Double-curative-effect antitumor drug based on nano-cellulose loading and preparation method of double-curative-effect antitumor drug

Abstract

The invention belongs to the field of antitumor drugs, and discloses preparation and an application of a dual-curative-effect antitumor drug based on nanocellulose loaded nanogold and curcumin. According to the drug carrier disclosed by the invention, nano-crystalline cellulose is selected and is properly treated, nano-gold particles and cyclodextrin are loaded on the carrier, and an anti-tumor drug is accommodated in the cyclodextrin. The problem that an existing natural anti-tumor drug is difficult to dissolve is solved. The AuNP loaded on the nanoparticles realizes a thermal therapy effect under near-infrared irradiation, and the thermal effect can promote heat release of curcumin, so that the efficacy of chemotherapy is enhanced. The heat resistance and stability of the anti-tumor drug curcumin are remarkably improved, pretreatment is facilitated, and the bioavailability of the curcumin can be improved. The water solubility of the curcumin is remarkably improved, is improved by about 150 times compared with the natural solubility of the curcumin, and reaches 131.7 [mu]g / mL. It is predicted that the anti-tumor drug with the double curative effects will become a powerful candidate drug for tumor treatment.

Description

technical field [0001] The invention belongs to the field of antitumor drugs, in particular to a nanocellulose carrier-based antitumor drug with dual efficacy and a preparation method thereof. Background technique [0002] Tumor is one of the major diseases that endanger human health. With higher requirements for therapeutic effects, treatment procedures, side effects, etc., drugs with multiple therapeutic effects and natural anti-tumor drugs are increasingly favored by patients and researchers. However, many natural antitumor drugs are insoluble in water, which greatly limits the application of such drugs. Taking curcumin as an example, curcumin has a good inhibitory effect on the formation, proliferation and metastasis of tumor cells. Curcumin is gaining more and more attention from researchers due to its low cost, wide range of sources and various medicinal properties. However, due to curcumin's poor solubility, low loading capacity, and weak release ability, resulting...

AI Technical Summary

Problems solved by technology

However, these preparations are often complex in structure, which is not conducive to production and transportation

For example, microcapsules, liposomes and multi-layer core-shell structures, leaking drugs may cover the gold nanoparticles, and cannot be heated up to release the encapsulated drugs under light, thus losing the dual efficacy

[0005] Therefore, there is still a need to improve the water solubility and release ability of antineoplastic drugs to enhance the effect of chemotherapy, and there are still challenges in making antineoplastic drugs have dual curative effects of chemotherapy and physical therapy

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