41results about How to "Reduce chemotherapy side effects" patented technology

The invention discloses a titanium oxide nanometer composite material. The titanium oxide nanometer composite material is characterized by comprising titanium oxide nanometer bubbles; the kernels of the titanium oxide nanometer bubbles are gas; the average grain size of the titanium oxide nanometer bubbles is 10-200 nm. The titanium oxide nanometer composite material can achieve multi-modal imaging, and synergic treatment of malignant tumor is achieved through a sensibilization effect of sonodynamic / photodynamic / optical heat and ultrasonic cavitation on chemotherapeutic drugs.

The invention provides a drug for treating malignant pleural effusion with Qi and Yin deficiency, comprising materials: Radix Codonopsis, Radix Acanthopanacis Semticosi, Radix Scrophulariae, Semen Plantaginis, Semen Lepidii, Herba Ephedrae, Ramulus Cinnamomi, Radix et Rhizoma Rhei, Cortex Mori, Rhizoma Dioscoreae, Herba Orchidis Latifoliae, Radix Morinaceae, Radix Araliae, Radix Asparagi, Flos lonicerae, Herba Cymbopogonis, Herba seu Radix Asteris Ageratozdis, and pollen typhae. An effective means to treat malignant pleural effusion is given using the drug with chemotherapy through pleural perfusions, thus recurrence rate of pleural effusion of lung cancer is decreased and curative effect is improved, toxic and side effects of chemotherapy can also be relieved and the curative effect can also be enhanced, by using traditional Chinese medicine, and meanwhile, life quality of a patient is improved and clinical symptoms are relieved, both the entirety and locality of the patient are cared and the purpose of strengthening body resistance and eliminating evil is achieved.

The invention provides a medicine for treating malignant pleural effusion with syndrome of phlegm-dampness due to spleen deficiency. The medicine consists of the following medicinal raw materials: rheum officinale, semen lepidii, radix curcumae, cassia twig, bigflower cape jasmine fruit, pseudobulbus cremastrae seu pleiones, selfheal, codonopsis pilosula, dried ginger, schisandra chinensis, hemarthria sibirica, oriental dodartia herb, platycodon grandiflorum, radix angelicae pubescentis, herba ephedra, radix liriopes, fructus arctii, bighead atractylodes rhizome, radix scrophulariae, rhizoma acori graminei and liquorice root. The medicine, in combination with pleural infusion chemotherapy, provides an effective means for treating malignant pleural effusion, so as to relieve the reoccurrence speed of lung cancer with pleural effusion and to enhance a curative effect; in addition, in combination with traditional Chinese medicines, the medicine can relieve toxic and side effects caused by the chemotherapy and consolidate the curative effect; and meanwhile, the medicine can improve life quality and relieve clinical symptoms of a patient, and can give consideration to both the whole and the part of the patient, so as to achieve purposes of strengthening body resistance and eliminating evil.

The invention discloses application of AZA (Anchoic Acid) in preparation of acute myelogenous leukemia (AML) resistant and chemosensitization drugs. Through demonstration, AZA has a killing effect on multiple AML cell strains (U937, THP-1, KG-1, NB4, and HL-60), and can be used for inhibiting the proliferation of AML cells and simultaneously inducing cell apoptosis, and can be combined with Arac in use to promote the killing effect of Arac on the AML cells. AZA does not have any toxic and side effects, and the price can be accepted by most patients; and AZA can be combined with chemotherapeutics, namely Arac in use to promote the killing effect of Arac on the AML cells, and also to reduce the dosage of Arac to alleviate the toxic and side effects caused by chemotherapy, so that a new approach and method is provided for treatment and curing of the AML.

