Pharmaceutical composition for inhibiting cancer stem cell growth or cancer cell metastasis by using wogonin, and application thereof

A technology of wogonin and cancer stem cells is applied in the field of pharmaceutical compositions containing wogonin compounds to inhibit the growth of cancer stem cells or the metastasis of cancer cells, and the field of medicines for inhibiting the growth of cancer stem cells or the metastasis of cancer cells, which can solve the strong side effects of patients. And other issues

Inactive Publication Date: 2013-03-20
谢秀梅 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, surgery, radiation therapy, chemotherapy, hormone therapy, biological agent therapy, etc. currently used in Western medicine often have strong side effects on the patient's body, so if they can be used mildly, and can inhibit the growth of cancer stem cells or cancer Cell transfer therapy, cancer treatment, will be a great boon for patients

Method used

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  • Pharmaceutical composition for inhibiting cancer stem cell growth or cancer cell metastasis by using wogonin, and application thereof
  • Pharmaceutical composition for inhibiting cancer stem cell growth or cancer cell metastasis by using wogonin, and application thereof
  • Pharmaceutical composition for inhibiting cancer stem cell growth or cancer cell metastasis by using wogonin, and application thereof

Examples

Experimental program
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preparation example Construction

[0063] Preparation of Scutellaria baicalensis extract

[0064] Take 11.25 grams of Scutellaria baicalensis (Coptis chinensis), add 1.2 liters of water, boil and extract for 1 hour, and about 450 ml of the extracted product can be obtained, which is divided into several parts and stored at 4°C. In addition to the above-mentioned direct storage of the aqueous extract at 4°C, freeze-drying can also be used to store the extract.

[0065] Before performing subsequent experiments, the extracted products stored at 4°C were first filtered with a 0.22 μm filter membrane.

[0066] Preparation of wogonin solution

[0067] Using dimethyl sulfoxide (DMSO) as a solvent, wogonin hydrate (wogonin hydrate, purchased from Wako) was dissolved to prepare wogonin solutions with different concentrations.

[0068] cell culture

[0069] Non-small cell lung cancer (NSCLC) cell lines A549, NCI-H460 and NCI-H520 and normal lung cells were purchased from Taiwan Bioresource Collection and Research Center...

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Abstract

The invention relates to a pharmaceutical composition for inhibiting cancer stem cell growth or cancer cell metastasis by using wogonin, and an application thereof. The pharmaceutical composition comprises a wogonin compound and a pharmaceutically acceptable vector. The application of the pharmaceutical composition is to prepare medicaments for inhibiting the cancer stem cell growth or the cancer cell metastasis by using the wogonin compound.

Description

technical field [0001] The present invention relates to a pharmaceutical composition for inhibiting the growth of cancer stem cells or cancer cell metastasis (growth of cancer stem cells) and its application, especially a kind of wogonin compounds (wogonin compounds) to inhibit the growth of cancer stem cells or cancer cell A medicinal composition for metastasis and the use of wogonin compound to manufacture a medicament for inhibiting the growth of cancer stem cells or metastasis of cancer cells. Background technique [0002] Cancer has ranked first among the top ten causes of death for 27 consecutive years. When cells become abnormal and continue to divide on their own, more abnormal cells are formed, which can lead to cancer. [0003] In general tumor cells, there are some cancer cells with stem cell characteristics latent. Although the number of such cancer cells is small, they are similar to stem cells and can continuously divide and differentiate cancer cells, so they...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K36/539A61P35/00A61P35/04
Inventor 谢秀梅李政育沈志谦王天骏
Owner 谢秀梅
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