Tumor targeted delivery of immunomodulators by nanoplymers

A technology of nanopolymers and immunomodulators, applied in antineoplastic drugs, drug combinations, capsule delivery, etc.

Inactive Publication Date: 2013-03-27
BOARD OF RGT THE UNIV OF TEXAS SYST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, systemic injection of CpG leads to the activation of pDC cells in major immune organs and depletes this important type of antitumor cell pool outside the tumor

Method used

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  • Tumor targeted delivery of immunomodulators by nanoplymers
  • Tumor targeted delivery of immunomodulators by nanoplymers
  • Tumor targeted delivery of immunomodulators by nanoplymers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0220] Prophetic Example I, Assessment of Innate and Adaptive Immunity Induced by CpG and PG-Based Nanoconstructs Following Intratumoral Injection.

[0221] In vivo uptake of pDCs. 10 mice / group x 12 groups (except saline) x 3 time points = 360 mice

[0222] GFP transgenic mice. 10 mice / group x 12 groups = 120 transgenic mice

[0223] table 3

[0224] For Prophetic Example II, total: 300 C57BL / 6 mice, 140 transgenic mice

[0225]

[0226] Prophetic Example II, Evaluation of In Vitro and In Vivo Immunostimulatory Activity of Targeted CpG and Tyrosinase-Activatable CpG Nanoconstructs

[0227] Uptake of pDC: 10 mice / group x 7 groups (excluding tyrosinase-knockout tumors) x 2 injection routes = 140 mice

[0228] GFP transgenic mice: 10 mice / group x 7 groups x 2 injection routes = 140 transgenic mice

[0229] Prophetic Example II, Antitumor Activity: 10 mice / group x 16 groups = 160 mice .

[0230] Table 3a

[0231] For Prophetic Example III

[0232] Nano-CpG (...

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Abstract

Nanoconstructs having three components: (1) biodegradable nanopolymers and nanoparticles, (2) immunodrugs such as CpG, and a (3) tumor binding device, which are actively targeted to tumor cells such as melanoma cells through receptor-mediated uptake and methods of using the same are described. Antitumor immunity is further enhanced by combination of PG-CpG nanoconstructs with agonists of positive costimulatory signals and inhibitors of negative immune regulatory signals.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Patent Provisional Application Serial No. 61 / 301,252, filed February 4, 2009. This application is hereby incorporated by reference in its entirety. [0003] Statement Regarding Federal Funding for Research or Development [0004] none. [0005] Names of parties in the joint research agreement [0006] none. [0007] Reference Sequence Listing [0008] none. field of invention [0009] Nanoconstructs comprising biodegradable polymers conjugated to tumor-binding ligands and antibodies that can target tumors and enhance residency at tumor sites are described. Anti-tumor immunity can be further enhanced by combining nanoconstructs with agonists of positive co-stimulatory signals and inhibitors of negative immunoregulatory signals. Background of the invention [0010] Melanoma is the deadliest of the skin cancers because of its propensity to spread widely throughout the body. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K47/30A61K39/395A61K9/127A61K9/48A61P35/00
CPCA61K47/48238A61K47/48315A61K47/4833A61K47/62A61K47/645A61K47/646A61P35/00
Inventor 周大鹏李春P.吴
Owner BOARD OF RGT THE UNIV OF TEXAS SYST
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