Piprazine compound containing polysulfide bond and preparation method and application thereof

A kind of compound, technology of polysulfide bond, applied in the field of piperazine compound containing polysulfide bond and its preparation and use

Active Publication Date: 2010-08-25
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Formula I

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  • Piprazine compound containing polysulfide bond and preparation method and application thereof
  • Piprazine compound containing polysulfide bond and preparation method and application thereof
  • Piprazine compound containing polysulfide bond and preparation method and application thereof

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Abstract

The invention relates to a preparation method of a piprazine compound containing polysulfide bond and an application thereof. Fungus oidiodendron truncatum GW3-13 which is separated from the soil of Antarctic Great Wall Station is used for producing the piprazine compound containing the polysulfide bond with novel structure. The piprazine compound is proved to be used as cell proliferation inhibitor or hypoxia-inducible factor-1 (HIF-1) targeting antineoplastic agent.

Description

Technical field: The invention relates to a method for producing piperazine compounds (ETPs) containing polysulfide bonds by using Oidiodendron truncatum GW3-13 (preservation number: CCTCC M 2010043); Use of an inducible factor (HIF-1) targeting antineoplastic agent. Background technique: The present inventor once discovered piperazine compounds containing polysulfide bonds with obvious antitumor activity from the liquid fermentation product of Oidiodendron truncatum GW3-13 (preservation number: CCTCC M 2010043). Studies have found that the indicated piperazine compounds containing polysulfide bonds have cell proliferation inhibitory activity, cytotoxic activity and hypoxia-inducible factor (HIF-1) inhibitory activity, but there is no drug related to this in the market. Invention content: The present invention aims to provide a compound with unique structure, which can inhibit the proliferation of tumor cells and has anti-tumor activity. its structural formula Formula...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D519/00C12P17/18A61K31/554A61K31/548A61P35/00C12R1/645
Inventor 朱天骄顾谦群李莉媛李德海
Owner OCEAN UNIV OF CHINA
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