Anti-tuberculosis gel preparation

A gel preparation and anti-tuberculosis technology, which is applied in the field of ultrasonic therapy, can solve the problems such as the availability of ultrasonic coupling preparations without tuberculosis drugs, and achieve the effect of good ultrasonic coupling performance and easy quantification.

Active Publication Date: 2014-05-14
北京诺亚同舟医疗技术有限公司
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AI Technical Summary

Problems solved by technology

So far, there is no ultrasound-coupled formulation for ultrasound drug infiltration carrying tuberculosis drugs available

Method used

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  • Anti-tuberculosis gel preparation

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Experimental program
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Effect test

Embodiment 1

[0019] Prescription: Sodium Hyaluronate 1.5

[0020] Azone 0.5

[0021] Glycerin 10

[0022] Propylene Glycol 10

[0023] Isoniazid 1

[0024] Rifamycin 3

[0025] Distilled water 74

[0026] Soak sodium hyaluronate in distilled water for a certain period of time to make it swell, and dissolve it in a water bath, add azone, propylene glycol, glycerin, and exchange resin and stir evenly; finally add the drug ingredients and stir evenly.

Embodiment 2

[0028] Clinical observation of tuberculosis treated with ultrasonic conductivity meter and local anti-tuberculosis drug preparations: Purpose To explore the efficacy and safety of local anti-tuberculosis gel preparations in the treatment of tuberculosis by investigating the curative effect of anti-tuberculosis drug gel preparations on ultrasound conductance transmission. method 61 cases of tuberculosis patients were selected by random double-blind method and divided into two groups: ultrasonic conductance drug and drug hot compress. They were treated with ultrasonic conductance transmission anti-tuberculosis gel preparation and oral drugs respectively, and multiple observation indexes of patients before and after treatment were compared. result Ultrasound conductance transmission of anti-tuberculosis gel preparations is more effective than conventional oral drugs in the treatment of tuberculosis (see Table 1). in conclusion Ultrasonography transmissive anti-tuberculos...

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Abstract

The present invention provides an anti-tuberculosis gel preparation, which belongs to the technical field of ultrasonic therapy. The anti-tuberculosis gel preparation comprises, on the basis of dosage percentage, 0.5 to 8% of hydrophilic polymer materials, 0.5 to 15% of penetration enhancers, 2 to 10% of humectants, 0.5 to 3% of isoniazid, 2 to 5% of rifamycin and water. The preparation method for the gel preparation comprises the following steps: 1, preparing the components of gel preparation in proportion; 2, immersing the hydrophilic polymer materials in water to dissolve the materials; 3, adding the penetration enhancers and humectants into the obtained solution and carrying out stirring until the penetration enhancers and humectants dissolve; 4, adding isoniazid and rifamycin into the solution and carrying out uniform mixing under stirring. When used for ultrasonic medicine phoresis therapy, the gel preparation can guarantee that carried drug components smoothly penetrate into bodies to exert pharmacological effects and treat tuberculosis, besides exerting an effect of ultrasonic coupling.

Description

technical field [0001] The invention belongs to the technical field of ultrasonic therapy, and in particular relates to an anti-tuberculosis gel preparation and a preparation method. Background technique [0002] Tuberculosis is the most common type 2 infectious disease in humans, and isoniazid and rifampicin are commonly used drugs for the treatment of such diseases. At present, anti-tuberculosis drugs are all oral and injection preparations, such as the application number 200810146570.6 Invention of traditional Chinese medicine preparation for treating rheumatism and bone disease, 200410066177.8 A new preparation of anti-rheumatic traditional Chinese medicine and its preparation process invention, 200710007869.9 Muscle and bone rheumatism traditional Chinese medicine plaster and 200410061292.6 Bone injury Invention patents such as traditional Chinese medicine external application powder. [0003] Most of the existing drugs for treating tuberculosis contain toxic ingredien...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61K49/22A61K9/00A61K47/38A61K47/36A61K47/32A61P31/06A61K31/4409
Inventor 梁建琴翁春晓
Owner 北京诺亚同舟医疗技术有限公司
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