A method and a system for assessing neurological conditions
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A neurological disease and nerve technology, applied in the field of generating neurological disease identification signals, can solve the problems of identification impossible, undisclosed identification objects, etc.
Inactive Publication Date: 2008-04-02
MENTIS CURA EHF
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[0006] However, this reference only discloses the concept of how two subjects with DAT can be discriminated from healthy subjects by the drug pentobarbital, where such discrimination is not possible without this drug
[0007] However, such references do not disclose how to identify objects from references at an early stage
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Embodiment 1
[0101] Suppose we have two reference groups, group A and group B, where f={1,2,3} is the feature group used, and N=2 is the combination parameter that determines the number of features to be combined (for example, two Features can be combined or three features, etc.). The group of all non-repetitive combinations of these features will be V = {(1, 2), (1, 3), (2, 3)}, that is, the first element is the combination of feature 1 and feature 2, and the second One is a combination of feature 1 and feature 3, etc. Based on the above, (1, 2) is the first characteristic, (1, 3) is the second characteristic, and (2, 3) is the third characteristic. Figures 3 to 5 exemplarily show the possible distribution of all reference objects in group A and group B. Figure 3 shows the statistical distribution of characteristics (1, 2) for groups A and B, where the reference objects in these groups are plotted based on ("1", "2") feature values (ie, "1" is Feature 1 value, "2" is feature 2 value). Area ...
Embodiment 2
[0106] The efficiency of the present invention has been verified in clinical trials. Participants were divided into two groups in this experiment. One group consisted of older subjects who had been diagnosed with mild to moderate Alzheimer's dementia (AD group). Another age-matched group consisting of 10 healthy individuals (ie non-AD individuals) served as the control group.
[0107] Participants in the AD group consisting of patients conducted a clinical follow-up survey of memory in the Department of Geriatrics at Landspitali University Hospital, Reykjavik, Iceland (Landspitali University Hospital, Reykjavik, Iceland). This group consisted of Alzheimer's patients (AD) (N=10) according to ICD-10. The other group consisted of control participants in the journey (N=10) who were recruited from relatives who participated in the day care center for dementia patients.
[0108] Why meet the criteria for participating in the study, these subjects need to be in the range of 60 to 80 year...
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Abstract
This invention relates to a method and a system for generating a discriminatory signal for a neurological condition, where at least one probe compound that has a neurophysiologic effect is provided. Biosignal data are obtained from a subject based on biosignal measurements obtained from biosignal measuring device adapted for placement on a subject, wherein said biosignal data are obtained posterior to the administering of said probe compound to the subject. Analogous biosignal reference data are provided for reference subjects in at least one reference group posterior to the administering of the probe compound, wherein the reference data are utilized for defining reference features having common characteristics between the reference subjects in the at least one reference group, wherein the reference data are processed for defining reference posterior probability vectors for each respective reference subject, wherein each respective posterior probability vector comprises particular feature or a feature combination elements with probability values associated to said elements, the posterior probability vectors resulting in a distribution of said features or feature combinations for said reference subjects. Subsequently, the biosignal data obtained from the subject are used for calculating analogues posterior probability vector for said subject. The discriminatory signal is then generated based on comparison between said posterior probability vector for said subject and the distribution of said features or feature combinations.
Description
Technical field [0001] The present invention relates to a method and system for generating a neurological disorder discrimination signal by using consistent reference data obtained from a reference object. Background technique [0002] US2003 / 0233250 discloses a method for providing a tool for interpreting data of biological data related to a patient through a network, where the biological data of the patient is collected at the tool, and a part of the data is transmitted to a storage device through the network . Next, at least one potential indicator variable related to the patient's biological data is determined and compared with a standard data set related to the health status. Based on the comparison, at least one indicator variable is selected, and a report including the indicator variable and at least one data interpretation tool related to the patient is generated for the health care provider. [0003] In this report evaluation program, the reports and indicators used to i...
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