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Preparation method of transparent bactericidal medical ultrasonic coupling agent

An ultrasonic coupling agent and bactericidal technology, applied in the direction of echo/ultrasonic imaging agents, etc., can solve problems such as turbidity, affecting product quality and use effect, and incompatibility of material components

Active Publication Date: 2014-08-27
山西康灵医疗器械有限公司
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Problems solved by technology

However, in the process of product transformation and upgrading, due to the addition of fungicides, the original material components cannot be well dissolved, resulting in agglomeration and turbidity, which affects product quality and use effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0005] Material composition and ratio: Carbomer 940: 0.5%, glycerin: 5%, propylene glycol: 5%, triethanolamine: 0.5%, trimethyl blue: 0.01%, triclosan (fungicide): 0.03%, Poloxamer407 (solubilizer): 0.3%, deionized water: 88.66.%

[0006] The preparation method comprises the following steps:

[0007] 1. Carbomer swells in a mixed solvent of glycerin and 20% deionized water, and the temperature is controlled between 36-40c°;

[0008] 2. Add trimethyl blue to the remaining 80% deionized water;

[0009] 3. Add triethanolamine and solubilizer to (2);

[0010] 4. Add the carbomer in step 1 by dripping, and then adjust the pH value to 6.5-7;

[0011] 5. Stir slowly, stand in vacuum, and stir at 30-40 revolutions per minute;

[0012] 6. Dissolve Dp-300 (triclosan) in propylene glycol and add to (1);

[0013] 7. Stir slowly under vacuum for 4 hours;

[0014] 8. Obtain a transparent and bubble-free gel;

[0015] 9. Filling.

[0016] The water-based polymer gel type medical ster...

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Abstract

The invention discloses a preparation method of a transparent bactericidal medical ultrasonic coupling agent, solving the technical problems of product agglomeration and turbidness by adding a certain proportion of solubilizer, adjusting the material mixing sequence and strictly controlling the temperatures and stirring speeds of the materials. The preparation method has the beneficial effects that the water-based polymer gel type medical bactericidal ultrasonic coupling agent has a transparent, exquisite and smooth medium, has good biocompatibility and does not cause cytotoxicity, sensitization or irritation to skins; and the material components are more reasonably proportioned and blended, the product is safer and more reliable and the ultrasonic images are clearer and more stable.

Description

technical field [0001] The invention relates to a medical coupling agent, in particular to a preparation method of a transparent sterilization type medical ultrasonic coupling agent. Background technique [0002] Medical ultrasonic coupling agent is used to fill or apply between the skin-mucosa and the radiation surface of the probe (or treatment head) in ultrasonic diagnosis and treatment operations, and is used as an intermediary medium for transmitting sound waves. contact gel. Ultrasonic coupling agent plays a role in determining the quality and even success in ultrasonic diagnosis and treatment operations. In clinical applications, it not only acts as a sound-transmitting medium, but also acts as a lubricant. Not just its acoustic properties, but also safety and effectiveness goals. Among them, the effectiveness mainly focuses on the sound transmission effect, and the safety mainly focuses on the impact on human tissues and the prevention of cross-infection. With the...

Claims

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Application Information

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IPC IPC(8): A61K49/22
Inventor 吴震东弓海清郝彩萍
Owner 山西康灵医疗器械有限公司
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