The invention relates to a Chinese materia medica preparation, in particular to a traditional Chinese composition of Beiqi lung supplement tablet used for phithis, which is particularly applicable to Qiyin damage symptoms of secondary tuberculosis of lung. The traditional Chinese composition is prepared by the materials of the following weight portions: 120 to 180 portions of milk veteh, 60 to 90 portions of lily roots, 60 to 90 portions of ophiopogon roots, 45 to 75 portions of fritillary bulb, 90 to 135 portions of ordate houttuynia, 90 to 135 portions of Radix picrorrhizae, 75 to 110 portions of ternate buttercup roots, 90 to 135 portions of stemona, 60 to 90 portions of balloon flower, 30 to 45 portions of Panaxnotoginseng, and 60 to 90 portions of Bletilla striata. The traditional Chinese composition has the effects of supplementing qi and nourishing yin, moistening the lung and relieving the cough, and growing muscles and stanching bleeding, can rapidly relieve tuberculosis symptoms, has relatively ideal effects in the major aspects of preventing cough, eliminating phlegm, stanching bleeding, resisting inflammation, regulating immune and the like, and can reduce side-effects of chemo-treatment, facilitate sputum negative conversion, focus absorption and pore closure. The side-effects are small and the medical healing effects are reliable; moreover, the traditional Chinese composition is worthy of being popularized and applied.

The invention discloses a new application of small-molecular citrus pectin. The small-molecular citrus pectin can be used for preparing anti-tumor auxiliary medicines which have immunoregulation effects and can be used for cooperating with the effect-enhancing and toxicity-reducing action of chemotherapy medicines, or can be used for preparing health products with anti-tumor auxiliary effects. A compound disclosed by the invention cannot be used for directly killing tumor cells when being separately used, and does not have anti-tumor effects; the compound can be taken as an auxiliary medicine, can cooperate with the chemotherapy medicines for use, can have immunoregulation functions on T cells and MDSC cells by virtue of ligands on the surfaces of antagonistic immune cells and tumor tissue cells of the compound, can be used for enhancing the anti-tumor effects in an auxiliary mode, and ensures that the sensitivity-enhancing and toxicity-reducing effects on tumor chemotherapy can be achieved; and new medical applications of the known compound namely the small-molecular citrus pectin can be explored, and a new application field can be created.

The invention discloses an anti-tumor drug and application of isoniazid in preparation of the anti-tumor drug, and belongs to the technical field of biomedicine. According to the application of the isoniazid in preparation of the anti-tumor drug, the anti-tumor drug is a compound preparation of a chemotherapy drug and an enhancer thereof, and the isoniazid is used as the enhancer of the chemotherapy drug. The compound preparation clears away a path through promoting oxidation of tumor cells and blocking cell active oxygen, so as to improve the level of the active oxygen in the tumor cells, thereby enhancing the ability of the chemotherapy drug to kill the tumor cells. According to the anti-tumor drug and the application of the isoniazid in preparation of the anti-tumor drug, the usage amount of the anti-tumor chemotherapy drug is effectively reduced under the same curative effect, the inhibitory effect on the tumor cells is stronger and selectivity is realized, that is, normal cells are less damaged, and the toxic and side effects of doxorubicin are effectively reduced; a safer and more effective chemotherapy drug administration method is provided; a relatively high popularizationvalue is realized.

The invention provides a stomach-strengthening medicinal and edible composition for assisting in treatment of advanced digestive tract cancer. The composition is prepared from the following raw materials by weight of 500 g of rhizoma dioscoreae, 500 g of semen nelumbinis, 500 g of semen euryales, 500 g of yellow millet and 500 g of semen coicis. According to the composition, the medicinal and edible traditional Chinese medicinal materials are used as main materials and combined with the nutrient-rich yellow millet, and the composition has good curative effect on the advanced digestive tract cancer as an adjuvant therapy, significantly improves the life quality of patients and reduces the side effects of chemotherapy. The rhizoma dioscoreae, the semen euryales, the semen nelumbinis and the semen coicis are selected as the medicinal and edible traditional Chinese medicinal materials, are rich in nutritional ingredients and functional ingredients, have various pharmacological activities and good health-care functions, and can increase nutrition intake and resist tumors when being used for the patients with digestive tract cancers. The composition has a clinic guiding effect.

