Application of curcumin in preparing tumor multi-medicine drug-resistant prevention agent

Abstract

The present invention provides an application of curcumin in preparation of tumor multi-drug drug-resistance preventing preparation. Its CAS mumber is 458-37-7, molecular weight is 368.37, chemical name is 1,7-bis-(4-hydroxy- 3-methoxyphenyl)-1,6-heptadiene-3,5-dione and its molecular formula is C21H2006. The curcumin drug prepared by said invention includes preparation allowable drug excipient and carrier.

Description

technical field The invention belongs to the use of natural plant monomer compounds, and relates to the new use of curcumin extracted from plants, in particular to the use of curcumin in preparing a preventive agent for tumor multi-drug resistance. Background technique Multidrug Resistance (MDR) refers to the cross-resistance of tumor cells to other anti-tumor drugs with different structures and mechanisms of action while they are resistant to one anti-tumor drug, which is the main reason for the failure of chemotherapy. . P-glycoprotein (P-gp) is the most important drug resistance protein mediating tumor multidrug resistance, and is the main cause of MDR in chemotherapy. At present, most of the research on anti-tumor multidrug resistance is based on the mechanism of MDR and after the formation of MDR, it is reversed with a specific reversal agent. However, after many tumor cells develop drug resistance, the abundance of drug-resistant proteins is very low. High, strong d...

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Problems solved by technology

It has been reported that curcumin can reverse P-gp-mediated tumor MDR in human drug-resistant tumor cells, but there is no literature reporting that curcumin can prevent chemotherapeutic drug-induced drug resistance in human sensitive tumor cells

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