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Application of Acanthopanax obovatus Hoo in peptic ulcer resistance and medicine prepared from Acanthopanax obovatus Hoo

An anti-digestion technology of Acanthopanax ovalifolia, applied in the direction of medical preparations containing active ingredients, applications, digestive system, etc., can solve the problems of not being suitable for long-term medication, treating the symptoms but not the root cause, and single effect, etc., to achieve the material basis of action And the effect of clear mechanism of action, quick effect and mild medicinal properties

Active Publication Date: 2014-12-03
陕西中药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many kinds of drugs for the treatment of peptic ulcer and chronic gastritis, but most of them have a single effect and need to be combined with drugs, and they treat the symptoms but not the root cause, and have relatively large side effects, so they are not suitable for long-term medication

Method used

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  • Application of Acanthopanax obovatus Hoo in peptic ulcer resistance and medicine prepared from Acanthopanax obovatus Hoo
  • Application of Acanthopanax obovatus Hoo in peptic ulcer resistance and medicine prepared from Acanthopanax obovatus Hoo
  • Application of Acanthopanax obovatus Hoo in peptic ulcer resistance and medicine prepared from Acanthopanax obovatus Hoo

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Preparation of Acanthopanax Obovata Water Extract:

[0041] Take the medicinal material of Acanthopanax obtusifolia, break it, add water to decoc three times, add 10 times the quality of the medicinal material for the first time and boil it for 1 hour, add 8 times the amount of water for the second time and boil for 1 hour, and add 8 times the amount of water for the third time Decoction for 0.5 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to a clear paste with a relative density of 1.30 to 1.35 (measured at 55°C), dry under vacuum under reduced pressure, and pulverize into a fine powder. Dry paste powder.

Embodiment 2

[0042] Example 2 Preparation of Acanthopanax Obovatum Alcohol Extract

[0043] Take the Acanthopanax obovii medicinal materials, break them, add 10 times the mass of 60% ethanol, heat and reflux for extraction, collect the extract for 1 hour each time, let it stand, filter, recover the ethanol under reduced pressure and concentrate to a relative density of 1.12 (50 ~60℃) cleansing ointment, spray-dried to obtain the ethanol extract of Acanthopanax obovata.

Embodiment 3

[0044] Example 3 Preparation of Acanthopanax Obovata water and alcohol precipitation extract

[0045] Take the medicinal materials of Acanthopanax obtusifolia, break it, add water to decoct twice, the first time add 10 times the amount of water to decoc for 1 hour, the second time add 8 times the amount of water to decoc for 0.5 hours, combine the decoction liquid, filter, Concentrate under reduced pressure to a relative density of 1.25~1.30 (55℃), let cool, add ethanol to make the alcohol content reach 65%, let stand for 24 hours, take the supernatant liquid under reduced pressure to recover ethanol and concentrate to a relative density of 1.30~1.35 (Measured at 55°C), dried under reduced pressure in a vacuum and crushed to obtain a dry paste powder of the water-extracted and alcohol-precipitated extract of Acanthopanax Obovatus.

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Abstract

The invention discloses application of Acanthopanax obovatus Hoo in peptic ulcer resistance and a medicine prepared from the Acanthopanax obovatus Hoo, particularly peptic ulcer resistant effect of an Acanthopanax obovatus Hoo extractive. After the extractive is obtained by taking the Acanthopanax obovatus Hoo as the raw material, the result shows that the extractive is capable of effectively protecting and preventing gastric ulcer and duodenal ulcer, repairing gastrointestinal mucosa, promoting Gastrointestinal mucosa ulcer healing and improving gastrointestinal functions; and the Acanthopanax obovatus Hoo extractive has pharmacological actions of resisting stress ulcer, hydrochloric ulcer, indometacin-ethanol ulcer and pylorus ligation ulcer in a dose dependent manner, has obvious abirritation, has better therapeutic action on digestive diseases such as gastric ulcer and the like, and is a safe health-care and curative medicine applied to digestive systems of crowds suffering from gastric ulcer, duodenal ulcer, chronic gastritis, disorders of digestion and the like.

Description

Technical field [0001] The invention belongs to the technical field of anti-peptic ulcer drugs, and relates to the application of the anti-peptic ulcer of Acanthopanax Obovatus and the prepared drugs. Background technique [0002] Peptic ulcer refers to the tissue damage of the gastrointestinal mucosa that exceeds the mucosal muscle layer caused by the digestion of the gastric digestive juice itself. It can occur in any part of the digestive tract. Among them, the stomach and duodenum are the most common, namely gastric ulcer and ten Diodenal ulcer. The disease is a common disease, frequently-occurring, with a total incidence of about 10% to 12% of the population. Due to emotional stress, various psychological factors, bad eating habits and drug stimulation can induce the appearance of ulcers. Mainly manifested as regular upper abdomen pain and discomfort, acid reflux, nausea and vomiting, loss of appetite, weight loss and other symptoms. If improperly treated or not in time, u...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/254A23L1/29A61P1/04A23L33/00
Inventor 朱爱华同卓斌周新民
Owner 陕西中药研究所
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