30results about How to "Improve chemotherapy efficacy" patented technology

The present invention provides an application of curcumin in preparation of tumor multi-drug drug-resistance preventing preparation. Its CAS mumber is 458-37-7, molecular weight is 368.37, chemical name is 1,7-bis-(4-hydroxy- 3-methoxyphenyl)-1,6-heptadiene-3,5-dione and its molecular formula is C21H2006. The curcumin drug prepared by said invention includes preparation allowable drug excipient and carrier.

The invention discloses a titanium oxide nanometer composite material. The titanium oxide nanometer composite material is characterized by comprising titanium oxide nanometer bubbles; the kernels of the titanium oxide nanometer bubbles are gas; the average grain size of the titanium oxide nanometer bubbles is 10-200 nm. The titanium oxide nanometer composite material can achieve multi-modal imaging, and synergic treatment of malignant tumor is achieved through a sensibilization effect of sonodynamic/ photodynamic/ optical heat and ultrasonic cavitation on chemotherapeutic drugs.

The invention provides a dissoluble microneedle carrying lipidosome cis-platinum nano-particles and a preparation method of the dissoluble microneedle. Through a reverse micro-emulsion method, a cis-platinum precursor higher in solubility is prepared, and the lipidosome nano-particles are prepared; multiple kinds of lipidosome wrap cis-platinum, targeted location of cancer cells is achieved, the nano-particles directly act on the cancer cells, the nano-particles are carried on a dissoluble microneedle, and the dissoluble microneedle is directly pasted on tumors exposed to the epidermis to improve the curative effect of chemotherapeutic drugs and reduce side effects. According to the lipidosome nano-particles prepared through the method, the solubility of cis-platinum is improved, the lipidosome nano-particles can be applied to various drugs hard to dissolve in water, and convenience is provided for manufacturing of the dissoluble microneedle. By means of the lipidosome nano-particles,the drug toxicity of the chemotherapeutic drugs on the cancer cells can be improved, and the side effects are reduced to a certain degree. The chemotherapeutic drugs are wrapped by the microneedle, local painless injection can be achieved, the anticancer effect is remarkably improved, and the side effects are reduced.

The invention relates to a pharmaceutical composition for treating the cancer and an application of the pharmaceutical composition. The pharmaceutical composition comprises methotrexate as an active ingredient and a BRD4 protein inhibitor, and the mass ratio of the methotrexate to the BRD4 protein inhibitor ranges from 10:1 to 1:8. The pharmaceutical composition obviously improves the chemotherapeutic effect of the methotrexate, the similar chemotherapeutic effect is achieved by using the methotrexate at the relatively low concentration, therefore, the toxicity on a nude mouth is obviously reduced, and the injury of the pharmaceutical composition on the organism is reduced, so that the pharmaceutical composition is applied to preparation of anti-tumor drugs.

The invention provides a design and preparation method for a multiple-response type nanodrug based on combined treatment. The design and preparation method comprises the following steps of: through graphene oxide, loading adriamycin and indocyanine green, then, coating the graphene oxide with gelatin, obtaining nanometer particles with an even size through a secondary emulsification method, and finally, carrying out crosslinking through N, N'-bis (acrylyl) cystamine to obtain the multiple-response type nanodrug. The design and preparation method adopts the gelatin as a nanoparticle shell, biocompatibility is improved, in addition, the multiple-response type nanodrug has size conversion capability, a penetration effect of the nanodrug on a tumor position is improved, the combined treatmentcan be realized through the graphene oxide, the adriamycin and the indocyanine green, and an anti-tumor effect is obviously improved.

The invention discloses a method for entrapment of a chemotherapeutic drug by using autologous organoid derived microbubbles of a tumor patient and application of the chemotherapeutic drug. The method comprises the following steps: (1) shearing autologous tumor tissues of a tumor patient, then carrying out enzyme digestion, then filtering digested tumor cells by using a filter screen, carrying out centrifugal collection, then uniformly mixing with matrigel, then adding an organoid culture medium for culturing, and collecting to obtain an organoid when the diameter of the organoid is 200-400 [mu] m; (2) performing ultraviolet stimulation on the organoid, adding a chemotherapeutic drug, incubating, collecting a culture solution, centrifuging to remove cells and fragments, and centrifuging and collecting to obtain drug-loaded organoid microbubbles; wherein the ultraviolet stimulation condition is that an ultraviolet lamp with the power being 8 W and the wavelength being 254 nm is used for irradiating for 30-90 min. The drug-loaded organoid microbubble constructed in the invention has a tumor targeting effect and a stronger tumor cell killing effect, and can be used for treating tumors.

