of cold preparation effervescent tablet preparation method suitable for children patient as embodiment 1, 2, comprises the steps:

[0044] After initial mixing of chlorpheniramine, tartrazine and a small amount of sodium chloride, sieve through a 100-mesh sieve and mix 3 times;

[0045] Add the remaining sodium chloride, aspartame, artificial bezoar, caffeine, amantadine hydrochloride and paracetamol, continue to sieve and mix 3 times;

[0046] Finally, add the acid source, alkali source and sucrose, mix well, take an appropriate amount of polyvinylpyrrolidone absolute ethanol solution with a concentration of 8% (w / v) as the binder for wet granulation; 45 ° C blast drying, after granulation, add PEG6000, and then compress the mixture into tablets at room temperature and relative humidity less than 40%, and the weight of the obtained tablet is about 1.76g.

[0047] Take about 150ml of distilled water at room temperature or 25°C, put 1 tablet into it and let it di...

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PUM

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Abstract

The invention relates to effervescent tablet for treating common cold which has good taste and rapid release speed, as well as the process for preparation, wherein the tablet comprises active constituents and effervescent materials, the active constituents include acetaminophen panadol, amantadine hydrochloride, caffeine, artificial ox gallstone and chlorpheniramine.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to an oral effervescent tablet dosage form, in particular to a compound paracetamol effervescent tablet which is convenient to carry and take, dissolves quickly and has a good taste. Background technique [0002] Flu is a kind of modal disease, has a strong impact on people's life and work. There are many medicines for treating colds, among which medicines containing paracetamol, amantadine hydrochloride, chlorpheniramine and other components are common cold preparations. [0003] The dosage forms of traditional cold medicines include capsules, tablets, granules, and oral liquids, etc., but these dosage forms have disadvantages such as slow drug release, inconvenient carrying, and bad taste, which are especially unacceptable to children. [0004] It is a better choice to use the effervescent tablet dosage form as the solid dosage form of cold medicine. After being made int...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/413A61K9/20A61K9/46A61P31/00A61P11/00A61K31/522A61K31/4402A61K31/13A61K31/167
Inventor 韩志强贾晓冬田乐昌安德清曾杏雪姜洪涛田英
Owner SUNSTONE TANGSHAN PHARM CO LTD
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