Clindamycin phosphate solvate crystal and preparation method thereof

A technique for clindamycin phosphate and solvate, which is applied in the field of clindamycin phosphate solvate crystal and its preparation, and can solve problems such as poor stability of clindamycin phosphate

Active Publication Date: 2010-09-22
ZHUHAI EBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to solve the defect of poor stability of clindamycin phosphate

Method used

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  • Clindamycin phosphate solvate crystal and preparation method thereof
  • Clindamycin phosphate solvate crystal and preparation method thereof
  • Clindamycin phosphate solvate crystal and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] The preparation of embodiment 1 clindamycin phosphate n-butanol-water solvate crystal

[0063] Dissolve 4.8g of clindamycin phosphate in a mixed solvent of 40ml of n-butanol and 10ml of water, heat and stir at 40-50°C for 0.5-1 hour to dissolve, filter, and the filtrate evaporates naturally at room temperature, and white blocky crystals appear after 7 days. That is, clindamycin phosphate n-butanol-water solvate crystals.

Embodiment 2

[0064] The preparation of embodiment 2 clindamycin phosphate dimethyl sulfoxide-water solvate crystal

[0065] Dissolve 5.2g of clindamycin phosphate in a mixed solvent of 20ml of dimethyl sulfoxide and 20ml of water, heat and stir at 40-50°C for 0.5-1 hour to dissolve, filter, and the filtrate evaporates naturally at room temperature, and white needles appear after 7 days Clindamycin phosphate dimethyl sulfoxide-water solvate crystals.

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Abstract

The invention belongs to the technical field of medicine, in particular relating to a clindamycin phosphate solvate crystal and a preparation method thereof. The clindamycin phosphate solvate crystal comprises a clindamycin phosphate isobutanol-water solvate crystal and a clindamycin phosphate dimethyl sulfoxide-water solvate crystal which have good chemical stability and stable property in the storage process.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to a crystal of clindamycin phosphate solvate and a preparation method thereof. 2. Background technology [0002] Clindamycin phosphate is a derivative of clindamycin, which is inactive in vitro. It is rapidly hydrolyzed into clindamycin when injected into the body to exert pharmacological effects and inhibit bacterial protein synthesis. The antibacterial spectrum and antibacterial activity of clindamycin phosphate are the same as those of clindamycin, and it has antibacterial activity against gram-positive bacteria such as Staphylococcus aureus, Streptococcus pneumoniae and Streptococcus hemolyticus and most anaerobic bacteria. [0003] Clindamycin phosphate is a lactone compound, which is easily degraded in water, and its hydrolysis products are highly toxic. In addition, the structure and pharmacological properties of many degradation products are still unclear, wh...

Claims

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Application Information

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IPC IPC(8): C07H15/16A61P31/04
Inventor 张在富华荣庆吴建国吴浩山
Owner ZHUHAI EBANG PHARMA
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