30results about How to "Improve chemotherapy efficacy" patented technology

The present invention provides an application of curcumin in preparation of tumor multi-drug drug-resistance preventing preparation. Its CAS mumber is 458-37-7, molecular weight is 368.37, chemical name is 1,7-bis-(4-hydroxy- 3-methoxyphenyl)-1,6-heptadiene-3,5-dione and its molecular formula is C21H2006. The curcumin drug prepared by said invention includes preparation allowable drug excipient and carrier.

The invention discloses an HIFU (high intensity focused ultrasound) controlled-release targeted nanometer drug delivery system of brain glioma, and a preparation method and application of the targeted nanometer drug delivery system. The drug delivery system comprises targeting molecules, a drug, a foaming agent and a nano-carrier, wherein the targeting molecules are Angiopep-2 short-peptide, the drug is adriamycin, the foaming agent is perfluorooctane, and the nano-carrier is a high molecular material which is modified by terminal carboxyl and has polylactic acid-glycolic acid copolymer as a main ingredient; the drug and the foaming agent are wrapped and loaded in the nano-carrier together in a wrapping manner; and the targeting molecules are connected to nano-particle surfaces through a covalent linkage manner. The drug delivery system disclosed by the invention can target and highly express the blood brain barrier of an LRP (low-densitylipoprotein receptor-related protein) receptor and brain glioma cells; the accumulation of the drug at a brain glioma position is effectively improved; after the drug is fully accumulated, HIFU irradiation is given to induce the drug to be instantly and fully released at the brain glioma position; the drug concentration in the brain glioma cells is greatly improved; therefore, the treatment effect of the brain glioma is obviously improved; and meanwhile, the toxic and side effect of the drug on normal tissue is effectively reduced.

The invention discloses a titanium oxide nanometer composite material. The titanium oxide nanometer composite material is characterized by comprising titanium oxide nanometer bubbles; the kernels of the titanium oxide nanometer bubbles are gas; the average grain size of the titanium oxide nanometer bubbles is 10-200 nm. The titanium oxide nanometer composite material can achieve multi-modal imaging, and synergic treatment of malignant tumor is achieved through a sensibilization effect of sonodynamic / photodynamic / optical heat and ultrasonic cavitation on chemotherapeutic drugs.

The invention relates to an amphiphilic targeting functional material based on high expression of tumor amino acid transporter ATB<0, +> and an application of nano preparation modified by the same in targeting therapy of tumor. In the amphiphilic targeting functional material, stearic acid (SA) serves as a hydrophobic end while amino acid (AA) serves as a target end, and the middle connection bridge is polyethylene glycol (PEG). The nano preparation modified by the amphiphilic targeting functional material can remarkably improve the tumor targeting ability of an active drug. The characteristics of the invention are that the targeting functional material is easy to prepare, and the nano preparation modified by the targeting functional material can actively target the amino acid transporter ATB<0, +> with high expression of tumor, has high biocompatibility and can remarkably improve the drug therapeutic effect.

The invention provides a compounding method for novel functional milk, which belongs to a preparation method for the milk powder which contains various effective active compositions and is processed according to the industry law. Cancer is a consumptive disease and radiotherapy and chemotherapy cause certain gastrointestinal reaction (surfeit, vomit, anorexia, intestinal malabsorption, etc.), which causes insufficiency of nutrition intake of the patient and low nutrition state; therefore, supplementing reasonable nutrition is beneficial to the disease curing. According to the weight portions, the product of the invention comprises the compositions as follows: 65.5 portions of fresh milk, 10.6 portions of skimmed milk powder, 2.8 portions of vegetable oil, 0.2 portions of lentinan, 0.4 portions of pachyman, 0.05 portions of selenide carrageenan and 10 portions of whey powder. The product of the invention is a functional edible milk powder.

The invention provides a dissoluble microneedle carrying lipidosome cis-platinum nano-particles and a preparation method of the dissoluble microneedle. Through a reverse micro-emulsion method, a cis-platinum precursor higher in solubility is prepared, and the lipidosome nano-particles are prepared; multiple kinds of lipidosome wrap cis-platinum, targeted location of cancer cells is achieved, the nano-particles directly act on the cancer cells, the nano-particles are carried on a dissoluble microneedle, and the dissoluble microneedle is directly pasted on tumors exposed to the epidermis to improve the curative effect of chemotherapeutic drugs and reduce side effects. According to the lipidosome nano-particles prepared through the method, the solubility of cis-platinum is improved, the lipidosome nano-particles can be applied to various drugs hard to dissolve in water, and convenience is provided for manufacturing of the dissoluble microneedle. By means of the lipidosome nano-particles,the drug toxicity of the chemotherapeutic drugs on the cancer cells can be improved, and the side effects are reduced to a certain degree. The chemotherapeutic drugs are wrapped by the microneedle, local painless injection can be achieved, the anticancer effect is remarkably improved, and the side effects are reduced.