The invention discloses a traditional Chinese medicine for treating stomach cancer and a treatment method of the traditional Chinese medicine. The traditional Chinese medicine is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight: 9-13 parts of ginseng, 6-9 parts of atractylodes macrocephala, 6-9 parts of poria cocos, 4-5 parts of radix glycyrrhizae preparata, 15-20 parts of ginger, 10-15 parts of dates, 2-4 parts of sculellaria barbata, 8-10 parts of unprepared trogopterus dung, 20-23 parts of unprepared black morning glory, 9-12 parts of unprepared cyperus rotundus and 11-13 parts of unprepared costus roots. The traditional Chinese medicine disclosed by the invention has remarkable anti-cancer activity, is capable of comprehensively improving the immunity of human bodies of patients, has a relatively high killing and inhibition function on cancer cells, is free of toxic or side effect on human bodies, can intensify the treatment effect, reduce the toxic and side effect of chemotherapy, has a remarkable treatment effect when being used for treating stomach cancer clinically and is free of irritation, does not irritate stomachs with lesion, the medicine effect is greatly improved as oral taking and ironing are combined, and the patients are prevented from stomach pain torment when the medicine is used.

The invention discloses a preparation method of an antrodia extract, and belongs to the technical field of application of edible and medicinal fungi. The method comprises extracting vessel-cultured antrodia sporocarp powder with an ethanol solution and conducting vacuum concentration on a filtrate to obtain a crude extract; adsorbing the crude extract with macroporous resin, placing the mixture ina rectangular container, washing the mixture out with a mixed solution, conducting vacuum concentration on an eluent, drying to obtain a first sub extract of the antrodia contract, then washing out with the ethanol solution, conducting vacuum concentration on the eluent, drying to obtain a second sub extract of the antrodia contract, washing out with an ethyl acetate solution, conducting vacuum concentration on the eluent and drying to obtain a third sub extract of the antrodia contract. The invention also provides a preparation method for an antrodia composition and a pharmaceutical composition. The sub extracts of the antrodia extract or the antrodia composition can be used for treating cancer and reducing side effects of chemotherapy.

The present invention provides a Chinese medicine-Shenhong Quyusanjie capsule preparation for curing cancers. Said capsule preparation is made up by using 16 Chinese medicinal materials of ginseng, saffron, trichosanthes root, astragalus root, longan flesh, corydalis tuber and others. Said invention possesses the functions of boosting qi, promoting blood circulation, removing stasis, stopping pain, clearing away heat and removing toxic material and softening hardness and dissipating binds, so that it is a non-toxic, safe, broad-spectrum and effective anti-cancer medicine, and its total effective rate can be up to 92.3%.

The invention relates to mud snail vermicelli and a production method thereof. The mud snail vermicelli comprises the following raw materials in percentage by weight: 60%-75% of starch, 8%-20% of roquette seed powder, 8%-20% of artemisia desterorum spreng seed powder, 5%-15% of mud snail proteolysis liquid and 1.0%-1.8% of calcium salt. Therefore, a traditional eating method of mud snails is broken through; the characteristic that nutritional components of the mud snail proteolysis liquid are very easy to absorb is utilized sufficiently and the inherent fishy smell of the mud snails is removed; bioactive substances and nutritional health-care components of the starch, roquette seeds, artemisia desterorum spreng seeds and the like are introduced into a vermicelli product sufficiently to generate a synergistic interaction effect, so that the nutrition is comprehensive and abundant, the health-care function is prominent, the taste is delicious, the mouth feel is good, the elasticity and the toughness are good, the mud snail vermicelli is natural and green, and the eating safety is high. After the mud snail vermicelli is eaten usually, the immunocompetence of a human body can be improved, the physiological equilibrium of an organism is kept, the body is built and the life is prolonged. The invention provides a novel green vermicelli food which is nutritional, health-care and purely natural, and has a tender and smooth mouth feel and a delicious taste.

