Method of producing pleurodesis

A pleurodesis and pleurodesis technology, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, catheters, etc., can solve the problems that are no longer widely used

Inactive Publication Date: 2013-05-01
CAREFUSION 2200 INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has not been widely used since the late 1980s due to the severe pain, fever, and relatively large amount of exudate associated with injecting silver nitrate into the pleural cavity

Method used

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Examples

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Embodiment Construction

[0025]The present invention provides a method of producing pleurodesis in a mammalian individual comprising administering to the individual in need thereof a total dose of from about 5 mg to about 500 mg, preferably from 10 mg to about 450 mg, and more preferably from about 10 mg to about 300 mg, within an administration period. milligrams of silver or silver salts. Total dose refers to the total amount of silver or silver salt administered during the administration period. The administration period refers to the period during which the silver or silver salt is administered to the individual.

[0026] The present invention also provides a method of producing pleurodesis in a mammalian individual comprising administering to the individual in need thereof an average daily dose of about 0.005 mg / kg / day to about 2 mg / kg / day, preferably about 0.01 mg / kg / day, for an administration period. kg / day to about 1 mg / kg / day, more preferably about 0.05 mg / kg / day to about 0.7 mg / kg / day of si...

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Abstract

The present invention provides methods of producing pleurodesis in a mammalian subject, comprising administration of a low dosage of a sclerosing agent such as silver or a salt of silver.

Description

field of invention [0001] The present invention provides a method of producing pleurodesis in a mammalian subject comprising administering a low dose of a sclerosing agent, such as silver or a silver salt. Background of the invention [0002] The pleural cavity and pleura play an important role in helping the lungs function optimally during breathing. Disorders affecting the pleural cavity and pleura include pleural effusions and pneumothorax. Pleural effusion involves the accumulation of fluid around the lungs. Pleural effusions can be associated with diseases such as cancer, tuberculosis, congestive heart failure, pneumonia, pulmonary embolism, viral diseases, cirrhosis, coronary artery bypass surgery, gastrointestinal disease, tuberculosis, and mesothelioma. Pneumothorax occurs when air or gas is present in the pleural space. [0003] Patients with pleural disease, such as symptomatic pleural effusions or pneumothorax, are usually treated with thoracentesis to remove f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61M25/01A61L31/00A61P11/00
CPCA61M25/0045A61M27/00A61M25/00A61M1/00A61K33/38A61M1/008A61P11/00A61P17/02A61L31/00A61M25/01
Inventor 安东尼·路颇格里芬·斯特罗尔
Owner CAREFUSION 2200 INC
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