The invention provides an adriamycin and gene medicine co-transporting nano medicine carrying system and a preparation method. The co-transporting nano medicine carrying system is TPGS modified cationic liposome for co-carrying adriamycin and gene medicine, wherein a membrane material of the cationic liposome is prepared from 1,2-dioleoyl-3-trimethylammonio-propane or chlorate of the 1,2-dioleoyl-3-trimethylammonio-propane, dipalmitoyl phosphatidylcholine, TPGS and cholesterol. The prepared co-transporting nano medicine carrying system disclosed by the invention has a higher adriamycin encapsulating efficiency, stability of the co-transporting nano liposome is improved; meanwhile, complete inhibition on a tumor cell efflux pump can be achieved by only adjusting a formula, the purposes of two drug resistance mechanisms of inhibiting tumor medicine efflux and resisting apopotosis are achieved at the same time, and tumor multidrug resistance can be more completely and more effectively reversed.

The invention discloses a thioketal bond connected pegylated Ce6 material as well as a preparation method and application thereof. The method comprises the following steps: saturating a mixture of cysteamine hydrochloride and acetone with hydrogen chloride, and performing reaction to obtain diamine containing thioketal bonds; performing reaction on methoxy polyethylene glycol carboxyl, dicyclohexylcarbodiimide and N-hydroxysuccinimide, and dropwise adding a polyethylene glycol solution into a diamine solution containing thioketal for reaction to obtain mPEG-TK-NH2; dissolving chlorin e6, dicyclohexylcarbodiimide and N-hydroxysuccinimide in a solvent for reaction; and adding the activated Ce6 solution into the mPEG-TK-NH2 solution, and carrying out a stirring reaction to obtain the thioketal bond connected pegylated Ce6 material. The thioketal bond connected pegylated Ce6 material has biocompatibility and degradability, and can enhance the uptake of drug-loaded particles by cells, so that the drug concentration in the cells is improved, tumor cells are killed, and the chemotherapy effect is improved.

The invention relates to a pharmaceutical composition for treating the cancer and an application of the pharmaceutical composition. The pharmaceutical composition comprises methotrexate as an active ingredient and a BRD4 protein inhibitor, and the mass ratio of the methotrexate to the BRD4 protein inhibitor ranges from 10:1 to 1:8. The pharmaceutical composition obviously improves the chemotherapeutic effect of the methotrexate, the similar chemotherapeutic effect is achieved by using the methotrexate at the relatively low concentration, therefore, the toxicity on a nude mouth is obviously reduced, and the injury of the pharmaceutical composition on the organism is reduced, so that the pharmaceutical composition is applied to preparation of anti-tumor drugs.

The present invention provides a breast cancer conditioning convenience food, which uses L- glutamine as the main raw material, is based on the physical characteristics of breast cancer patients, is directed by essence of traditional Chinese medicine theory and has targeted reasonable compatibility: extract of dendrobium, semen coicis, oysters, dandelion, hawthorn, fructus perillae, honeysuckle flower, dates, tangerine red epicarp, longan, date seed, cinnamon, licorice, winter collybia, dried tangerine peel, Poria, siberian solomonseal rhizome, ginseng, gardenia, common selfheal spike, peppermint, appendiculate cremastra pseudobulb and other medicinal and edible herbs. Then vitamins and minerals are added to obtain the food. The food produced according to the formula in the present invention is easy to dissolve, fast to absorb and utilize, and improves the nutritional status of the breast cancer patients. The bioactive components in the medicinal and edible herb extract have assistance effects of improving immunity of human body, thereby playing a role of suppressing cancer and anti-cancer. The food is suitable for breast cancer patients, especially for the cancer patients received radiotherapy or chemotherapy to eat. Therefore, the food has unique advantages of combining triple effects of diet cure, prevention and conditioning.