The invention discloses a traditional Chinese medicine compound reducing chemotherapy side reaction. The compound comprises the following components by weight: 5-10 parts of codonopsis pilosula, 5-10 parts of fried bighead atractylodes rhizome, 10-15 parts of poria cocos, 1 part to 3 parts of coptis chinensis, 8-10 parts of perilla stem, 10-30 parts of fructus psoraleae, 10-30 parts of caulis spatholobi, 10-15 parts of rhodiola rosea, 6-10 parts of rhizoma pinellinae praeparata, 3-6 parts of pericarpium citri reticulatae, 10-30 parts of pyrrosia lingua, 5-10 Chinese-date, 6-10 parts of bamboo shavings, 3-6 parts of honey-fried licorice root and 3-6 parts of sea-buckthorn. A preparation method and the application of the traditional Chinese medicine compound are further disclosed. Aiming at the basic pathogenesis of 'spleen-stomach deficiency and qi-blood deficiency' of chemotherapy side reaction, the traditional Chinese medicine compound strengthens the spleen and the stomach, reinforces qi, nourishes blood, reduces chemotherapy side reaction and has exact effects clinically.

The invention discloses a Chinese medicinal preparation for treating pulmonary tuberculosis and a preparation method thereof. The Chinese medicinal preparation is prepared from the following bulk drugs by weight: 70-90 parts of ladybell roots, 50-70 parts of Chinese yam, 30-42 parts of Chinese mahonia leaves, 150-210 parts of wild buckwheat roots, 50-70 parts of Cynanchum atratum, 65-85 parts of Areca Peel, 35-65 parts of Lotus Rhizome Node, 65-95 parts of astragalus, and 50-70 parts of bletilla striata. By compatibility of the drug ingredients and the synergistic complementary effects of the ingredients on pulmonary tuberculosis, a new medication choice is added for treatment of pulmonary tuberculosis disease. Compared with other types of Chinese medicinal compositions for treating pulmonary tuberculosis, the drug provided by the invention has no toxic or side effect on the body of a drug user, and also has the characteristics of definite curative effect, short treatment and medication time, quick effect, low price and the like.

The invention discloses a traditional Chinese medicine for resisting malignant tumors. The traditional Chinese medicine is prepared from, by weight, radix ophiopogonis, saposhnikovia divaricata, fried codonopsis pilosula, glossy ganoderma, fructus forsythiae, portulaca oleracea, fruits of Chinese wolfberry, scorched hawthorn fruits, dogwood, schisandra chinensis, poria cocos, manyinflorescenced sweetvetch roots, cortex lycii radicis, radix glehniae, lily, oroxylum indicum, thunberg fritillary bulb, radix tetrastigme, dried rehamnnia roots, moutan bark, bighead atractylodes rhizome, fried scutellaria baicalensis, radix ranunculi ternati, oldenlandia diffusa, herba tripterospermi, fried pueraria lobata and Chinese pulsatilla roots. The medicine takes effect rapidly after being decocted, is reliable in treatment effect, has no obvious side effects, is mainly used for strengthening the body resistance and helps patients to regulate spleen and stomach and benefit Qi and blood.

The invention relates to 5-fluorouracil containing pharmaceutical composition and an application of the 5-fluorouracil containing pharmaceutical composition in preparation of an anti-tumor injection. The injection comprises an injection solution and freeze-dried powder injection. Lithospermic acid and 5-fluorouracil can have an obvious synergistic effect, hepatocellular carcinoma growth is inhibited, side effects of chemotherapy are reduced, immunity is enhanced, and the purpose of tumor therapy is achieved finally, so that one simple and effective treatment means is provided for patients with advanced liver cancer, especially patients intolerant to a normal dose of 5-fluorouracil.

The invention discloses a traditional Chinese medicine prescription with functions of strengthening the spleen and nourishing blood and a preparation method thereof. The traditional Chinese medicine prescription is prepared from the following components in parts by weight: 25-35g of hairyvein agrimonia herb and bud, 55-65g of milk-vetch roots, 15-25g of white atractylodes rhizomes, 35-45g of glossy privet fruits, 35-45g of yerbadetajo herb, 25-35g of solomonseal rhizomes, 35-45g of lucid ganoderma, 55-65g of peanut coat, 15-25g of folium pyrrosiae, 25-35g of donkey-hide gelatin, 35-45g of unprocessed rehmannia roots, 15-25g of Chinese angelica, 55-65g of white peony roots, 35-45g of suberect spatholobus stems, 15-25g of parched hawthorn fruits, 25-35g of bamboo shavings, 15-25g of processed pinellia tubers and 4-8g of prepared liquorice. Compared with the prior art, the prescription has good effects of strengthening the spleen and replenishing qi, nourishing liver and kidney and enriching and regulating blood, and is capable of enhancing the immunity of human body, helping the human body, alleviating toxic and side effects of chemotherapy drugs, protecting the functions of visceraand bone marrow while chemotherapy is carried out, and ensuring the smooth progress of chemotherapy.

