Methods for transmembrane treatment and prevention of otitismedia
A technology for the middle ear and tympanic membrane, applied in the field of transmembrane treatment and prevention of otitis media, which can solve pain, invasiveness and other problems
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Embodiment 1
[0044] This section provides examples of starting materials for the preparation of ciprofloxacin-containing transmembrane carrier compositions of the present invention. The transmembrane carrier composition included liposomes and contained the following ingredients with the listed w / w percentages.
Embodiment 2
Exemplary Process for Manufacturing Formulation A
[0045] This section provides an example of how to make a transmembrane carrier composition of the invention comprising ciprofloxacin.
[0046] water box. The method is preferably carried out with two jacketed stainless steel vortex hydration chambers. In the larger of the two compartments, slowly mix the pure water and benzethonium chloride to avoid the formation of foam or surface air bubbles. Heat was applied to reach a target temperature of 50°C ± 2°C for the aqueous phase. The chamber is covered to prevent water evaporation and is equipped with bottom ports and valves to regulate the flow of material out of the container.
[0047] fat phase. A second stainless steel jacketed mixing vessel was applied next to the first vessel. In this second chamber, first slowly mix the dehydrated alcohol and propylene glycol to avoid the formation of foam or surface air bubbles. Start the upper mixer and apply heat to reach 58±2°C, ...
Embodiment 3
Treatment of otitis media with an exemplary formulation
[0050] For the treatment of middle ear infections and their sequelae in infected individuals, the drug-containing liposomes according to the invention are administered to patients by transmembrane administration to the eardrum. Medications are those useful in the prevention and / or treatment of middle ear infections and are antibiotics, antivirals or pain relievers such as non-steroidal anti-inflammatory drugs.
[0051] Transmembrane administration is accomplished by, for example, applying a transmembrane carrier composition of the invention to the tympanic membrane with a needle-free syringe or other device suitable for medical insertion into the ear canal. Administration is repeated as necessary to obtain a therapeutically effective dosage level of the antibiotic compound administered. Pain can be treated in the same general manner by administering the transmembrane carrier compositions of the present invention contain...
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