The invention provides a design and preparation method for a multiple-response type nanodrug based on combined treatment. The design and preparation method comprises the following steps of: through graphene oxide, loading adriamycin and indocyanine green, then, coating the graphene oxide with gelatin, obtaining nanometer particles with an even size through a secondary emulsification method, and finally, carrying out crosslinking through N, N'-bis (acrylyl) cystamine to obtain the multiple-response type nanodrug. The design and preparation method adopts the gelatin as a nanoparticle shell, biocompatibility is improved, in addition, the multiple-response type nanodrug has size conversion capability, a penetration effect of the nanodrug on a tumor position is improved, the combined treatmentcan be realized through the graphene oxide, the adriamycin and the indocyanine green, and an anti-tumor effect is obviously improved.

The invention relates to a multifunctional polyethylene glycol-dual vitamin E succinate derivative and application thereof in drug delivery. An amphiphilic block copolymer utilizes polyethylene glycol as a hydrophyllic end to be combined with bimolecular hydrophobic vitamin E succinate under bridging of lysine, so that the AB2 type two-arm amphiphilic block copolymer is obtained. The polymer has potential antineoplastic activity and P-gp inhibitory action, and is capable of synergetically and effectively overcoming multidrug resistance to increase chemotherapeutic effect. Besides, the block copolymer can be self-assembled to form a micelle in aqueous medium, and can serve as a reservoir of poorly water-soluble drug, protein and gene-based drug, and the micelle is safe and high in stability and encapsulation, can be used for intravenous injection and oral ingestion, and has bright market application prospects.

The invention relates to a traditional Chinese medicine for treating breast cancer and a preparation method thereof. The traditional Chinese medicine for treating breast cancer is prepared from the following raw materials in parts by weight: dried green peel of Juglans mandshurica Maxim., gromwell, curcuma root, raidx astragali, white atractylodes rhizome, polyporus umbellatus, subprostrate sophora root and bezoar. The traditional Chinese medicine for treating breast cancer has the functions of clearing away heat and toxic material, strengthening the body resistance, regulating the flow of qi and eliminating blood stasis, can directly injure and destroy the membrane system of cancer cells to induce cancer cell lysis and collapse, can induce the cancer cells to generate a big amount of lysosome to suicidally destroy the cancer cells, can activate lymphocytosis and improve the body cellular immune function, can promote stellate cells of liver to have active functions to inhibit and kill the cancer cells by the immune system, and has good curative effects and high effective rate on treating breast cancer without toxic side effects.

The present invention discloses a Chinese medicine for curing laryngocarcinoma. Said Chinese medicine is made up by using 18 Chinese medicinal material of pseudostellaria root, codonopsis root, dendrobium stem, adenophoral glehnia root, ophiopogon tuber and others through a certain preparation process.

The invention provides an adriamycin and gene medicine co-transporting nano medicine carrying system and a preparation method. The co-transporting nano medicine carrying system is TPGS modified cationic liposome for co-carrying adriamycin and gene medicine, wherein a membrane material of the cationic liposome is prepared from 1,2-dioleoyl-3-trimethylammonio-propane or chlorate of the 1,2-dioleoyl-3-trimethylammonio-propane, dipalmitoyl phosphatidylcholine, TPGS and cholesterol. The prepared co-transporting nano medicine carrying system disclosed by the invention has a higher adriamycin encapsulating efficiency, stability of the co-transporting nano liposome is improved; meanwhile, complete inhibition on a tumor cell efflux pump can be achieved by only adjusting a formula, the purposes of two drug resistance mechanisms of inhibiting tumor medicine efflux and resisting apopotosis are achieved at the same time, and tumor multidrug resistance can be more completely and more effectively reversed.

The invention discloses a method for entrapment of a chemotherapeutic drug by using autologous organoid derived microbubbles of a tumor patient and application of the chemotherapeutic drug. The method comprises the following steps: (1) shearing autologous tumor tissues of a tumor patient, then carrying out enzyme digestion, then filtering digested tumor cells by using a filter screen, carrying out centrifugal collection, then uniformly mixing with matrigel, then adding an organoid culture medium for culturing, and collecting to obtain an organoid when the diameter of the organoid is 200-400 [mu] m; (2) performing ultraviolet stimulation on the organoid, adding a chemotherapeutic drug, incubating, collecting a culture solution, centrifuging to remove cells and fragments, and centrifuging and collecting to obtain drug-loaded organoid microbubbles; wherein the ultraviolet stimulation condition is that an ultraviolet lamp with the power being 8 W and the wavelength being 254 nm is used for irradiating for 30-90 min. The drug-loaded organoid microbubble constructed in the invention has a tumor targeting effect and a stronger tumor cell killing effect, and can be used for treating tumors.

