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Drug for treating malignant pleural effusion with Qi and Yin deficiency

A technology for malignant pleural effusion and deficiency of both qi and yin, which is applied in the field of traditional Chinese medicine and can solve the problems of protein loss, aggravation of symptoms, severe vomiting, etc.

Inactive Publication Date: 2016-01-27
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The outstanding advantage of this method is that it can quickly relieve symptoms, but it is inevitable that some patients will lose a large amount of protein due to pumping pleural effusion, and the symptoms will aggravate; some patients will have fever and severe vomiting after intrathoracic injection of drugs.

Method used

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Effect test

preparation example Construction

[0051] The present invention also provides a preparation method for the above-mentioned pharmaceutical granules, which includes:

[0052] The first step is to weigh Codonopsis pilosula, Acanthopanax, Scrophulariaceae, Plantago, rhubarb, Chinese yam, red door orchid, curculi, grass lovage and asparagus, and mix them together with alcohol concentration of 70%~ 80% ethanol solution is heated and refluxed for 2 extractions, and the time for each extraction is 1 to 2 hours. The weight ratio of the ethanol solution and the Chinese medicinal materials mixed together in this step is 5 to 8: 1, and the extract is collected and filtered. Concentrate the filtrate under reduced pressure to a concentrated solution with a relative density of 1.02 to 1.06 at 60°C, and put it on a macroporous adsorption resin column. The weight of the macroporous adsorption resin is 1 to 3 times the weight of the Chinese medicinal materials mixed together in this step. The ethanol solution with a concentratio...

Embodiment 1

[0056] Embodiment 1 Granule 1

[0057]Weigh 60g of Codonopsis, 35g of Acanthopanax, 15g of Scrophulariaceae, 25g of Plantago, 20g of Rhubarb, 25g of Chinese Yam, 15g of Red Gateland, 30g of Curculigo, 15g of Duhuo and 25g of Asparagus, and mix them with 2kg alcohol concentration Heating and refluxing 80% ethanol solution for 2 extractions, each extraction time is 2 hours, collecting the extract, filtering, concentrating the filtrate under reduced pressure to a concentrated solution with a relative density of 1.06 at 60°C, and putting it on a macroporous adsorption resin column , the weight 500g of macroporous adsorption resin, be 50%, 60% and 80% ethanol solution eluting with alcohol concentration, the volume of each described eluent is 5 times of macroporous adsorption resin column volume, collects elution Liquid, concentrated into a clear paste with a relative density of 1.15 at 55°C, weighed 20g of Tinglizi, 15g of Ephedra, 15g of Guizhi, 15g of Morus alba, 15g of honeysuck...

Embodiment 2

[0060] Embodiment 2 Granules 2

[0061] Weigh 58g of Codonopsis, 33g of Acanthopanax, 13g of Scrophulariaceae, 23g of Plantago, 18g of Rhubarb, 23g of Chinese Yam, 13g of Red Door Orchid, 28g of Curculigo chinensis, 13g of Duhuo and 23g of Asparagus, and mix them together with 2kg alcohol concentration Heating and refluxing 80% ethanol solution for 2 extractions, each extraction time is 2 hours, collecting the extract, filtering, concentrating the filtrate under reduced pressure to a concentrated solution with a relative density of 1.06 at 60°C, and putting it on a macroporous adsorption resin column , the weight 500g of macroporous adsorption resin, be 50%, 60% and 80% ethanol solution eluting with alcohol concentration, the volume of each described eluent is 5 times of macroporous adsorption resin column volume, collects elution liquid, concentrated into a clear paste with a relative density of 1.15 at 55°C, weighed Tinglizi 18g, Ephedra 13g, Guizhi 13g, Morus alba 13g, Hone...

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Abstract

The invention provides a drug for treating malignant pleural effusion with Qi and Yin deficiency, comprising materials: Radix Codonopsis, Radix Acanthopanacis Semticosi, Radix Scrophulariae, Semen Plantaginis, Semen Lepidii, Herba Ephedrae, Ramulus Cinnamomi, Radix et Rhizoma Rhei, Cortex Mori, Rhizoma Dioscoreae, Herba Orchidis Latifoliae, Radix Morinaceae, Radix Araliae, Radix Asparagi, Flos lonicerae, Herba Cymbopogonis, Herba seu Radix Asteris Ageratozdis, and pollen typhae. An effective means to treat malignant pleural effusion is given using the drug with chemotherapy through pleural perfusions, thus recurrence rate of pleural effusion of lung cancer is decreased and curative effect is improved, toxic and side effects of chemotherapy can also be relieved and the curative effect can also be enhanced, by using traditional Chinese medicine, and meanwhile, life quality of a patient is improved and clinical symptoms are relieved, both the entirety and locality of the patient are cared and the purpose of strengthening body resistance and eliminating evil is achieved.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a medicine for treating malignant pleural effusion of Qi and Yin deficiency type. Background technique [0002] Malignant pleural effusion refers to pleural effusion caused by malignant tumor involving the pleura or primary pleural tumor. It is one of the common complications of malignant tumors in the late stage, and the incidence rate accounts for about 25% of pleural effusions. Malignant tumors that cause malignant pleural effusions include lung cancer, breast cancer, and lymphoma. Clinically, it can cause symptoms such as chest pain and dyspnea, and even respiratory failure, which seriously affects the quality of life of patients and shortens the survival time of patients. Some studies have shown that the survival time is generally less than 6 months. The rapid growth of malignant pleural effusion can cause compressive atelectasis and restrictive ventila...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61P7/10A61P35/00
Inventor 王伦青
Owner QINGDAO MUNICIPAL HOSPITAL
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