The invention discloses carrot-flavored sweet potato vermicelli and a preparation method thereof. The carrot-flavored sweet potato vermicelli is prepared from the following raw materials in percentage by weight: 40-80 parts of sweet potato starch and 10-20 parts of carrots. The preparation method comprises the following steps: cleaning fresh carrots, and squeezing the cleaned carrots into carrot juice; taking pretreated sweet potato starch according to desired weight parts, adding water, carrying out uniform stirring to form slurry, conducting standing for layering, and taking a bottom precipitation layer as the sweet potato starch; and mixing the carrot juice with the sweet potato starch treated in the step (2) according to a formula ratio, and conducting processing to form vermicelli, namely the carrot-flavored sweet potato vermicelli. According to the invention, nutritional ingredients in the carrot juice are fully added into a vermicelli product, so a vermicelli food product market is enriched, and the product has the nutritional and health-care effects of invigorating the spleen, promoting digestion, relieving diapause, tonifying the liver, improving eyesight, descending qi, relieving cough, clearing away heat and toxic materials, promoting appetite, delaying senescence, reducing blood pressure, reducing cholesterol, regulating blood sugar, preventing allergy, preventing and resisting cancers, reducing side effects of chemotherapy, improving body immunity and the like.

The invention discloses a nursing medicament for relieving cancer patient chemotherapy side reactions. The medicament is prepared from, by weight, 8-14 parts of centella, 6-9 parts of tremmella, 9-15 parts of rehmannia glutinosa, 5-10 parts of polygonum multiflorum, 4-11 parts of hawthorn fruits, 7-13 parts of saussurea involucrate, 6-15 parts of lotus seeds, 6-9 parts of medical stone, 1-5 parts of corn and 1-9 parts of bunge cherry seeds. According to the medicament, the channel affinity medicine with the high spicy passing effect is selected, the medicine directly acts on an effected part, main and collateral channels are transferred, the effects of improving immunity, enhancing appetite and relieving pain are achieved, and the medicament can be used for relieving cancer patient chemotherapy side reactions such as diarrhea, alopecia and fatigue.

The invention provides application of carvedilol to preparation of a STING agonist and a chemotherapeutic sensitization drug. According to the invention, it is found that the carvedilol can specifically recognize STING and activate a cGAS-cGAMP-STING signal path, and then an anti-tumor immune response is amplified, and the lifetime of a tumor patient is prolonged. The STING agonist not only can enhance the chemotherapeutic effect and solve the problem of chemotherapy resistance, but also can reduce the chemotherapeutic side effect, and can improve the life quality of a patient while prolonging the lifetime of the tumor patient.

The invention relates to a Chinese materia medica preparation, in particular to a traditional Chinese composition of Beiqi lung supplement tablet used for phithis, which is particularly applicable to Qiyin damage symptoms of secondary tuberculosis of lung. The traditional Chinese composition is prepared by the materials of the following weight portions: 120 to 180 portions of milk veteh, 60 to 90 portions of lily roots, 60 to 90 portions of ophiopogon roots, 45 to 75 portions of fritillary bulb, 90 to 135 portions of ordate houttuynia, 90 to 135 portions of Radix picrorrhizae, 75 to 110 portions of ternate buttercup roots, 90 to 135 portions of stemona, 60 to 90 portions of balloon flower, 30 to 45 portions of Panaxnotoginseng, and 60 to 90 portions of Bletilla striata. The traditional Chinese composition has the effects of supplementing qi and nourishing yin, moistening the lung and relieving the cough, and growing muscles and stanching bleeding, can rapidly relieve tuberculosis symptoms, has relatively ideal effects in the major aspects of preventing cough, eliminating phlegm, stanching bleeding, resisting inflammation, regulating immune and the like, and can reduce side-effectsof chemo-treatment, facilitate sputum negative conversion, focus absorption and pore closure. The side-effects are small and the medical healing effects are reliable; moreover, the traditional Chinese composition is worthy of being popularized and applied.