The invention provides novel use of 24-acetyl alisol F (ALI). The 24-acetyl alisol F can be used for increasing the cumulant of adriamycin (DOX) in cells to promote adriamycin to enter into nucleus so as to remarkably promote early apoptosis of an MCF-7 / ADR cell (human breast cancer-adriamycin-resistant cells). The 24-acetyl alisol F has an important medical development value in preparing anti-tumor drugs. Due to the action of the 24-acetyl alisol F, the composition prepared from the 24-acetyl alisol F and adriamycin can be used for effectively increasing the sensitivity of the anticancer drug adriamycin and further reducing the side effects of existing chemotherapeutical drugs while improving the chemotherapeutical effect.

The invention belongs to the field of antitumor drugs, and discloses preparation and an application of a dual-curative-effect antitumor drug based on nanocellulose loaded nanogold and curcumin. According to the drug carrier disclosed by the invention, nano-crystalline cellulose is selected and is properly treated, nano-gold particles and cyclodextrin are loaded on the carrier, and an anti-tumor drug is accommodated in the cyclodextrin. The problem that an existing natural anti-tumor drug is difficult to dissolve is solved. The AuNP loaded on the nanoparticles realizes a thermal therapy effect under near-infrared irradiation, and the thermal effect can promote heat release of curcumin, so that the efficacy of chemotherapy is enhanced. The heat resistance and stability of the anti-tumor drug curcumin are remarkably improved, pretreatment is facilitated, and the bioavailability of the curcumin can be improved. The water solubility of the curcumin is remarkably improved, is improved by about 150 times compared with the natural solubility of the curcumin, and reaches 131.7 [mu]g / mL. It is predicted that the anti-tumor drug with the double curative effects will become a powerful candidate drug for tumor treatment.

The invention belongs to the technical field of formula nourishment and discloses nourishment with a cancer patient chemoradiotherapy auxiliary rehabilitation effect. The nourishment comprises the following raw materials in parts by weight: 20-40 parts of broccoli seed extract, 10-25 parts of fish oil powder, 10-20 parts of Borojo powder, 10-20 parts of yeast beta glucan, 5-10 parts of vitamin C, 5-10 parts of lutein ester powder, 5-10 parts of ginseng powder, 5-10 parts of wheat oligopeptide, 5-10 parts of cordyceps militaris, 5-10 parts of tea leaf theanine and 5-10 parts of bamboo leaf flavone. According to the invention, the broccoli seed extract, the fish oil powder, the Borojo powder, the ginseng powder and the yeast beta glucan which have the cancer auxiliary rehabilitation effect are adopted, so that the postoperative effect of cancer patients is improved, and meanwhile, the side effects of chemoradiotherapy can be reduced; and the lutein ester powder, vitamin C, wheat oligopeptide, bamboo leaf flavone and cordyceps militaris can also promote the functions of the broccoli seed extract, fish oil powder, Borojo powder and ginseng powder, so that all the natural substances play a role in coordination, and further, radiotherapy and chemotherapy side effects of cancer patients can be effectively assisted in treatment.

The invention relates to a doxorubicin pegylated epothilone B and a preparation method thereof. The method mainly includes the following steps: 1) reacting doxorubicin and hydrazide polyethylene glycol carboxyl under the action of phosphoric acid to prepare Doxorubicin polyethylene glycol carboxyl intermediate, wherein the molar ratio of doxorubicin to phosphoric acid is 1:0.01-0.02; 2) under the action of the second coupling agent and catalyst, epothilone B and doxorubicin Polyethylene glycol carboxyl intermediate reacts to obtain doxorubicin pegylated epothilone B conjugate.

The invention discloses a preparation method of I MB16-4 lipidosome nanoparticles and a medicine, and belongs to the technical field of pharmaceutical preparations, the preparation method comprises the following steps: dissolving I MB16-4 in a first organic solvent, then adding into a first solution of polyvinylpyrrolidone, and stirring to obtain a first nano suspension; after the first nano suspension is centrifuged, sediment is taken; adding a second solution of polyvinylpyrrolidone into the precipitate, and dispersing to obtain a second nano suspension; adding the second nano suspension into a lipid membrane to obtain a third nano suspension; hydrating the third nano suspension, and performing ultrasonic treatment to obtain a fourth nano suspension; and adding a freeze-drying protective additive into the fourth nano suspension, and carrying out freeze-drying, so as to obtain I MB16-4 liposome nanoparticle freeze-dried powder. The I MB16-4 is prepared into the liposome nanoparticles, so that the solubility and the absorption amount of the I MB16-4 are improved, the generation of MMP2, alpha-SMA and TGF-beta in liver cells is reduced, the anti-hepatic fibrosis curative effect is improved, and the toxic and side effects are reduced.

