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Traditional Chinese medicine embolization microspheres used for interventional treatment of liver cancer at middle and advanced stages and preparation method of traditional Chinese medicine embolization microspheres

A technology of interventional therapy and embolization of microspheres, which is applied in the field of medicine, can solve the problems of drug resistance of tumor cells, easy occurrence of collateral circulation, and difficulty in entering tumor cells, etc., so as to inhibit the occurrence of drug resistance, have low toxic and side effects, and improve life quality. quality effect

Active Publication Date: 2019-10-22
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a traditional Chinese medicine embolization microsphere for the interventional treatment of advanced liver cancer, which solves the problem that collateral circulation is prone to occur in the clinical use of traditional embolization microspheres in the embolization interventional treatment of advanced liver cancer, and at the same time solves the problem of Traditional anti-tumor drugs are not easy to enter tumor cells and can easily induce drug resistance in tumor cells

Method used

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  • Traditional Chinese medicine embolization microspheres used for interventional treatment of liver cancer at middle and advanced stages and preparation method of traditional Chinese medicine embolization microspheres
  • Traditional Chinese medicine embolization microspheres used for interventional treatment of liver cancer at middle and advanced stages and preparation method of traditional Chinese medicine embolization microspheres
  • Traditional Chinese medicine embolization microspheres used for interventional treatment of liver cancer at middle and advanced stages and preparation method of traditional Chinese medicine embolization microspheres

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preparation example Construction

[0037] The preparation method of traditional Chinese medicine embolization microspheres for interventional treatment of advanced liver cancer is characterized in that it comprises the following steps of specific preparation:

[0038] Step 1: Weigh 75.48% to 81.99% of Baiji polysaccharide, 0.5% to 1.5% of sodium cantharidate, 2.5 to 3.0% of lecithin, 0.01 to 0.02% of cholesterol and 15% to 20% of 1,2-propanediol according to the mass percentage , the sum of the mass percentages of the above components is 100%;

[0039] Step 2: Add the 1,2-propanediol and sodium cantharidate weighed in step 1 into water for injection, dissolve to obtain a sodium cantharidate solution, and keep it warm at 50°C; add the lecithin and cholesterol weighed in step 1 Shake and dissolve with absolute ethanol for injection, then put it into the sodium cantharidinate solution, and stir for 15-20min under the protection of nitrogen atmosphere of 1.5-1.8MPa, the stirring speed is 1300-1500r·min -1 , and th...

Embodiment 1

[0055] Step 1: Weigh 81.99% (81.99g) of Baiji polysaccharide, 0.5% (0.5g) of sodium cantharidinate, 2.5% (2.5g) of lecithin, 0.01% (0.01g) of cholesterol and 1,2- Propylene glycol 15% (15mL), the sum of the mass percentages of the above components is 100%.

[0056] The lecithin, cholesterol and 1,2-propanediol mentioned above are all injection-grade pharmaceutical excipients.

[0057] Step 2: Add 0.5g of sodium cantharidate and 15mL of 1,2-propanediol for injection into 50mL of water for injection weighed in step 1, dissolve to obtain sodium cantharidate solution, and keep warm at 50°C; weigh 2.5g Lecithin for injection and 0.01g of cholesterol for injection were added to 10mL of absolute ethanol for injection and shaken to dissolve, then injected into the sodium cantharidate solution obtained above, and stirred for 15min under the protection of a nitrogen atmosphere of 1.5MPa, stirring The speed is 1300r·min -1 , and then circulated and filtered through a 0.22 μm microporou...

Embodiment 2

[0062] Step 1: Take by weighing 75.48% Baiji polysaccharide (75.48g), sodium cantharidate 1.5% (15g), lecithin 3.0% (3.0g), cholesterol 0.02% (0.02g) and 1,2- Propylene glycol 20% (20mL), the sum of the mass percentages of the above components is 100%.

[0063] The lecithin, cholesterol and 1,2-propanediol mentioned above are all injection-grade pharmaceutical excipients.

[0064] Step 2: Add 1.5g of sodium cantharidate and 20mL of 1,2-propylene glycol for injection weighed in step 1 into 45mL of water for injection, dissolve to obtain a sodium cantharidate solution, and keep warm at 50°C; weigh step 1 Add 3.0g of lecithin for injection and 0.02g of cholesterol for injection into 10mL of absolute ethanol for injection and shake to dissolve, then inject it into the sodium cantharidate solution obtained above, and stir under the protection of a nitrogen atmosphere of 1.6MPa 20min, the stirring rate is 1500r·min -1 , and then circulated and filtered through a 0.22 μm microporous ...

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Abstract

The invention discloses traditional Chinese medicine embolization microspheres used for interventional treatment of liver cancer at middle and advanced stages. The traditional Chinese medicine embolization microspheres are prepared from, by mass, 75.48-81.99% of bletilla striata polysaccharide, 0.5-1.5% of sodium cantharidate, 2.5-3.0% of lecithin, 0.01-0.02% of cholesterol and 15-20% of 1,2-propylene glycol, and the mass percent of the above components is 100%. The invention further discloses a preparation method of the traditional Chinese medicine embolization microspheres. After embolization is conducted on the tissue of liver cancer at middle and advanced stages by adopting the traditional Chinese medicine embolization microspheres, through multiple ways and multiple levels such as thesynergetic embolization effects of mechanical embolization of the microsphere bodies and hemostasis, inflammation resistance and collateral circulation reconstruction inhibition of the bletilla striata polysaccharide, efficient target transferring for the sodium cantharidate into tumor cells by nanometer flexible liposomes, and inhibition for generation of medicine resistance of the tumor cells,the synergistic anticancer effect is exerted.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to traditional Chinese medicine embolization microspheres for interventional treatment of middle and advanced liver cancer, and also relates to a preparation method of the traditional Chinese medicine embolization microspheres. Background technique [0002] my country is a big country with hepatitis, and liver cirrhosis caused by hepatitis is the main risk of liver cancer; in addition, due to the heterogeneity of tumors and the limitations of current diagnostic methods, most patients with liver cancer are in the middle and late stages when they are discovered. [0003] At present, in addition to the three major therapies such as surgery, chemotherapy and radiotherapy, there are new methods such as targeting, immunity and minimally invasive intervention in the treatment of liver cancer. Different therapies have their own advantages and disadvantages: ①Surgery, the first o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00A61K31/34A61K31/715A61K9/52A61K47/36A61P35/00
CPCA61K9/5036A61K31/34A61K31/715A61L24/001A61L24/0015A61L24/08A61L2300/232A61L2300/41A61L2300/416A61L2300/602A61L2400/04A61P35/00A61K2300/00
Inventor 李伟泽赵宁韩文霞梁飞付丽娜孙艳平杨黎彬周永强
Owner XIAN MEDICAL UNIV
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