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Application of fenugreek biflavone glycosides for preparing anti-virus or/and anti-tumor drugs

An anti-tumor drug, biflavone glycoside technology, which is applied in the direction of anti-tumor drugs, antiviral agents, drug combinations, etc., can solve the problems of unretrieved literature and no research reports of alopecia glucoside, and achieve strong anti-hepatitis B Virus effect, excellent anti-influenza drug effect, strong anti-HIV effect

Active Publication Date: 2012-10-03
XINJIANG INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] There are no research reports on the application of alopecia glycosides in the preparation of antiviral and antitumor drugs at home and abroad, and no relevant literature has been retrieved

Method used

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  • Application of fenugreek biflavone glycosides for preparing anti-virus or/and anti-tumor drugs
  • Application of fenugreek biflavone glycosides for preparing anti-virus or/and anti-tumor drugs
  • Application of fenugreek biflavone glycosides for preparing anti-virus or/and anti-tumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1: Add 8 to 10 times the amount of water to the seeds or whole plant of Sophora serrata, extract twice at 80°C to 100°C for 2 hours to 3 hours each time, filter, combine the filtrate and concentrate to obtain a crude extract concentrate Liquid; add anhydrous ethanol equivalent to 1 to 2 times the volume of the crude extract concentrate, leave it to settle for 24 hours, filter out the precipitate, concentrate and recover the ethanol to obtain the concentrate; concentrate AB-8 type macroporous resin on the concentrate Chromatographic column adsorption, flush the column with deionized water equivalent to 2 to 5 chromatographic column volumes to remove impurities, and then use 50% ethanol as the eluent to elute the column. The amount is equivalent to 2 to 8 chromatographic column volumes, the flow rate is 2 to 5 chromatographic column volumes / hour, collect the ethanol eluate and combine, concentrate at 50°C to 80°C, and recover the ethanol to obtain the extract extra...

Embodiment 2

[0041] Example 2: Add 8 to 10 times the amount of water to the seeds or whole plant of Sophora serrata, extract twice at 80°C to 100°C for 2 hours to 3 hours each time, filter, combine the filtrate and concentrate to obtain a crude extract concentrate Liquid; add anhydrous ethanol equivalent to 1 to 2 times the volume of the crude extract concentrate, leave it to settle for 24 hours, filter out the precipitate, concentrate and recover the ethanol to obtain the concentrate; concentrate AB-8 type macroporous resin on the concentrate Chromatographic column adsorption, flush the column with deionized water equivalent to 2 to 5 chromatographic column volumes to remove impurities, and then use 50% ethanol as the eluent to elute the column. The amount is equivalent to 2 to 8 chromatographic column volumes, the flow rate is 2 to 5 chromatographic column volumes / hour, collect the ethanol eluate and combine, concentrate at 50°C to 80°C, and recover the ethanol to obtain the extract extrac...

Embodiment 3

[0042] Example 3: Add 8 to 10 times the amount of water to the seeds or whole plant of Sophora serrata, extract twice at 80°C to 100°C for 2 hours to 3 hours each time, filter, combine the filtrate and concentrate to obtain a crude extract concentrate Liquid; add anhydrous ethanol equivalent to 1 to 2 times the volume of the crude extract concentrate, leave it to settle for 24 hours, filter out the precipitate, concentrate and recover the ethanol to obtain the concentrate; concentrate AB-8 type macroporous resin on the concentrate Chromatographic column adsorption, flush the column with deionized water equivalent to 2 to 5 chromatographic column volumes to remove impurities, and then use 50% ethanol as the eluent to elute the column. The amount is equivalent to 2 to 8 chromatographic column volumes, the flow rate is 2 to 5 chromatographic column volumes / hour, collect the ethanol eluate and combine, concentrate at 50°C to 80°C, and recover the ethanol to obtain the extract extra...

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Abstract

The invention provides an anti-virus or / and anti-tumor drug and a preparation method thereof and an application of fenugreek biflavone glycosides for preparing anti-virus or / and anti-tumor drugs. The invention provides the application of the chemical component fenugreek biflavone glycosides in fenugreek seeds as drugs for the first time, and uses the fenugreek biflavone glycosides for preparing anti-virus drugs and anti-tumor drugs for the first time. In vivo and in vitro experiment research shows that fenugreek biflavone glycoside tablets or fenugreek biflavone glycoside capsules of the invention have obvious effect on resisting influenza viruses, and the anti-influenza drug effect of the fenugreek biflavone glycoside tablets or fenugreek biflavone glycoside capsules of the invention is superior to the anti-influenza drug effect of the existing Western medicine ribavirin tablets. The anti-HBV effect of the fenugreek biflavone glycoside tablets or fenugreek biflavone glycoside capsules is superior to the anti-HBV effect of kurarinone capsules, and the anti-HIV effect of the fenugreek biflavone glycoside tablets or fenugreek biflavone glycoside capsules is superior to the anti-HIV effect of zidovudine tablets. The fenugreek biflavone glycoside tablets or fenugreek biflavone glycoside capsules have obvious effect on resisting proliferation of liver cancer, gastric cancer, intestinal cancer, lung cancer and cervical cancer cells, and the anti-tumor effect of the fenugreek biflavone glycoside tablets or fenugreek biflavone glycoside capsules is superior to the anti-tumor effect of the existing chemical component preparation hydroxycamptothecine injection.

Description

technical field [0001] The present invention relates to the technical field of the application of chemical components extracted and separated from plants as medicines, and is an antiviral or / and antitumor medicine and its preparation method, and the use of alopecia glycosides in the preparation of antiviral or / and antitumor medicines The present invention proposes for the first time the use of the chemical component alopecia glucoside in Sophora alopecuroides as medicine, and applies alopecia glycoside to the preparation of antiviral drugs and antitumor drugs for the first time. Background technique [0002] The incidence of viral infectious diseases is very high, and the mortality rate is also very high. Its spread not only causes serious social impact and economic losses, but also kills countless creatures like demons anytime and anywhere. Among the many viruses that have been discovered by human beings, the influenza virus can be called the oldest. Due to its high variabi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P31/12A61P35/00A61P31/16A61P31/18A61P31/20C07D407/14
Inventor 黄华王雪赵军王林林杨巧丽姚华史玉柱
Owner XINJIANG INST OF MATERIA MEDICA
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