Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Compositions and methods of use of compounds to increase cancer patient survival time

A technology for patients, chemotherapeutic drugs, applied in the field of new pharmaceutical compositions, to determine the potential growth "aggressiveness" of specific cancers and the response to specific cancer treatments, and to address issues such as increased oxidative metabolism

Active Publication Date: 2013-12-18
BIONUMERIK PHARMA INC
View PDF33 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is also recognized that NSCLC and adenocarcinoma have increased oxidative metabolism and / or increased thioredoxin and / or glutaredoxin concentrations and can further overexpress them in response to chemotherapy, leading to tumor-mediated response to chemotherapy. drug resistance

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compositions and methods of use of compounds to increase cancer patient survival time
  • Compositions and methods of use of compounds to increase cancer patient survival time
  • Compositions and methods of use of compounds to increase cancer patient survival time

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0192] The descriptions and embodiments set forth herein are not intended to be exhaustive nor to limit them to the precise forms of the invention disclosed. They are included to illustrate the principles of the invention and its application and practical use to those skilled in the art.

[0193] definition

[0194] As used herein, the term "general structural formula" means a fixed structural portion of a molecule of a given formula.

[0195] As used herein, the term "nucleophile" means an ion or molecule that donates electron pairs to a nucleus to form a covalent bond; nuclei that accept electrons are called electrophiles. This occurs, for example, in the formation of acids and bases according to the Lewis concept and in the bonding of carbons in organic compounds.

[0196] The term "fragment", "moiety" or "substituent" as used herein is represented by a variable symbol such as R x , X or other symbols in the variable part of the molecule named in the formula. Substitu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
Login to View More

Abstract

The present invention discloses and claims compositions, methods of treatment, and kits which cause an increase in time of survival in cancer patients, wherein the cancer either: (i) overexpresses thioredoxin or glutaredoxin and / or (ii) exhibits evidence of thioredoxin- or glutaredoxin-mediated resistance to one or more chemotherapeutic interventions. The present invention also discloses and claims methods and kits for the administration of said compositions to properly treat cancer patients. Additionally, the present invention discloses and claims methods and kits for quantitatively determining the level of expression of thioredoxin or glutaredoxin in the cancer cells of a cancer patient, methods of using those determined levels in the initial diagnosis and / or planning of subsequent treatment methodologies for said cancer patient, as well as ascertaining the potential growth 'aggressiveness' of the particular cancer and treatment responsiveness of the particular type of cancer. Further, the present invention discloses and claims novel pharmaceutical compositions, methods, and kits used for the treatment of patients with medical conditions and disease where there is the overexpression of thioredoxin and / or glutaredoxin, and wherein this overexpression is associated with deleterious physiological effects in the patients.

Description

[0001] related application [0002] This application is a continuation-in-part of U.S. Patent Application Serial No. US 12 / 075,980, filed March 14, 2008, and entitled "Methods and Compositions for Therapy of Lung Cancer, Adenocarcinoma, and Other Medical Conditions," and claims its Priority, the disclosure of this document is hereby incorporated by reference in its entirety. technical field [0003] The present invention relates to novel pharmaceutical compositions, methods and kits for the treatment of cancer and other medical conditions. More specifically, the present invention relates to novel pharmaceutical compositions, methods and kits for the treatment of lung cancer, adenocarcinoma and other medical diseases. In addition, the present invention relates to compositions, methods of treatment and kits resulting in increased survival time of cancer patients, wherein said cancer: (i) overexpresses thioredoxin or glutaredoxin and / or (ii) exhibits thioredoxin Evidence of res...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/255
CPCA61K31/255A61P35/00A61P35/02
Inventor F·H·豪希尔
Owner BIONUMERIK PHARMA INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com