Use of medicinal composition containing lotus leaves and hypericum japonicum total flavone extraction in preparing medicine for hepatitis B virus

A technology of total flavonoids and extracts, applied in antiviral agents, drug combinations, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2010-12-29
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research results of many scholars have shown that Tian Jihuang can significantly increase the phagocytosis rate of peripheral blood neutrophils (PMN), the ratio of T lymphocytes, the rate of spleen-specific antibody-forming cells, and the number of specific rosette-forming cells, but it can inhibit the migration of blood leukocytes. phagocytosis of alveolar macrophages

Method used

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  • Use of medicinal composition containing lotus leaves and hypericum japonicum total flavone extraction in preparing medicine for hepatitis B virus
  • Use of medicinal composition containing lotus leaves and hypericum japonicum total flavone extraction in preparing medicine for hepatitis B virus
  • Use of medicinal composition containing lotus leaves and hypericum japonicum total flavone extraction in preparing medicine for hepatitis B virus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1. Extract the total flavonoids of lotus leaf and Tianjihuang: take 300 grams of lotus leaf and Tianjihuang medicinal materials, extract three times with 50-95% alcohol, concentrate the extract to 1 / 4-1 / 5 volume, and put it on D101 macropore Resin, eluted with water and 70% alcohol, collected the eluate, verified by magnesium powder / hydrochloric acid detection, collected the part with high flavonoid content, concentrated the eluate to dryness to obtain a solid, that is, the effective part product, weighed and determined the total flavonoids content.

[0020] Table 1 is the extraction yield and total flavonoid content of lotus leaf total flavonoids.

[0021] Table 2 is the extraction yield and total flavonoid content of Tianjihuang total flavonoids.

[0022] Table 1

[0023]

[0024] Note: The total flavonoid content is the content of flavonoids in the total flavonoid extract

[0025] Table 2

[0026]

[0027] 2. Take the extract of total flavonoids of lotus ...

Embodiment 2

[0035] Take 50 grams of lotus leaf total flavonoids extract and 25 grams of Tianjihuang total flavonoids extract, pulverize and mix them through a 100-mesh sieve, add 3 grams of starch and mix evenly, then add 10% starch slurry to make a soft material, 20-mesh sieve Granulate, dry at 60-70°C, pass through a 30-mesh sieve for granulation, add 3 grams of hydroxypropyl cellulose and 1 gram of magnesium stearate, mix well, press into tablets, and film-coat to obtain tablets: 1000 pieces.

Embodiment 3

[0037] Get 50 grams of lotus leaf total flavonoids extract and 25 grams of Tianjihuang total flavonoids extract, pulverize and mix through a 100-mesh sieve, add 3 grams of starch, appropriate amount of microcrystalline fiber, granulate with dilute ethanol, and granulate with a 20-mesh sieve. Dry at 60-70°C, granulate, add appropriate amount of magnesium stearate, mix thoroughly, fill into capsules to obtain capsules, 1000 capsules.

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Abstract

The invention relates to a medicament complex which is prepared from total flavone extract of lotus leaf and hypericum japonicum thunb, and new usage for preparing anti-hepatitis B virus medicament. The total flavone of lotus leaf and hypericum japonicum thunb of the invention is total flavone extract which is separated and extracted from lotus leaf and hypericum japonicum thunb which grow in China. The complex of lotus leaf and hypericum japonicum thunb is separated and purified, tested by mass spectrum, 13C and 1HNMR, and proved to contain the following chemical components: quercetin, quercetin-3-O-beta-D-galactopyranose, isoquercetin, and kacmpferol and the like. The complex of total flavone extract is tested by in vitro cell model and in vivo animal model and proved to have strong activity of resisting hepatitis B virus and protecting liver. The complex of total flavone extract can be further prepared into anti-hepatitis B virus medicament and dosage forms can be capsules, tablets, granules, and injection and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to anti-hepatitis B virus drugs, in particular to a drug compound containing lotus leaf and tianjihuang total flavonoid extracts and its application in preparing anti-hepatitis B virus drugs. Background technique: [0002] The lotus leaf is the dry leaf of Nelumbo nucifera Gaertn., a plant of the water lily family, and is a food for both medicine and food. Lotus leaf is bitter, flat, returns liver, spleen, stomach meridian, is used for hot summer heat and polydipsia, summer-heat-damp diarrhea, diarrhea due to spleen deficiency, blood-heat vomiting at the nose, bloody stool and metrorrhagia. Studies have shown that lotus leaf is rich in a variety of active ingredients, such as: carotene, flavonoids, volatile oils, soaps, steroids, etc. Alkali and other alkaloids. The flavonoids rich in lotus leaf are scavengers of most oxygen free radicals, which can increase the activity...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K31/7048A61P1/16A61K36/62A61P31/12
Inventor 李继扬周珮黄海盛德鑫
Owner FUDAN UNIV
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