Porcine interferon-gamma composite medicament and application thereof

Abstract

The invention relates to a porcine interferon-gamma composite medicament and application thereof, belonging to the technical field of rear livestock medicaments. Per liter of porcine interferon-gamma composite medicament injection is prepared from the following raw materials: 400-500ml of porcine interferon-gamma, 100-180g of astragalus mongholicus extract, 100-180g of golden cypress extract, 100-180g of coptis extract, 20-30g of codonopsis extract, 40-80g of licorice extract and 2-8g of bursin. The porcine interferon-gamma composite medicament injection has a good effect in the processes of treating and preventing piglet infectious gastroenteritis and pig epidemic diarrhea, and the effective prevention rate is above 85%.

Description

technical field

[0001] The invention relates to a porcine interferon gamma combination drug and its application, belonging to the technical field of animal husbandry drugs. Background technique

[0002] Interferon γ was discovered by Wheelock in 1956. It is produced by activated T cells and NK cells and has strong antiviral and immune regulatory functions. Its biological activities mainly include:

[0003] 1. Immunomodulatory effect: Interferon gamma can increase the expression of IgG Fc receptors, which is conducive to the phagocytosis of antigens by macrophages, the killing of target cells by NK cells and the activation of T lymphocytes and B lymphocytes, thereby enhancing the body immune response.

[0004] 2. Antiviral effect: Interferon gamma exerts its effect through some proteins encoded by cell genes. It first binds to cell surface receptors, enters cells, induces the synthesis of antiviral proteins, and thus exerts antiviral effects.

[0005] In 1998, Vandenbroeck...

Examples

Embodiment 1

[0028] A kind of porcine interferon gamma combination drug injection, every liter of porcine interferon gamma combination drug injection is made of the following raw materials:

[0029] Porcine interferon gamma 400ml, Astragalus extract 100g, Cortex Phellodendri extract 100g, Coptis chinensis extract 100g, Codonopsis pilosula extract 20g, licorice extract 40g, bursin peptide 2g;

[0030] The above-mentioned porcine interferon gamma combination drug injection is prepared as follows:

[0031] Weigh the above-mentioned raw materials, stir and mix in an ice bath for 15 minutes, add water for injection to 1000ml to make a liquid suspension, filter and sterilize through a 0.22 μm cellulose membrane, and obtain the porcine interferon gamma combination drug injection, and then pack until sterilized. In the vials and dishes of bacteria, the quality inspection is put into the warehouse, and the finished product is stored at 4°C.

Embodiment 2

[0033] The porcine interferon gamma combination drug injection as described in Example 1, the difference is that every liter of porcine interferon gamma combination drug injection is made of the following raw materials:

[0034] Porcine interferon gamma 430ml, Astragalus extract 120g, Cortex Phellodendri extract 120g, Coptis chinensis extract 120g, Codonopsis pilosula extract 22g, licorice extract 50g, bursin peptide 3.5g.

Embodiment 3

[0036] The porcine interferon gamma combination drug injection as described in Example 1, the difference is that every liter of porcine interferon gamma combination drug injection is made of the following raw materials:

[0037] Porcine interferon gamma 460ml, Astragalus extract 150g, Cortex Phellodendron extract 150g, Coptis chinensis extract 150g, Codonopsis pilosula extract 25g, licorice extract 60g, bursin peptide 5g.

technical field

[0001] The invention relates to a porcine interferon gamma combination drug and its application, belonging to the technical field of animal husbandry drugs. Background technique

[0002] Interferon γ was discovered by Wheelock in 1956. It is produced by activated T cells and NK cells and has strong antiviral and immune regulatory functions. Its biological activities mainly include:

[0003] 1. Immunomodulatory effect: Interferon gamma can increase the expression of IgG Fc receptors, which is conducive to the phagocytosis of antigens by macrophages, the killing of target cells by NK cells and the activation of T lymphocytes and B lymphocytes, thereby enhancing the body immune response.

[0004] 2. Antiviral effect: Interferon gamma exerts its effect through some proteins encoded by cell genes. It first binds to cell surface receptors, enters cells, induces the synthesis of antiviral proteins, and thus exerts antiviral effects.

[0005] In 1998, Vandenbroeck...

Examples

Embodiment 1

[0028] A kind of porcine interferon gamma combination drug injection, every liter of porcine interferon gamma combination drug injection is made of the following raw materials:

[0029] Porcine interferon gamma 400ml, Astragalus extract 100g, Cortex Phellodendri extract 100g, Coptis chinensis extract 100g, Codonopsis pilosula extract 20g, licorice extract 40g, bursin peptide 2g;

[0030] The above-mentioned porcine interferon gamma combination drug injection is prepared as follows:

[0031] Weigh the above-mentioned raw materials, stir and mix in an ice bath for 15 minutes, add water for injection to 1000ml to make a liquid suspension, filter and sterilize through a 0.22 μm cellulose membrane, and obtain the porcine interferon gamma combination drug injection, and then pack until sterilized. In the vials and dishes of bacteria, the quality inspection is put into the warehouse, and the finished product is stored at 4°C.

Embodiment 2

[0033] The porcine interferon gamma combination drug injection as described in Example 1, the difference is that every liter of porcine interferon gamma combination drug injection is made of the following raw materials:

[0034] Porcine interferon gamma 430ml, Astragalus extract 120g, Cortex Phellodendri extract 120g, Coptis chinensis extract 120g, Codonopsis pilosula extract 22g, licorice extract 50g, bursin peptide 3.5g.

Embodiment 3

[0036] The porcine interferon gamma combination drug injection as described in Example 1, the difference is that every liter of porcine interferon gamma combination drug injection is made of the following raw materials:

[0037] Porcine interferon gamma 460ml, Astragalus extract 150g, Cortex Phellodendron extract 150g, Coptis chinensis extract 150g, Codonopsis pilosula extract 25g, licorice extract 60g, bursin peptide 5g.

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