Dissoluble microneedle carrying lipidosome cis-platinum nano-particles and preparation method of dissoluble microneedle

A nanoparticle and liposome technology, applied in the field of biomedicine, to achieve strong drug toxicity, prolong action time, and reduce systemic side effects

Inactive Publication Date: 2018-09-04
苏宇雄 +2
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, in the field of tumor treatment, the application of microneedles is still blank.

Method used

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  • Dissoluble microneedle carrying lipidosome cis-platinum nano-particles and preparation method of dissoluble microneedle
  • Dissoluble microneedle carrying lipidosome cis-platinum nano-particles and preparation method of dissoluble microneedle
  • Dissoluble microneedle carrying lipidosome cis-platinum nano-particles and preparation method of dissoluble microneedle

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[0025] A method for preparing a dissolvable microneedle loaded with liposomal cisplatin nanoparticles, comprising the steps of:

[0026] Step A, preparation of nanoparticles: dissolving cisplatin in water, adding an equivalent amount of silver nitrate, heating and stirring, centrifuging to remove silver chloride particles, and the obtained liquid is the cisplatin precursor; the cisplatin precursor is mixed with 1, 2-dioleoyl-sn-glycerol-3-phosphate (DOPA) dissolved in cyclohexane and In the oil phase A composed of CO-520, potassium chloride was dissolved in cyclohexane, Triton TM In the oil phase B of X-100 and n-hexanol, mix and stir the solution composed of oil phase A and oil phase B, centrifuge at high speed to obtain nanoparticles, dissolve the nanoparticles in chloroform, and add an appropriate amount of liposomes, such as: 1, 2-dioleoyl-3-trimethy-lammonium-propane(DOTAP), 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000](ammonium sa...

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Abstract

The invention provides a dissoluble microneedle carrying lipidosome cis-platinum nano-particles and a preparation method of the dissoluble microneedle. Through a reverse micro-emulsion method, a cis-platinum precursor higher in solubility is prepared, and the lipidosome nano-particles are prepared; multiple kinds of lipidosome wrap cis-platinum, targeted location of cancer cells is achieved, the nano-particles directly act on the cancer cells, the nano-particles are carried on a dissoluble microneedle, and the dissoluble microneedle is directly pasted on tumors exposed to the epidermis to improve the curative effect of chemotherapeutic drugs and reduce side effects. According to the lipidosome nano-particles prepared through the method, the solubility of cis-platinum is improved, the lipidosome nano-particles can be applied to various drugs hard to dissolve in water, and convenience is provided for manufacturing of the dissoluble microneedle. By means of the lipidosome nano-particles,the drug toxicity of the chemotherapeutic drugs on the cancer cells can be improved, and the side effects are reduced to a certain degree. The chemotherapeutic drugs are wrapped by the microneedle, local painless injection can be achieved, the anticancer effect is remarkably improved, and the side effects are reduced.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, in particular to a dissolvable microneedle loaded with liposome cisplatin nanoparticles. Background technique [0002] Microneedles are three-dimensional arrays made of silicon, metal, and polymers with a length of 25-2000 μm and tapered needle tips. Microneedle is a new type of minimally invasive drug delivery tool in the field of biomedicine, which can enhance the drug delivery effect of the skin through the epidermis and dermis of the skin. Microneedles have been widely used in the field of transdermal drug delivery due to their advantages of high efficiency, safety, and painlessness. However, in the field of tumor treatment, the application of microneedles is still blank. Contents of the invention [0003] This patent prepares soluble microneedles by using cellulose and chemotherapeutic drugs, and the microneedles can directly act on the tumor site to improve the toxicity of chemother...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K33/24A61K9/127A61K47/38A61P35/00A61M37/00
CPCA61K9/0021A61K9/127A61K33/24A61K47/38A61M37/0015A61M2037/0053A61P35/00
Inventor 苏宇雄谢曦兰新苗
Owner 苏宇雄
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