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MIF secretion inhibitor

A technology of secretion inhibitor and migration inhibition, applied in the field of macrophage migration inhibitory factor (MIF) secretion inhibitor, can solve the problem that the secretion inhibition effect is unknown and other problems

Inactive Publication Date: 2012-12-12
FUAN KERU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Calendula has traditionally been used as a laxative, diuretic, diaphoretic, and menstruation agent, but the secretion-inhibiting effect of MIF from calendula extract is not yet known

Method used

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Embodiment

[0045] Hereinafter, the present invention will be described in detail.

[0046] [Effect of Calendula flower extract in UVB-induced MIF secretion inhibition test using keratinocytes]

[0047] MIF is known to be highly expressed in keratinocytes, which are one of the constituent cells of the skin. Furthermore, it is known that the secretion of MIF is promoted by irradiating keratinocytes with UVB (J Invest Dermatol, 112, 2, 210-15, 1999). Therefore, it was analyzed whether or not the marigold extract suppresses the secretion of MIF when keratinocytes are irradiated with UVB. The calendula extract used in this test was the calendula extract (sample A) manufactured by Koei Kogyo Co., Ltd., and the marigold extract BG-J (sample B) manufactured by Maruzen Pharmaceutical Co., Ltd. Although the test method is described in detail below, the test method is slightly different for different samples, and the optimum conditions for cell growth and development can be set according to the d...

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Abstract

The present invention provides a MIF secretion inhibitor, and is a secretion inhibitor for macrophage migration inhibition factor containing calendula or extracts thereof.

Description

technical field [0001] The present invention relates to an inhibitor of macrophage migration inhibitory factor (MIF) secretion and an agent for improving inflammatory diseases. Background technique [0002] Macrophage migration inhibitory factor (hereinafter referred to as MIF) is one of the mediators of inflammation and immunity. It is a humoral factor that controls the movement of macrophages, gathers macrophages at the site of inflammation, and improves phagocytosis. MIF is involved in chronic rheumatoid arthritis (Non-Patent Document 1: Expert Opin Ther Targets, 7, 2, 153-164, 2003), nephritis (Non-Patent Document 2: Expert Opin Ther Atopic dermatitis (Non-Patent Document 3: Biochem Biophys Res Commun, 240, 11, 173-8, 1997), psoriasis (Non-Patent Document 4: B J Dermatol, 141, 1061-66, 1999), ulcerative colitis, sepsis, contact Dermatitis (Non-Patent Document 5: Eur J Immunol, 33, 1478-87, 2003), inflammation caused by ultraviolet rays (Non-Patent Document 6: J Invest D...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61P17/00
CPCA61P29/00A61K36/28
Inventor 榎本有希子
Owner FUAN KERU
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