Anticoccidial solution containing toltrazuril and preparation method thereof

Abstract

The invention discloses an anticoccidial solution containing toltrazuril and a preparation method thereof. The anticoccidial solution is prepared from toltrazuril, polyethylene glycol 400 and dimethyl sulfoxide. The preparation method comprises the following steps of: mixing the polyethylene glycol 400 and the dimethyl sulfoxide, heating the mixture to 60 DEG C, adding the toltrazuril at the constant temperature of 60 DEG C, and uniformly stirring the solution at 60 to 70 rpm to obtain the anticoccidial solution containing toltrazuril. Other medicaments also can be added into the anticoccidial solution containing toltrazuril to prepare a compound anticoccidial solution containing toltrazuril. In the technology of the invention, the PEG 400 and the dimethyl sulfoxide are used as the solvent; the heating manner at the constant temperature of 60 DEG is applied to dissolve the solution, so that the toltrazuril can not be damaged and has high effective concentration and high dissolution speed; the constant-temperature stirring manner at the speed of 60 to 70 rpm is beneficial to maintaining the stability of the toltrazuril solution, so that the quality of the toltrazuril solution is ensured.

Description

technical field [0001] The invention relates to an anticoccidial solution containing toltrazuril and a preparation method thereof, belonging to the technical field of veterinary drug solutions. Background technique [0002] Chicken coccidiosis (Coccidiosis in Chicken) is a common and very serious parasitic disease in chickens, and the economic loss it causes is staggering. The morbidity and mortality of chicks are high. The growth of the sick chicks is hindered, and the weight gain is slow; the adult chickens are mostly worm carriers, and the weight gain and egg production capacity are reduced. Especially in areas with high temperature and high humidity, it is conducive to the growth and development of coccidia oocysts, and it is often explosive. Coccidiosis often causes morbidity in 15-50 day-old chicks, and the mortality rate is as high as 80%. Most types of coccidia parasitize in the intestinal tract and cause intestinal lesions. [0003] There are 7 species of Eimeri...

AI Technical Summary

Problems solved by technology

[0006] At present, most of the listed products of toltrazuril are powders and drinking water preparations, the effective concentration of which is low, and the stability of toltrazuril is poor, and precipitation and discoloration are prone to occur