Sugar-ferric hydroxide composite molecular weight and molecular weight distribution determination method

Abstract

The invention discloses a sugar-ferric-hydroxide compound molecular weight and molecular weight distribution test method. The invention uses high-effect gel filter spectrum method, uses common correct method to draw standard curvature, while the molecular weight standard material used for drawing standard curvature is polysaccharide molecular weight, the common standard curvature is corrected according to the K and alpha values of sugar-ferric-hydroxide compound and polysaccharide molecular weight, or uses high-effect gel filter spectrum, while the standard material used for drawing molecularweight standard curvature is a sugar-ferric-hydroxide compound standard material at different molecular weights, same as the object sugar-ferric-hydroxide compound, without correcting K and alpha values. The inventive method has low error, high accuracy, and avoids complex correction via using sugar-ferric-hydroxide compound.

Description

Method for determining molecular weight and molecular weight distribution of sugar-iron hydroxide complex Technical field The invention belongs to the field of molecular weight measurement, and relates to a sugar-iron hydroxide complex molecular weight and molecular weight distribution determination method, specifically the molecular weight of sugar-iron hydroxide complex represented by iron sucrose (sucrose-iron hydroxide complex) And its distribution method. Background technique Sugar-iron hydroxide complex is a widely used iron supplement for iron deficiency anemia, especially for iron deficiency anemia caused by hemodialysis in kidney diseases. The molecular weight and molecular weight distribution of this type of complex are one of the important indicators for evaluating its quality. Studies have found that the molecular weight and molecular weight distribution of sugar-iron hydroxide complexes are closely related to the pharmacological effects, clinical efficacy and iron...

AI Technical Summary

Problems solved by technology

This is very different from the linear structure of polysaccharides. If you directly use general polysaccharide molecular weight standards to measure the molecular weight and distribution of sugar-ferric hydroxide complexes, it will obviously bring a lot of errors, which is not conducive to the quality control of this type of products.

Images