The invention discloses a medicine composition for treating malignant pleural effusion and a preparation method of the medicine composition. The medicine composition is prepared from the following raw materials by weight: 15-25 parts of rabdosia rubescens, 10-20 parts of curcuma wenyujin, 5-15 parts of brucea javanica, 5-15 parts of radix sophorae flavescentis, 8-12 parts of arisaema erubescens, 8-12 parts of poria cocos, 7-13 parts of fructus aurantii, 5-15 parts of glossy privet fruit, 12-18 parts of herba epimedii, 7-13 parts of konjak, 12-18 parts of rice sprout, 15-25 parts of oldenlandia, 15-25 parts of sculellaria barbata, 5-13 parts of paris polyphylla, 7-13 parts of centipede, and 2-10 parts of scabrous elephantfoot herb; the various materials are extracted with water or ethyl alcohol to prepare the medicine composition, the chemotherapy is conducted with the medicine composition at the same time, the excellent synergistic interaction effects are achieved, no effect of inhibiting the bone marrow is produced, the synthesis of RNA and the protein is also not affected, the medicine composition has a remarkable effect of inhibiting the adhesion of a vascular endothelial cell of a neoplastic cell nuclei, directly stimulates pleura to lead to adhesion and fibrosis, has the effects of strongly astringing and inhibiting the secretion of the pleura, is an effective medicine for treating the malignant pleural effusion, and has a huge clinical application prospect.

The invention discloses a stomach nourishing preparation for relieving the chemotherapy side effect of a tumor patient and a preparing method thereof. The stomach nourishing preparation is prepared from, by weight, 8-16 parts of barbed skullcap herbs, 3-12 parts of asiatic pennywort herbs, 6-12 parts of green onion, 0.2-0.6 part of pearl powder (soaked in vinegar), 6-14 parts of apples, 20-35 parts of spreading hedyotis herbs, 6-15 parts of marasmius androsaceus, 6-15 parts of radix angelicae sinensis (wine-processed), 6-12 parts of hericium erinaceus, 3-6 parts of corn, 2-8 parts of tomatoes, 3-9 parts of millet and 5-9 parts of radix angelicae pubescentis. The stomach nourishing preparation is scientific in formula and simple in preparation method, and therefore the obtained product is convenient to take and carry. In addition, the stomach nourishing preparation has the advantages of taking effect faster and more comprehensively, treating manifestation and root causes of diseases and being more remarkable in treatment effect, capable of effectively treating adverse effects caused by cancer pain, fever and chemotherapy and capable of effectively relieving the chemotherapy side effect of the tumor patient.

The invention discloses a ginseng mushroom health product and a preparation method thereof, belonging to the technical field of health products. The Shenqi monkey mushroom health product of the present invention comprises the following component A, component B and component C, wherein: the formula of the component A is: 25 parts of Hericium erinaceus; 15 parts of shiitake mushrooms; 15 parts of wild ginseng; 10 parts of Astragalus; 5 parts of Zhemu; 5 parts of Polygonum cuspidatum; 4 parts of Salvia; 3 parts of Lily; 3 parts of Trichosanthes root; 3 parts of Hawthorn; 3 parts; 5 parts of catechu; the formula of the component C is: 30 parts of rice vinegar; 20 parts of honey. The Shenqi monkey mushroom health product of the present invention has good effect on preventing and treating cancer, has the function of preventing tumor cell growth, improving immunity and reducing side effects of chemotherapy for cancer patients undergoing radiotherapy and chemotherapy, antiviral effect, and improving the human body's ability to resist disease against tumor cells. Disease-free play a preventive role.