The invention provides novel use of 24-acetyl alisol F (ALI). The 24-acetyl alisol F can be used for increasing the cumulant of adriamycin (DOX) in cells to promote adriamycin to enter into nucleus so as to remarkably promote early apoptosis of an MCF-7/ADR cell (human breast cancer-adriamycin-resistant cells). The 24-acetyl alisol F has an important medical development value in preparing anti-tumor drugs. Due to the action of the 24-acetyl alisol F, the composition prepared from the 24-acetyl alisol F and adriamycin can be used for effectively increasing the sensitivity of the anticancer drug adriamycin and further reducing the side effects of existing chemotherapeutical drugs while improving the chemotherapeutical effect.

The invention belongs to the technical field of formula nourishment and discloses nourishment with a cancer patient chemoradiotherapy auxiliary rehabilitation effect. The nourishment comprises the following raw materials in parts by weight: 20-40 parts of broccoli seed extract, 10-25 parts of fish oil powder, 10-20 parts of Borojo powder, 10-20 parts of yeast beta glucan, 5-10 parts of vitamin C, 5-10 parts of lutein ester powder, 5-10 parts of ginseng powder, 5-10 parts of wheat oligopeptide, 5-10 parts of cordyceps militaris, 5-10 parts of tea leaf theanine and 5-10 parts of bamboo leaf flavone. According to the invention, the broccoli seed extract, the fish oil powder, the Borojo powder, the ginseng powder and the yeast beta glucan which have the cancer auxiliary rehabilitation effect are adopted, so that the postoperative effect of cancer patients is improved, and meanwhile, the side effects of chemoradiotherapy can be reduced; and the lutein ester powder, vitamin C, wheat oligopeptide, bamboo leaf flavone and cordyceps militaris can also promote the functions of the broccoli seed extract, fish oil powder, Borojo powder and ginseng powder, so that all the natural substances play a role in coordination, and further, radiotherapy and chemotherapy side effects of cancer patients can be effectively assisted in treatment.

The embodiment of the invention discloses a traditional Chinese medicine composition for preventing relapse and metastasis of lung cancer. The composition is prepared from the following raw materialsin parts by weight: 6-10 parts of fritillaria cirrhosa, 20-30 parts of oldenlandia diffusa, 30-40 parts of lily, 20-30 parts of sculellaria barbata, 60-80 parts of roasted coix seeds, 24-36 parts of rhodiola rosea, 15-24 parts of coke medicated leaven, 12-24 parts of platycodon grandiflorum, 50-60 parts of rhizoma fagopyri dibotryis, 50-60 parts of liquor processed rhizoma polygonati, 30-40 partsof honey-processed cortex mori radicis, 30-40 parts of exocarpium, 15-18 parts of rhizoma pinelliae preparata, 20-40 parts of thunberg Fritillary Bulb, 40-60 parts of cordyceps militaris, 30-40 partsof poria cocos and 12-24 parts of Chinese wolfberry fruits. The traditional Chinese medicine composition can be used for regulating dynamic balance of a body by adopting raw materials with different medicinal propertyies and reasonable combination according to disease characteristics and traditional Chinese medicine treatment principle, the body immunity can be enhanced, the chemotherapeutic effect can be reinforced, averse response of chemotherapy can be reduced, relapse and metastasis of lung cancer can be effectively reduced to achieve the aims of relieving symptoms, improving living quality and prolonging lives.

The invention discloses replication protein A targeted platinum compound. Tetravalent cis-platinum is combined with an RPA (replication protein A) small-molecule inhibitor through an axial hydroxyl position, and an aliphatic hydrocarbon chain is introduced, and therefore, a series of platinum anti-tumor compounds can be synthesized. The platinum anti-tumor compounds have the advantages of inhibiting the activity and tumor specificity selection of the RPA, so that the platinum anti-tumor compounds show the anti-tumor activity superior to that of a classic platinum drug, and shows the potentialof overcoming the drug resistance of a clinical platinum drug.

The invention relates to a multi-arm PEGylated (Polyethylene Glycolylated) azithromycin derivative and the preparation thereof. By utilizing the characteristic that the multi-arm PEG is non-toxic andeasy to bind, four-arm PEG, six-arm PEG and multi-arm PEG are all connected with DOX. The multi-arm PEG supported DOX prodrug has excellent water solubility. The most important characteristic is thatone multi-arm PEG chain can be connected with multiple DOX residues, and the drug loading rate is greatly improved. Moreover, the half-life of the drug is greatly prolonged, so that lifetime of the drug in plasma is obviously increased, and the curative effects are improved.