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Thrombi-resistant application of dihydroxyphenyl lactate

A technology of dihydroxyphenyl lactic acid and hydroxyphenyl lactic acid, applied in the treatment and prevention of thrombus, field of salvia miltiorrhiza extract dihydroxyphenyl lactic acid

Inactive Publication Date: 2009-09-16
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, aspirin's hemorrhagic side effects prompted the development of new antithrombotic treatments

Method used

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  • Thrombi-resistant application of dihydroxyphenyl lactate
  • Thrombi-resistant application of dihydroxyphenyl lactate
  • Thrombi-resistant application of dihydroxyphenyl lactate

Examples

Experimental program
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Effect test

Embodiment 1

[0062] Case 1

[0063] A 61-year-old man had a sudden cerebral thrombosis. He went to the hospital for examination: CT and MRI showed infarction in the left temporoparietal lobe and brainstem area. He was treated with dihydroxyphenyl lactic acid injection, a course of seven days, and the numbness of his hands and feet disappeared after use. After the second course of treatment, I was able to yell, and I didn’t need to be helped to go to the toilet, and I was able to walk with crutches; after the third course of treatment, I spoke clearly and walked freely.

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Abstract

The invention relates to the new application of the Chinese traditional medicine, in particular to the application of salvia extract, namely dihydroxyphenyl lactate in the treatment and prevention of thrombi. The test data indicate that the dihydroxyphenyl lactate can delay the time from the stimulation to the formation of thrombi and can prolong the half-volume time of the thrombi.

Description

Technical field: [0001] The invention relates to a new application of traditional Chinese medicine products, in particular to the application of salvia miltiorrhiza extract dihydroxyphenyl lactic acid in the treatment and prevention of thrombus. Background technique: [0002] Salvia miltiorrhiza is a traditional Chinese medicine in China, and its main water-soluble ingredients are dihydroxyphenyl lactic acid (danshensu), methyl tanshinate, hypotanshinone, salvianol, β-sitosterol, β-sitosterol, 3,4- Dihydroxybenzaldehyde, catechin, rutin, protocatechualdehyde, protocatechuic acid, lactic acid, vitamin E, etc. After oral administration of salvianolic acid compounds, the main water-soluble components of Salvia miltiorrhiza that can be detected in serum dihydroxyphenyl lactic acid [0003] [0004] Also known as: Danshensu-D(+)β-(3,4-dihydroxyphenyl) lactic acid [1] is the basic structural component of various water-soluble components of Danshen, and has been proven to have ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61K9/08A61P7/02
Inventor 韩晶岩刘育英刘连欹孙凯王传社
Owner TIANJIN TASLY PHARMA CO LTD
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