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Preparation method for antrodia extract and antrodia composition and pharmaceutical composition

The technology of extract and composition is applied in the application field of edible and medicinal fungi, which can solve the problems of patient side effects, influence treatment and other problems, and achieve the effect of reducing the side effects of chemotherapy

Pending Publication Date: 2019-05-31
YONGTENG SHENGJI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although chemotherapy can successfully kill cancer cells, it does not selectively kill normal cells, which usually has serious side effects on patients; low white blood cell count caused by chemotherapy drugs is one of the common side effects, cancer patients During chemotherapy, the number of white blood cells is often too low to affect the treatment

Method used

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  • Preparation method for antrodia extract and antrodia composition and pharmaceutical composition
  • Preparation method for antrodia extract and antrodia composition and pharmaceutical composition
  • Preparation method for antrodia extract and antrodia composition and pharmaceutical composition

Examples

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preparation example Construction

[0023] see figure 1 , the Antrodia camphorata extract provided in the embodiment of the present invention is obtained by extracting the Antrodia camphorata fruiting body in a dish through an ethanol solution, absorbing it with a macroporous resin, placing it in a rectangular container for partial purification, and obtaining a sub-extract. The preparation method includes Follow the steps below:

[0024] Step S101: take 1 kg of Antrodia antrodia fruiting body powder, soak and stir for 72 hours in 10 times the volume of an ethanol solution with a volume fraction of 95%, and then filter;

[0025] Step S102: soak and stir the filter residue obtained after step S101 extraction with 10 times the volume of ethanol solution with a volume fraction of 95% for 72 hours, and then filter;

[0026] Step S103: Mix the filtrate obtained in step S101 and the filtrate obtained in step S102, and use a vacuum rotary concentrator to concentrate to 5% of the original volume to obtain a crude extrac...

Embodiment 1

[0038] Example 1: Preparation of Antrodia Antrodia Extract

[0039]Get 1 kilogram of dish culture Antrodia camphorata fruiting body powder, soak and stir after 72 hours with the ethanol solution of 95% volume fraction with 10 times volume, suction filter, collect the filtrate for the first time. The filter residue after filtration was soaked and stirred with 10 times volume of 95% ethanol solution again for 72 hours, then filtered by suction, and the filtrate was collected for the second time. The two filtrates were combined and concentrated under reduced pressure to obtain the ethanol crude extract of Antrodia camphorata. After the crude extract is diluted 10 times with secondary water and 95% ethanol solution by volume fraction (the volume ratio of secondary water and 95% ethanol solution is 40:60), pour into a container containing about crude extract 5 times the weight of macroporous resin (for example, HP20) in a rectangular container, stir well and allow it to adsorb ...

Embodiment 2

[0041] Embodiment 2: preparation of mycelia extract of Antrodia camphorata

[0042] Take 1 kg of mycelia powder of Antrodia camphorata, boil it with 10 times the volume of secondary water for 8 hours, and then filter. The filtered filter residue was boiled with 10 times the volume of secondary water for 4 hours, and then filtered. The filtrate obtained twice was mixed, and concentrated to 5% of the original volume with a vacuum rotary concentrator. The concentrated solution of gained is added the ethanol solution that the volume fraction of 3 times of volumes is 70%, gets precipitate after filtering, and obtains the Antrodia camphorata mycelia extract after drying the precipitate.

[0043] It should be noted that in practical applications, the volume fraction of the concentrated solution added with 3 times the volume of ethanol solution can also be 60%, 65%, 75% or 80%. For the concentrated solution adding different volume fractions of ethanol solutions, this embodiment will...

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Abstract

The invention discloses a preparation method of an antrodia extract, and belongs to the technical field of application of edible and medicinal fungi. The method comprises extracting vessel-cultured antrodia sporocarp powder with an ethanol solution and conducting vacuum concentration on a filtrate to obtain a crude extract; adsorbing the crude extract with macroporous resin, placing the mixture ina rectangular container, washing the mixture out with a mixed solution, conducting vacuum concentration on an eluent, drying to obtain a first sub extract of the antrodia contract, then washing out with the ethanol solution, conducting vacuum concentration on the eluent, drying to obtain a second sub extract of the antrodia contract, washing out with an ethyl acetate solution, conducting vacuum concentration on the eluent and drying to obtain a third sub extract of the antrodia contract. The invention also provides a preparation method for an antrodia composition and a pharmaceutical composition. The sub extracts of the antrodia extract or the antrodia composition can be used for treating cancer and reducing side effects of chemotherapy.

Description

technical field [0001] The present invention relates to the technical field of the application of edible and medicinal fungi, in particular to a method for preparing antrodia camphorata extract, antrodia camphorata composition and a pharmaceutical composition for treating cancer and alleviating the side effects of chemotherapy. Background technique [0002] Antrodia cinnamomea (Antrodia cinnamomea) is a perennial fungus, which belongs to the order of Non-Zerobacteriaceae, polyporous bacteria material, genus Thyloporia, and Antrodia camphorata. , anti-virus, anti-inflammation, antioxidant effect and liver protection effect and other functions. Among them, anti-tumor related research and patents are mostly focused on directly using Antrodia camphorata fruiting body or mycelium powder or extracts of different solvents or a single compound on cancer cells. [0003] Due to the scarcity of wild Antrodia camphorata and the problem of environmental pollution, artificial cultivation...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/07A61P35/00A61K33/243
CPCA61P35/00A61K36/07A61K2236/00A61K33/243A61K2236/333A61K2236/51A61K2236/53
Inventor 钟承翰钟佳颖
Owner YONGTENG SHENGJI
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