Caspase-1 inhibitor targeting liver and application thereof

A pre-s1, inhibitor technology, applied in biomedicine, enzyme inhibitor and in the field of medicine, can solve problems such as difficulty in terminating chronic hepatitis B, and achieve the effect of reducing production, reducing internal environment disturbance and immune deficiency
CN102977215BActive Publication Date: 2014-03-19ARMY MEDICAL UNIV
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
ARMY MEDICAL UNIV
Publication Date
2014-03-19

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Abstract

The invention discloses a caspase-1 inhibitor targeting liver. The caspase-1 inhibitor is formed by connection of human hepatitis B virus Pre-S1 peptide and caspase-1 inhibitor through a flexible connector, wherein the Pre-S1 peptide consists of amino acids from first to fiftieth of the Pre-S1 protein; and the caspase-1 inhibitor is formed by connection of trimolecular polymer of YVAD tetrapeptide and trimolecular polymer of VAD tripeptide. According to the inhibitor, the caspase-1 inhibitor is specifically targeted to a liver cell by utilizing the carrier Pre-S1 peptide which specifically targets liver, so that intrahepatic persistent chronic inflammation caused by endogenous danger signals released by injured liver cells can be blocked by terminating caspase-1 activation in the liver cell, sequential spinal cord injury of the liver cell can be blocked, body adverse response which is possibly caused by spread inhibition of caspase-1 can be reduced, and the liver cell can be specifically and effectively protected. The caspase-1 inhibitor can be used for preparing a medicament for treating intrahepatic chronic inflammation caused by endogenous danger signals released by injured liver cells.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and relates to an enzyme inhibitor and its application in the field of medicine. Background technique

[0002] Chronic liver injury mainly caused by chronic hepatitis is a major health problem in my country, and it is also one of the main causes of human death announced by the World Health Organization. Once chronic liver inflammation starts, it is difficult to stop, and further causes liver cirrhosis, liver failure, and liver cancer, which is called the "trilogy of chronic liver disease"; trauma".

[0003] Previous studies have believed that the activity of the virus in the liver is an important reason for the persistence of intrahepatic inflammation, so antiviral therapy is currently the most commonly used method for the treatment of chronic hepatitis B. However, studies have found that even if the virus replication is effectively inhibited, it is difficult to stop the malignant course of chronic h...

Claims

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