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Application of small-molecular citrus pectin

A small-molecule, citrus-based technology, applied in the field of new applications of small-molecule citrus pectin, can solve problems such as enhancing anti-tumor effects, and the immune regulation function of small-molecule citrus pectin that has not been involved

Inactive Publication Date: 2015-09-02
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there have been no reports on the application of small-molecule citrus pectin in the field of anti-tumor pharmaceuticals, and it has not been mentioned that small-molecule citrus pectin can have immune regulation function, and can achieve the effect of sensitization and detoxification of chemotherapeutic drugs when combined with chemotherapy, and assist in enhancing Anti-tumor effect, function of reducing toxicity and side effects of chemotherapy

Method used

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  • Application of small-molecular citrus pectin
  • Application of small-molecular citrus pectin
  • Application of small-molecular citrus pectin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Purchase the small-molecule citrus pectin powder from Santerai Company in the United States, and directly use it as a health care product for anti-tumor and immune function improvement. Take 15g three times a day, and each 5g can be dissolved in 50-200ml of hot water. After mixing evenly, Drink it directly, or add it to fruit juice or puree.

Embodiment 2

[0076] Purchase the small-molecule citrus pectin powder from Santerai Company in the United States, use the capsule material made of edible gelatin, fill it into capsules, and make it as an adjuvant drug for tumor chemotherapy that improves immune function and has anti-tumor activity, divided into three times a day Take, and reach daily oral effective dose and be 15g and get final product.

Embodiment 3

[0078] Take 90% small molecule citrus pectin, 5% licorice, and 5% hawthorn powder by mass percentage, and make tablets according to known tableting technology and equipment, that is, take all the ingredients in the above formula and mix them evenly, punch them into tablets, and make As an adjuvant drug for tumor chemotherapy that improves immune function and has anti-tumor activity, the daily oral effective dose is 15 g.

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Abstract

The invention discloses a new application of small-molecular citrus pectin. The small-molecular citrus pectin can be used for preparing anti-tumor auxiliary medicines which have immunoregulation effects and can be used for cooperating with the effect-enhancing and toxicity-reducing action of chemotherapy medicines, or can be used for preparing health products with anti-tumor auxiliary effects. A compound disclosed by the invention cannot be used for directly killing tumor cells when being separately used, and does not have anti-tumor effects; the compound can be taken as an auxiliary medicine, can cooperate with the chemotherapy medicines for use, can have immunoregulation functions on T cells and MDSC cells by virtue of ligands on the surfaces of antagonistic immune cells and tumor tissue cells of the compound, can be used for enhancing the anti-tumor effects in an auxiliary mode, and ensures that the sensitivity-enhancing and toxicity-reducing effects on tumor chemotherapy can be achieved; and new medical applications of the known compound namely the small-molecular citrus pectin can be explored, and a new application field can be created.

Description

technical field [0001] The invention relates to the application of small molecule citrus pectin, in particular to a new application of small molecule citrus pectin. Background technique [0002] The development and utilization of citrus pectin has a long history. It is recorded in "Compendium of Materia Medica" by Li Shizhen of the Ming Dynasty: "Orange peel, bitterness can relieve dryness, pungentness can be dispersed, and temperature can be gentle. It can cure all diseases and treat all diseases. It is the merit of regulating qi and drying dampness." After being dried in the sun or dried in the shade, the traditional Chinese medicine tangerine peel has the effects of regulating qi and invigorating the spleen, warming the stomach and dispelling cold, drying dampness and resolving phlegm. Low-molecular-weight Citrus Pectin (LCP) is the second-generation product of American Santerai Company following the "Modified citrus pectin" (MCP) made from orange peel. (Pratima Nangia-M...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/732A61P35/00A23L1/09
Inventor 袁瑛张苏展沈彦伟谭纯文李晶晶曹莹郑树
Owner ZHEJIANG UNIV
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