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Valerian preparation for tranquilizing and allaying excitement and preparation method thereof

A kind of valerian, preparation technology, applied in the field of medicine, can solve problems such as inattention

Inactive Publication Date: 2011-05-18
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently clinically commonly used tranquilizers have side effects such as dizzi

Method used

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  • Valerian preparation for tranquilizing and allaying excitement and preparation method thereof
  • Valerian preparation for tranquilizing and allaying excitement and preparation method thereof
  • Valerian preparation for tranquilizing and allaying excitement and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: valerian oil is directly sprayed in dry granule and prepares tablet (50)

[0029] Mix 1.5g of valerian extract with 2.575g of microcrystalline cellulose and 2.575g of starch, and spray 70% ethanol several times in a small amount to make a soft material suitable for wet and dry. Manually extrude the soft material through a 14-mesh sieve to obtain wet granules, and dry at 40-45°C for 2 hours. 14 mesh sieve for granulation. After dissolving 1g of valerian oil with 1g of absolute ethanol, add it to the part of the fine powder sieved from the dry granules during sizing, and then mix it with other granules. Add 1.125g of disintegrant (crospovidone) and 0.225g of lubricant (magnesium stearate and talc) in small amounts for several times, place in a closed container for 4 hours, so that valerian oil is fully absorbed in the granules, and dry at room temperature . Tablet.

Embodiment 2

[0030] Embodiment 2: Preparation of tablet (50 pieces) after valerian oil is clathrated with β-cyclodextrin

[0031] Mix 4.5g clathrate and 1.5g valerian extract evenly, add 2.575g microcrystalline cellulose and 2.575g starch, mix evenly, spray 70% ethanol several times in a small amount to make a soft material suitable for dry and wet. Manually extrude the soft material through a 14-mesh sieve to obtain wet granules, and dry at 40-45°C for 2 hours. 14 mesh sieve for granulation. Add 1.125g of disintegrant (crospovidone) and 0.225g of lubricant (magnesium stearate and talcum powder) in small amounts for multiple times, mix well, and compress into tablets.

Embodiment 3

[0032] The sedative and tranquilizing effect research of embodiment 3 valerian oil preparations

[0033] (1) Influence on autonomous activity of mice

[0034] Fifty KM mice, half male and half male, were randomly divided into 5 groups: blank control group, positive control group, low, medium and high dose groups of valerian preparation, 10 mice in each group. One day of pre-adaptation, administration on the second day of the experiment, the blank control group: fed with 1% Tween-80 normal saline solution 0.2mL / 10g; the positive control group: fed with Diazepam 1% Tween-80 normal saline suspension ( 1mg / kg) 0.2mL / 10g; sample low, medium and high dose groups were given 0.2mL / 10g by dose. 1 time a day, 9:00-10:00 in the morning, for 7 consecutive days. 55 minutes after the last administration, the mice in each group were placed in the autonomic activity apparatus, and after 5 minutes of adaptation, the number of autonomous activities of the mice within 10 minutes was observed a...

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Abstract

The invention discloses a valerian preparation for tranquilizing and allaying excitement and a preparation method thereof. A valerian extract is used as a main raw material. The method comprises the steps of: mixing valerian oil with the valerian extract in a proportion of 1:15, and preparing a tablet by using a wet granulation process. The stability of the valerian oil can be effectively improved by adopting the process disclosed in the invention, and adverse tastes are covered. Results of experiments and researches for pharmacology indicate that the preparation has the characteristics of high stability, little toxic and side effects, convenience for carrying and simple process, and has a remarkable treatment or improvement function on the insomnia.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a medicinal preparation for calming and calming the nerves and a preparation method thereof. Specifically, it is a pure natural plant medicine prepared from Chinese herbal medicine, and the invention also relates to a preparation method of the medicine preparation. Background technique [0002] Good sleep is the basis for ensuring work efficiency and quality of life, and it is also an important symbol of physical and mental health. Long-term insomnia will lead to diseases such as anxiety and depression, and further aggravate the symptoms of insomnia. According to the survey data released by the World Health Organization (WHO) on February 28, 2004, about 1 / 4 of the population worldwide suffers from insomnia to varying degrees, and 1 / 3 of them is already classified as severe insomnia. The current incidence of insomnia in my country has also reached 20%, and the middle-aged and elderly peopl...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/20A61P25/20
Inventor 崔京浩吴丹曹青日
Owner SUZHOU UNIV
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