The embodiment of the invention discloses a traditional Chinese medicine composition for preventing relapse and metastasis of lung cancer. The composition is prepared from the following raw materialsin parts by weight: 6-10 parts of fritillaria cirrhosa, 20-30 parts of oldenlandia diffusa, 30-40 parts of lily, 20-30 parts of sculellaria barbata, 60-80 parts of roasted coix seeds, 24-36 parts of rhodiola rosea, 15-24 parts of coke medicated leaven, 12-24 parts of platycodon grandiflorum, 50-60 parts of rhizoma fagopyri dibotryis, 50-60 parts of liquor processed rhizoma polygonati, 30-40 partsof honey-processed cortex mori radicis, 30-40 parts of exocarpium, 15-18 parts of rhizoma pinelliae preparata, 20-40 parts of thunberg Fritillary Bulb, 40-60 parts of cordyceps militaris, 30-40 partsof poria cocos and 12-24 parts of Chinese wolfberry fruits. The traditional Chinese medicine composition can be used for regulating dynamic balance of a body by adopting raw materials with different medicinal propertyies and reasonable combination according to disease characteristics and traditional Chinese medicine treatment principle, the body immunity can be enhanced, the chemotherapeutic effect can be reinforced, averse response of chemotherapy can be reduced, relapse and metastasis of lung cancer can be effectively reduced to achieve the aims of relieving symptoms, improving living quality and prolonging lives.

The invention discloses replication protein A targeted platinum compound. Tetravalent cis-platinum is combined with an RPA (replication protein A) small-molecule inhibitor through an axial hydroxyl position, and an aliphatic hydrocarbon chain is introduced, and therefore, a series of platinum anti-tumor compounds can be synthesized. The platinum anti-tumor compounds have the advantages of inhibiting the activity and tumor specificity selection of the RPA, so that the platinum anti-tumor compounds show the anti-tumor activity superior to that of a classic platinum drug, and shows the potentialof overcoming the drug resistance of a clinical platinum drug.

The invention relates to a multi-arm PEGylated (Polyethylene Glycolylated) azithromycin derivative and the preparation thereof. By utilizing the characteristic that the multi-arm PEG is non-toxic andeasy to bind, four-arm PEG, six-arm PEG and multi-arm PEG are all connected with DOX. The multi-arm PEG supported DOX prodrug has excellent water solubility. The most important characteristic is thatone multi-arm PEG chain can be connected with multiple DOX residues, and the drug loading rate is greatly improved. Moreover, the half-life of the drug is greatly prolonged, so that lifetime of the drug in plasma is obviously increased, and the curative effects are improved.

The invention provides novel use of 24-acetyl alisol F (ALI). The 24-acetyl alisol F can be used for increasing the cumulant of adriamycin (DOX) in cells to promote adriamycin to enter into nucleus so as to remarkably promote early apoptosis of an MCF-7 / ADR cell (human breast cancer-adriamycin-resistant cells). The 24-acetyl alisol F has an important medical development value in preparing anti-tumor drugs. Due to the action of the 24-acetyl alisol F, the composition prepared from the 24-acetyl alisol F and adriamycin can be used for effectively increasing the sensitivity of the anticancer drug adriamycin and further reducing the side effects of existing chemotherapeutical drugs while improving the chemotherapeutical effect.

The invention provides a gene medicine for promoting the differentiation of tumor stem cells. The gene medicine comprises a recombinant of which the target gene is a Nell-1 gene and can effectively induce the differentiation of the tumor stem cells, inhibit the multiplication of tumor cells, reduce the drug resistance of the tumor cells and improve the drug sensitivity and can be combined with chemical treatment to enhance the chemical treatment effect; and the gene medicine is low in toxic and side effects and safely used. A carrier of the recombinant can be an expression plasmid or a virus carrier, preferably the virus carrier; the virus carrier is preferably selected from one of an adenovirus carrier, a herpes simplex virus carrier, a retroviruse carrier, an adeno associated virus carrier and a slow virus carrier; and most preferably, the virus carrier is the adenovirus carrier.