Microfluid cell capturing chip and manufacture method thereof

A technology of microfluidics and a manufacturing method, applied in the field of cell capture tools and their preparation, can solve the problems of invasive sampling and the like, and achieve the effects of rapid and efficient separation, simple structure, and easy manufacture.

Active Publication Date: 2014-06-18
WUHAN YZY MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] The technical problem to be solved by the present invention is to propose a microfluidic cell capture chip capable of separating and enriching rare cells from human body fluid samples, so as to solve the problems of invasive sampling in the prior art

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  • Microfluid cell capturing chip and manufacture method thereof
  • Microfluid cell capturing chip and manufacture method thereof
  • Microfluid cell capturing chip and manufacture method thereof

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Embodiment Construction

[0031] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0032] like Figure 1 to Figure 3 As shown, the embodiment of the present invention provides a microfluidic cell capture chip 100 for capturing microfluidic cells 200 . The microfluidic cell capture chip 100 includes an upper transparent glass piece 10 and a lower transparent glass piece 20, a channel 30 is formed between the upper transparent glass piece 10 and the lower transparent glass piece 20, and the channel has an inlet 32 ​​and an outlet 34 The height of the channel 30 from the inlet 32 ​​to the outlet 34 gradually transitions from high to low and is wedge-shaped or a part of the channel ...

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Abstract

A microfluidic chip (100) for capturing cells (200) and preparing method thereof. The chip (100) comprises an upper rigid material (10) and a lower rigid material (20), a channel (30) provided between the upper rigid material (10) and the lower rigid material (20). The channel has an inlet (32) and an outlet (34). At least one of the upper rigid material (10) and the lower rigid material (20) is made of transparent material. The channel (30) has a height decreasing gradually from the inlet (32) to the outlet (34), thus a wedge shape is formed, or a portion of the channel has the wedge shape. The lowest portion of the channel (30) has a dimension approximating to or less than that of at least one of target cells. The chip (100) could quickly, effectively separate and enrich cells with various sizes and specific molecular expressions.

Description

technical field [0001] The present invention relates to a cell capture tool and its preparation method, in particular to a microfluidic cell capture chip for separating, enriching and identifying circulating tumor cells and its preparation method. The microfluidic cell capture chip can be used for tumor diagnosis and adjuvant therapy , and a favorable tool for biochemical analysis research. Background technique [0002] Currently, tumor diagnosis is usually made on the basis of a large number of pathological conditions. Such methods, such as biopsies or digital examinations for rectal cancer, are usually analyzed invasively, which is somewhat invasive and detrimental to the patient. [0003] In addition, biomolecular markers in peripheral blood are also used for inspection, such as the detection of serological parameters (PSA dose). Due to their unsatisfactory sensitivity and specificity, it is difficult to achieve good results in cancer diagnosis and treatment. [0004] F...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M1/00
CPCB01L3/00G01N2015/0288G01N33/48G01N15/02C12M1/00C12Q1/00C12M47/04B01L3/502753B01L2300/0654B01L2300/0816B01L2400/086Y10T29/49888B01L3/502707B01L2300/12B01L2300/16G01N33/5044
Inventor 刘侃汪胜祥张南刚周鹏飞
Owner WUHAN YZY MEDICAL SCI & TECH
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